Automatic Identification and Quantification of Metabolites in H-NMR Measurements

Stem cells therapy is currently at the frontier of biomedical research. A better understanding of the metabolism of stem cells is necessary to improve and extend initial promising results. Nuclear Magnetic Resonance Spectroscopy (NMR) allows for a precise measurement of metabolites in cell extracts. The identification and quantification of these metabolites is essential to model cellular metabolic network activity. To meet clinical standards and high throughput demands a full automatic evaluation is required. A NMR signal processing system is presented and initial results for the identification and quantification of metabolites from murine hematopoietic progenitor cell extracts (FDCPmix cells) and simulated spectra are given.