Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target
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Xiaoling Xu | C. Cluzeau | F. Porter | C. Wassif | S. Mitra | I. Williams | Rong Li | A. Cougnoux | R. Li | K. Burkert | X. Xu | W. Zheng | Suman Mitra | Wei Zheng | Ian M. Williams | Kathryn R. Burkert
[1] C. Ponting,et al. High Incidence of Unrecognized Visceral/Neurological Late-onset Niemann-Pick Disease, type C1 Predicted by Analysis of Massively Parallel Sequencing Data Sets , 2015, Genetics in Medicine.
[2] F. Platt,et al. Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice , 2014, Neurobiology of Disease.
[3] R. Jaenisch,et al. Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells , 2014, Stem cell reports.
[4] W. Graier,et al. Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells* , 2014, The Journal of Biological Chemistry.
[5] Mackenzie W. Mathis,et al. Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS , 2014, Neuron.
[6] N. Faux,et al. Altered transition metal homeostasis in Niemann-Pick disease, type C1. , 2014, Metallomics : integrated biometal science.
[7] F. Platt,et al. RIPK3 as a potential therapeutic target for Gaucher's disease , 2014, Nature Medicine.
[8] P. Blank,et al. Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1 , 2014, Journal of Inherited Metabolic Disease.
[9] R. Jaenisch,et al. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. , 2013, Cell reports.
[10] D. Watkins-Chow,et al. Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1. , 2013, Human molecular genetics.
[11] Junying Yuan,et al. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. , 2013, Bioorganic & medicinal chemistry letters.
[12] A. Degterev,et al. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase , 2012, Cell Death and Differentiation.
[13] A. Lieberman,et al. Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. , 2012, Human molecular genetics.
[14] P. Vandenabeele,et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models , 2012, Cell Death and Disease.
[15] O. Wiest,et al. Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts , 2012, PloS one.
[16] G. Prendergast,et al. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity , 2012, Immunological reviews.
[17] Forbes D Porter,et al. Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1. , 2012, Human molecular genetics.
[18] R A Knight,et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 , 2011, Cell Death and Differentiation.
[19] Y. Zhang,et al. Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease , 2011, Cell Death and Disease.
[20] Xingshun Xu,et al. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury , 2010, Brain Research.
[21] Junying Yuan,et al. Necroptosis as an alternative form of programmed cell death. , 2010, Current opinion in cell biology.
[22] M. Patterson,et al. Miglustat in adult and juvenile patients with Niemann-Pick disease type C: long-term data from a clinical trial. , 2010, Molecular genetics and metabolism.
[23] D. Ory,et al. Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression , 2009, PloS one.
[24] W. Pavan,et al. Linear clinical progression, independent of age of onset, in Niemann–Pick disease, type C , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[25] J. Repa,et al. Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1−/− mouse , 2009, Proceedings of the National Academy of Sciences.
[26] A. Galione,et al. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium , 2008, Nature Medicine.
[27] M. Moskowitz,et al. Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[28] Alexei Degterev,et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. , 2008, Nature chemical biology.
[29] F. Ujjainwalla,et al. Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake , 2008, Molecular Pharmacology.
[30] M. Patterson,et al. Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study , 2007, The Lancet Neurology.
[31] R. Campenot,et al. Inflammation in the Niemann‐Pick type‐C brain , 2007 .
[32] A. Degterev,et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. , 2007, Bioorganic & medicinal chemistry letters.
[33] Y. Ioannou,et al. Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain , 2007, The Journal of Neuroscience.
[34] Alexei Degterev,et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury , 2005, Nature chemical biology.
[35] J. Lee,et al. Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus–hippocampal noradrenergic pathway , 2004, Neuroscience.
[36] S. Walkley,et al. Consequences of NPC1 and NPC2 loss of function in mammalian neurons. , 2004, Biochimica et biophysica acta.
[37] R. Dwek,et al. Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport* , 2004, Journal of Biological Chemistry.
[38] A. Granholm,et al. Minocycline protects basal forebrain cholinergic neurons from mu p75‐saporin immunotoxic lesioning , 2004, The European journal of neuroscience.
[39] S. Ohara,et al. Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann–Pick disease type C , 2004, Experimental Neurology.
[40] O. Bernard,et al. Studies on neuronal death in the mouse model of Niemann‐Pick C disease , 2002, Journal of neuroscience research.
[41] S. Walkley,et al. Critical role for glycosphingolipids in Niemann-Pick disease type C , 2001, Current Biology.
[42] D. German,et al. Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann‐Pick C disease , 2001, The Journal of comparative neurology.
[43] R. Brady,et al. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[44] W. Pavan,et al. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. , 1997, Science.
[45] T. Vanden Berghe,et al. Programmed necrosis from molecules to health and disease. , 2011, International review of cell and molecular biology.
[46] A. Degterev,et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. , 2008, Bioorganic & medicinal chemistry letters.
[47] G. Weissmann. Americans sweep Nobel Prizes: thinking inside and outside the box. , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[48] R. Proia,et al. Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. , 2005, Molecular genetics and metabolism.
[49] S. Murayama,et al. Cerebellar degeneration in the Niemann-Pick type C mouse , 2004, Acta Neuropathologica.