Towards a wireless micropackaged implant with hermeticity monitoring

The development of reliable hermetic chip-scale micropackaging is one of the major challenges in the miniaturization of implantable medical devices. Protecting the patient from the implanted foreign body and the implant itself from the biological environment is crucial. This paper presents an implantable micropackaging concept to protect a microelectronic system-on-chip. A hermetic chamber is formed by bonding the active CMOS chip to a silicon cover using a gold-tin eutectic sealant. The cover’s fabrication method and the die’s post-processing steps are presented. A humidity sensor inside the chamber monitors the humidity to assess permeability. To power the sensor and read its data, interconnections in the CMOS chip have been designed; these metal tracks pass underneath the cover and thus create a connection between the inside and the outside of the cavity. As an alternative to these connections, an on-chip wireless power management and data communication system is presented with simulated results.

[1]  T. Constandinou,et al.  Hermetic chip-scale packaging using Au:Sn eutectic bonding for implantable devices , 2021, Journal of Micromechanics and Microengineering.

[2]  A. Davoodi,et al.  Uniform nucleation of zincate layer through the optimized etching process to prevent failure in electroless plating on 2024 aluminum alloy , 2021, Engineering Failure Analysis.

[3]  T. Constandinou,et al.  Autonomous Wireless System for Robust and Efficient Inductive Power Transmission to Multi-Node Implants , 2021, bioRxiv.

[4]  J. Burgess Electroplating onto aluminium and its alloys , 2019, Transactions of the IMF.

[5]  Gert Cauwenberghs,et al.  A 3 mm × 3 mm Fully Integrated Wireless Power Receiver and Neural Interface System-on-Chip , 2019, IEEE Transactions on Biomedical Circuits and Systems.

[6]  Timothy G. Constandinou,et al.  EM-Lens Enhanced Power Transfer and Multi-Node Data Transmission for Implantable Medical Devices , 2019, 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[7]  L. Lam,et al.  Scalp‐to‐cortex distance of left primary motor cortex and its computational head model: Implications for personalized neuromodulation , 2019, CNS neuroscience & therapeutics.

[8]  Timothy G. Constandinou,et al.  Towards a Distributed, Chronically-Implantable Neural Interface , 2019, 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER).

[9]  Siyuan Yu,et al.  Wireless Power and Data Link for Ensembles of Sub-mm scale Implantable Sensors near 1GHz , 2018, 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[10]  Timothy G. Constandinou,et al.  Robust Wireless Power Transfer to Multiple mm-Scale Freely-Positioned Neural Implants , 2018, 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS).

[11]  Timothy G. Constandinou,et al.  Hermetic packaging for implantable microsystems: Effectiveness of sequentially electroplated AuSn alloy , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[12]  Timothy G. Constandinou,et al.  Autonomous SoC for Neural Local Field Potential Recording in mm-Scale Wireless Implants , 2018, 2018 IEEE International Symposium on Circuits and Systems (ISCAS).

[13]  Klaus-Dieter Lang,et al.  Wafer level packaging of MEMS and 3D integration with CMOS for fabrication of timing microsystems , 2016, 2016 Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP).

[14]  Ellis Meng,et al.  Materials for microfabricated implantable devices: a review. , 2015, Lab on a chip.

[15]  C. Bosshard,et al.  Au-Sn Transient Liquid Phase bonding for hermetic sealing and getter activation , 2013, European Microelectronics and Packaging Conference.

[16]  Andreas Demosthenous,et al.  Technology for integrated circuit micropackages for neural interfaces, based on gold–silicon wafer bonding , 2013 .

[17]  Arianna Menciassi,et al.  Microtechnologies in medicine: An overview , 2007, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[18]  Uda Hashim,et al.  The Effects of Multiple Zincation Process on Aluminum Bond Pad Surface for Electroless Nickel Immersion Gold Deposition , 2006 .

[19]  P. Atanassov,et al.  Electrodeposition of gold particles on aluminum substrates containing copper. , 2005, The journal of physical chemistry. B.

[20]  Paul Conway,et al.  Electroless nickel bumping of aluminum bondpads. II. Electroless nickel plating , 2002 .

[21]  Paul Conway,et al.  Electroless nickel bumping of aluminum bondpads. I. Surface pretreatment and activation , 2002 .

[22]  X. Chen,et al.  Electroless nickel bath for wafer bumping: influence of additives , 2000, International Symposium on Electronic Materials and Packaging (EMAP2000) (Cat. No.00EX458).

[23]  Hideo Honma,et al.  Fabrication of Nickel Microbump on Aluminum using Electroless Nickel Plating , 1997 .

[24]  Kwang-Lung Lin,et al.  The morphologies and the chemical states of the multiple zincating deposits on Al pads of Si chips , 1996 .

[25]  Andre M. T. van der Putten,et al.  Anisotropic Deposition of Electroless Nickel Bevel Plating , 1993 .

[26]  Hugh J. McDermott,et al.  An advanced multiple channel cochlear implant , 1989, IEEE Transactions on Biomedical Engineering.

[27]  M. Starink,et al.  IMPACT OF SINGLE AND DOUBLE ZINCATING TREATMENT ON ADHESION OF ELECTRODEPOSITED NICKEL COATING ON ALUMINIUM ALLOY 7075 , 2018 .

[28]  Diana Hodgins,et al.  Implantable sensor systems for medical applications , 2013 .

[29]  T. Stieglitz,et al.  Microassembly and micropackaging of implantable systems , 2013 .

[30]  S. Costello,et al.  Review of test methods used for the measurement of hermeticity in packages containing small cavities , 2010 .

[31]  Guangqiang Jiang,et al.  Technology Advances and Challenges in Hermetic Packaging for Implantable Medical Devices , 2009 .

[32]  K. Wefers,et al.  Oxides and Hydroxides of Aluminum , 2003 .

[33]  Paul Conway,et al.  Electroless nickel bumping of aluminium bondpads. Part 1 - surface pre-treatment and activation , 2002 .