Pathology of the formalin-treated heterograft porcine aortic valve in the mitral position

The mitral valve was replaced by a pig aortic valve in 33 patients at Groote Schuur Hospital. Eleven of the failed heterograft aortic valves were examined at intervals of from 2 to 32 months after insertion. Fourteen control pig aortic valves were also examined. Electron microscopy was performed on two of the failed heterograft valves and three control pig valves. Failure of the heterograft was due to stretching and deformation of the cusps with resultant valvular incompetence. Stretching of the cusp was a result of reduction in the amount of its collagen content. The elastic tissue appeared little altered. A microscopic layer of fibrin thrombus was present on the surface of 8 of the 11 valves. Only 2 of the 11 valves showed invasion of the graft by immunologically competent cells. No valve showed any sign of infection or calcification. The denatured collagen of the heterograft has a low antigenicity and also, infortunately, a limited durability.

[1]  J. Kastor,et al.  Connective tissue abnormalities in spontaneous rupture of chordae tendineae. , 1971, Archives of pathology.

[2]  G. Primo,et al.  Autologous fascia lata cardiac valve replacement , 1971, Thorax.

[3]  D. Ross,et al.  Viability of autologous fascia lata in heart valve replacements , 1971, Thorax.

[4]  A. Gunning,et al.  Preservation and function of heterologous aortic valves , 1971, Thorax.

[5]  R. Pérez-Tamayo.  Collagen resorption in carrageenin granulomas. II. Ultrastructure of collagen resorption. , 1970, Laboratory investigation; a journal of technical methods and pathology.

[6]  W. Welch.  A comparative study of different methods of processing aortic homografts , 1969, Thorax.

[7]  L Robert,et al.  Biological factors affecting long-term results of valvular heterografts. , 1969, The Journal of thoracic and cardiovascular surgery.

[8]  K. A. Merendino,et al.  Pathological Changes in Human Aortic Valve Homografts , 1969, Circulation.

[9]  G. Lazarus,et al.  Degradation of collagen by a human granulocyte collagenolytic system. , 1968, The Journal of clinical investigation.

[10]  M. Ionescu,et al.  Heart valve replacement with reinforced aortic heterografts. Technique and results. , 1968, Journal of Thoracic and Cardiovascular Surgery.

[11]  D N Ross,et al.  Homograft replacement of the aortic valve. A clinical and pathologic study. , 1968, The American journal of cardiology.

[12]  I. R. Mcdonald,et al.  HETEROGRAFT AORTIC VALVE REPLACEMENT , 1968, The Medical journal of Australia.

[13]  K. A. Merendino,et al.  A biologic study of the homologous aortic valve in dogs. , 1967, The Journal of thoracic and cardiovascular surgery.

[14]  H. Hirsch.  Persistence of aortic-valve homografts. , 1967, Lancet.

[15]  M. O'brien,et al.  Heterograft aortic-valve replacement. , 1967, Lancet.

[16]  C. Duran,et al.  Heterologous aortic valve transplantation. , 1966, Lancet.

[17]  David A. Hall,et al.  International review of connective tissue research , 1963 .

[18]  R. Perez-Tamayo,et al.  Studies on uterine collagen during pregnancy and puerperium. , 1961, Laboratory investigation; a journal of technical methods and pathology.

[19]  '. JUDITHC.SMITH,et al.  The pathology of human aortic valve homografts , 2022 .