Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin.

[1]  U. Chaisri,et al.  Improvement of Function and Morphology of Tumor Necrosis Factor-α Treated Endothelial Cells With 17-β Estradiol , 2005 .

[2]  C. Napoli,et al.  Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis , 2005, Current atherosclerosis reports.

[3]  T. Takano,et al.  Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system. , 2004, Circulation journal : official journal of the Japanese Circulation Society.

[4]  K. Koh,et al.  Vascular effects of diet and statin in hypercholesterolemic patients. , 2004, International journal of cardiology.

[5]  L. Ignarro,et al.  Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. , 2004, Cardiovascular research.

[6]  Y. Kagaya,et al.  Characteristics and 1-year prognosis of medically treated patients with chronic heart failure in Japan. , 2003, Circulation journal : official journal of the Japanese Circulation Society.

[7]  J. Cooke Flow, NO, and atherogenesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Toshio Hayashi,et al.  Standardization of Plasma Brain Natriuretic Peptide Concentrations in Older Japanese—Relationship to Latent Renal Dysfunction and Ischemic Heart Disease , 2002, Journal of the American Geriatrics Society.

[9]  Takashi Sugamori,et al.  Increased nitric oxide in proportion to the severity of heart failure in patients with dilated cardiomyopathy: close correlation of tumor necrosis factor-alpha with systemic and local production of nitric oxide. , 2002, Circulation journal : official journal of the Japanese Circulation Society.

[10]  Toshio Hayashi,et al.  The Long‐Term Effect of Estriol on Endothelial Function and Bone Mineral Density in Octogenarian Women , 2002, Journal of the American Geriatrics Society.

[11]  Yutaka Seino,et al.  Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. , 2002, Diabetes research and clinical practice.

[12]  Suzanne G. Leveille,et al.  The Value of Serum Albumin and High‐Density Lipoprotein Cholesterol in Defining Mortality Risk in Older Persons with Low Serum Cholesterol , 2001, Journal of the American Geriatrics Society.

[13]  K. Egashira,et al.  Cerivastatin, a Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, Improves Endothelial Function in Elderly Diabetic Patients Within 3 Days , 2001, Circulation.

[14]  Toshio Hayashi,et al.  Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries. , 2000, Nitric oxide : biology and chemistry.

[15]  Toshio Hayashi,et al.  Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[16]  D. Garbers,et al.  The guanylyl cyclase receptors. , 1994, Zygote.

[17]  M. Kinoshita,et al.  Plasma brain natriuretic peptide level as a biochemical marker of morbidity and mortality in patients with asymptomatic or minimally symptomatic left ventricular dysfunction. Comparison with plasma angiotensin II and endothelin-1. , 1999, European heart journal.

[18]  Toshio Hayashi,et al.  A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA. , 1999, Biochemical and biophysical research communications.

[19]  Luigi Ferrucci,et al.  Serum IL‐6 Level and the Development of Disability in Older Persons , 1999, Journal of the American Geriatrics Society.

[20]  H. Cohen,et al.  Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. , 1999, The American journal of medicine.

[21]  J. Ix,et al.  The Predictive Value of Combined Hypoalbuminemia and Hypocholesterolemia in High Functioning Community‐Dwelling Older Persons: MacArthur Studies of Successful Aging , 1999, Journal of the American Geriatrics Society.

[22]  R. Ross,et al.  Atherosclerosis is an inflammatory disease. , 1998, American heart journal.

[23]  M. Ketteler,et al.  Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists. , 1998, Kidney international. Supplement.

[24]  D. Fukai,et al.  Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. , 1998, Journal of the American College of Cardiology.

[25]  D. Fukai,et al.  Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. , 1997, Circulation.

[26]  M. Kuzuya,et al.  Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits. , 1997, Atherosclerosis.

[27]  O. Febo,et al.  Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. , 1995, Circulation.

[28]  G. Greendale,et al.  Nutrition Screening in Older Persons , 1995, Journal of the American Geriatrics Society.

[29]  J. Cleland,et al.  Enhanced basal nitric oxide production in heart failure: another failed counter-regulatory vasodilator mechanism? , 1994, The Lancet.

[30]  P. Macdonald,et al.  Increased nitric oxide production in heart failure , 1994, The Lancet.

[31]  M. Herold,et al.  Increased levels of serum neopterin and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha. , 1993, Journal of the American College of Cardiology.

[32]  E. Fleck,et al.  Local regulation of vascular tone by bradykinin and angiotensin converting enzyme inhibitors. , 1993, European heart journal.

[33]  S. Takahashi,et al.  Using microparticle labeling and counting for attomole-level detection in heterogeneous immunoassay. , 1992, Analytical biochemistry.

[34]  H. Hidaka,et al.  Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators. , 1991, Atherosclerosis.

[35]  H. Imura,et al.  Increased human brain natriuretic peptide in congestive heart failure. , 1990, The New England journal of medicine.

[36]  H. Fillit,et al.  Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. , 1990, The New England journal of medicine.

[37]  D. Goeddel,et al.  A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor , 1989, Nature.

[38]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[39]  R. Gerzer,et al.  Rapid increase in plasma and urinary cyclic GMP after bolus injection of atrial natriuretic factor in man. , 1985, The Journal of clinical endocrinology and metabolism.