Diagnosic system for predicting bladder cancer recurrence using association rules

In this work we present a method based on association rules for the prediction of bladder cancer recurrence. Our objective is to provide a system which is on one hand comprehensible and on the other hand with a high sensitivity. Since data are not equitably distributed among the classes and since errors costs are asymmetric, we propose to handle separately the cases of recurrence and those of no-recurrence. Association rules are generated from each training set, using CBA algorithm, an associative classification approach. To represent the rules uncertainty, each rule is accompanied by a confidence degree estimated during the generation phase. Several symptoms of low intensity can be complementary and mutually reinforcing. This phenomenon is taken into account thanks to aggregate functions which strengthen the confidence degrees of the fired rules. The experimental results are very satisfactory and the sensibility rates are improved in comparison with some other approaches. In addition, interesting extracted knowledge was provided to oncologists.

[1]  A. Trabelsi,et al.  Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie. , 2012, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

[2]  Laura Schweitzer,et al.  Advances In Kernel Methods Support Vector Learning , 2016 .

[3]  S. Weber A general concept of fuzzy connectives, negations and implications based on t-norms and t-conorms , 1983 .

[4]  Didier Dubois,et al.  A review of fuzzy set aggregation connectives , 1985, Inf. Sci..

[5]  Alberto Maria Segre,et al.  Programs for Machine Learning , 1994 .

[6]  J. Chang-Claude,et al.  Cigarette smoking and bladder cancer in men: A pooled analysis of 11 case‐control studies , 2000, International journal of cancer.

[7]  Amihai Motro,et al.  Imprecision and Uncertainty in Database Systems , 1995 .

[8]  J. Ross Quinlan,et al.  C4.5: Programs for Machine Learning , 1992 .

[9]  K Ramesh Kumar,et al.  Class Association Rules based Feature Selection for Diagnosis of Dravet Syndrome , 2014 .

[10]  Sandy Maumus,et al.  Fouille de données biomédicales complexes : extraction de règles et de profils génétiques dans le cadre de l'étude du syndrome métabolique , 2005 .

[11]  Pat Langley,et al.  Estimating Continuous Distributions in Bayesian Classifiers , 1995, UAI.

[12]  Ian H. Witten,et al.  Generating Accurate Rule Sets Without Global Optimization , 1998, ICML.

[13]  Didier Gourc,et al.  Where Do We Stand with Fuzzy Project Scheduling , 2004 .

[14]  Anirban P. Mitra,et al.  Superficial bladder cancer: an update on etiology, molecular development, classification, and natural history. , 2008, Reviews in urology.

[15]  Peter Reutemann,et al.  WEKA Manual for Version 3-6-10 , 2008 .

[16]  Jian Pei,et al.  CMAR: accurate and efficient classification based on multiple class-association rules , 2001, Proceedings 2001 IEEE International Conference on Data Mining.

[17]  Ming-Yih Lee,et al.  Entropy-based feature extraction and decision tree induction for breast cancer diagnosis with standardized thermograph images , 2010, Comput. Methods Programs Biomed..

[18]  Wynne Hsu,et al.  Integrating Classification and Association Rule Mining , 1998, KDD.

[19]  Lin-li Zhu,et al.  Research on Uncertain Knowledge Representation and Processing in the Expert System , 2011, 2011 Fourth International Symposium on Knowledge Acquisition and Modeling.

[20]  C. Goose,et al.  Glossary of Terms , 2004, Machine Learning.

[21]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[22]  Taylor Murray,et al.  Cancer Statistics, 2001 , 2001, CA: a cancer journal for clinicians.

[23]  Thomas G. Dietterich What is machine learning? , 2020, Archives of Disease in Childhood.

[24]  J. Ross Quinlan,et al.  Simplifying decision trees , 1987, Int. J. Hum. Comput. Stud..

[25]  William W. Cohen Fast Effective Rule Induction , 1995, ICML.

[26]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[27]  Dimitrios I. Fotiadis,et al.  An association rule mining-based methodology for automated detection of ischemic ECG beats , 2006, IEEE Transactions on Biomedical Engineering.