Review article Supported by a grant from Astra Zeneca Pharmaceuticals

[1]  G. Pershagen,et al.  Atopy in children of families with an anthroposophic lifestyle , 1999, The Lancet.

[2]  T. Mosmann,et al.  Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? , 1993, Immunology today.

[3]  M. Piccinni,et al.  Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions , 1998, Nature Medicine.

[4]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[5]  H. Helenius,et al.  Farm environment in childhood prevents the development of allergies , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[6]  G. Berry,et al.  CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. , 2000, The Journal of clinical investigation.

[7]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[8]  C. Mackay,et al.  Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. , 1997, Science.

[9]  P. Nickerson,et al.  Cytokines and the Th1/Th2 paradigm in transplantation. , 1994, Current opinion in immunology.

[10]  G. Sempowski,et al.  Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. , 1994, Journal of immunology.

[11]  K. Sugamura,et al.  Selective expression of a novel surface molecule by human Th2 cells in vivo. , 1999, Journal of immunology.

[12]  B. Stripp,et al.  Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. , 1994, The Journal of clinical investigation.

[13]  P. Allavena,et al.  Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.

[14]  S. Romagnani,et al.  Regulation of the development of type 2 T-helper cells in allergy. , 1994, Current opinion in immunology.

[15]  G. Fantuzzi,et al.  Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. , 1999, Immunity.

[16]  E. Mutius,et al.  Reduced risk of hay fever and asthma among children of farmers , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[17]  M. Biffi,et al.  Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells , 1997, Journal of Experimental Medicine.

[18]  O. Lantz,et al.  Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells , 1996, The Journal of experimental medicine.

[19]  Chyung-Ru Wang,et al.  Helper T cell differentiation is controlled by the cell cycle. , 1998, Immunity.

[20]  W. Ouyang,et al.  The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. de Carli,et al.  Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. , 1992, Journal of immunology.

[22]  P. Pandolfi,et al.  The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation , 1997, Nature Genetics.

[23]  E. Maggi,et al.  Redirecting Th2 responses in allergy. , 1999, Current topics in microbiology and immunology.

[24]  L. Cosmi,et al.  Molecules associated with human Th1 or Th2 cells. , 1998, European cytokine network.

[25]  Kenneth M. Murphy,et al.  Functional diversity of helper T lymphocytes , 1996, Nature.

[26]  F. Annunziato,et al.  Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. , 1995, Journal of immunology.

[27]  J. Bluestone,et al.  CD28/B7 system of T cell costimulation. , 1996, Annual review of immunology.

[28]  J. Sodroski,et al.  The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry , 1996, Nature.

[29]  Richard A Flavell,et al.  The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.

[30]  L. Cosmi,et al.  Enhanced HIV expression during Th2‐oriented responses explained by the opposite regulatory effect of IL‐4 and IFN‐γ on fusin/CXCR4 , 1998, European journal of immunology.

[31]  G. Canonica,et al.  Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. , 1998, The Journal of clinical investigation.

[32]  T. Haahtela,et al.  Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions. , 1999, The Journal of allergy and clinical immunology.

[33]  H. Katai,et al.  Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. , 1992, The Journal of clinical investigation.

[34]  S. Romagnani.  The role of lymphocytes in allergic disease. , 2000, The Journal of allergy and clinical immunology.

[35]  A. Kelso,et al.  Nature versus nurture in T cell cytokine production , 1999, Journal of leukocyte biology.

[36]  C. Hsieh,et al.  Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. , 1993, Science.

[37]  M. de Carli,et al.  IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. , 1992, Journal of immunology.

[38]  Teran Lm.  Chemokines and IL-5: major players of eosinophil recruitment in asthma. , 1999 .

[39]  S. Durham,et al.  The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. , 1999, Immunology today.

[40]  Y. Koide,et al.  Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages , 1997, Infection and immunity.

[41]  S. Arya,et al.  Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells , 1995, Science.

[42]  W. Eder,et al.  Austrian children living on a farm have less hay fever, asthma and allergic sensitization , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[43]  R. Homer,et al.  Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. , 1999, The Journal of clinical investigation.

[44]  A. Ray,et al.  Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. , 1999, The Journal of clinical investigation.

[45]  M. Clerici,et al.  A TH1-->TH2 switch is a critical step in the etiology of HIV infection. , 1993, Immunology today.

[46]  S. Szabo,et al.  Genes that regulate interleukin-4 expression in T cells. , 1997, Current opinion in immunology.

[47]  D. Metcalfe,et al.  Eotaxin potentiates antigen-dependent basophil IL-4 production. , 1999, Journal of immunology.

[48]  P. Matricardi,et al.  Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis a virus , 1997, BMJ.

[49]  M. Jordana,et al.  Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. , 1996, American journal of respiratory cell and molecular biology.

[50]  W. Paul,et al.  Lymphocyte responses and cytokines , 1994, Cell.

[51]  L. Glimcher,et al.  The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. , 1999, Immunity.

[52]  E. Mutius,et al.  The environmental predictors of allergic disease. , 2000 .

[53]  S. Constant,et al.  Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. , 1997, Annual review of immunology.

[54]  L. Glimcher,et al.  Transcription Factors in Lymphocyte Development— T and B Cells Get Together , 1999, Cell.

[55]  G. Trinchieri,et al.  Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.

[56]  S. Romagnani,et al.  The Th1/Th2 paradigm. , 1997, Immunology today.

[57]  A. Matucci,et al.  New advances in the pathogenesis and therapy of bronchial asthma. , 1998, Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna.

[58]  F. Annunziato,et al.  Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. , 1999, The American journal of pathology.

[59]  H. Lee,et al.  GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. , 1999, Clinical immunology.

[60]  D. Umetsu,et al.  Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production. , 1998, The Journal of allergy and clinical immunology.

[61]  C. Mackay,et al.  Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. , 1997, The Journal of clinical investigation.

[62]  P. Holt,et al.  A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. , 1999, American journal of respiratory cell and molecular biology.

[63]  S. Wenzel,et al.  Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. , 1999, The Journal of clinical investigation.

[64]  M. Baggiolini.  Chemokines and leukocyte traffic , 1998, Nature.

[65]  R. Homer,et al.  Airway remodeling in asthma. , 1999, The Journal of clinical investigation.

[66]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[67]  F. Martinez,et al.  Maturation of immune responses at the beginning of asthma. , 1999, The Journal of allergy and clinical immunology.

[68]  S. Romagnani.  Lymphokine production by human T cells in disease states. , 1994, Annual review of immunology.

[69]  N. Boiani,et al.  Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin‐2‐induced interleukin‐12 and interferon‐γ production , 1996, European journal of immunology.

[70]  P. Hogan,et al.  Transcription factors of the NFAT family: regulation and function. , 1997, Annual review of immunology.

[71]  T. Nicolai,et al.  Skin test reactivity and number of siblings , 1994, BMJ.

[72]  M. Neurath,et al.  Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes , 1998, The Journal of Immunology.

[73]  The Inverse Association Between Tuberculin Responses and Atopic Disorder , 1997, Science.

[74]  C. Mackay,et al.  High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. , 1997, The Journal of clinical investigation.

[75]  S. Romagnani.  The Th1-Th2 paradigm in disease , 1996 .