Principles of Simulated Moving Bed

In this chapter the principles of simulated moving bed technology are presented, starting with the history of chromatography and the progress from batch to continuous chromatography (true moving bed, TMB, and simulated moving bed, SMB). The basic equation (De Vault equation) to understand adsorption is derived and a simple design method for binary separations based on the equilibrium theory and linear adsorption isotherms is presented, leading to the representation of separation/regeneration regions. The equivalence between TMB and SMB is discussed in terms of equality of relative fluid velocities and the relation between switching time in SMB and solid velocity in TMB. Old and new applications of SMB from petrochemical and pharmaceutical industries are discussed as well as conventional and nonconventional modes of operation of SMB.

[1]  O Ludemann-Hombourger,et al.  Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate. , 2002, Journal of chromatography. A.

[2]  Phillip C. Wankat,et al.  Two-Zone SMB/Chromatography for Center-Cut Separation from Ternary Mixtures: Linear Isotherm Systems , 2006 .

[3]  L. Ettre.  The Centenary of Chromatography , 2003 .

[4]  Kus Hidajat,et al.  Optimization of Simulated Moving Bed and Varicol Processes for Glucose–Fructose Separation , 2003 .

[5]  Phillip C. Wankat,et al.  One-Column Chromatograph with Recycle Analogous to a Four-Zone Simulated Moving Bed , 2003 .

[6]  Anita M. Katti,et al.  Fundamentals of Preparative and Nonlinear Chromatography , 1994 .

[7]  Massimo Morbidelli,et al.  Optimal design of multicomponent countercurrent adsorption separation processes involving nonlinear equilibria , 1989 .

[8]  M. Mazzotti,et al.  Three column intermittent simulated moving bed chromatography: 1. Process description and comparative assessment. , 2014, Journal of chromatography. A.

[9]  L. A. van der Wielen,et al.  Novel simulated moving-bed method for reduced solvent consumption. , 2000, Journal of chromatography. A.

[10]  David W. Guest,et al.  Evaluation of simulated moving bed chromatography for pharmaceutical process development , 1997 .

[11]  D. Ruthven,et al.  Counter-current and simulated counter-current adsorption separation processes , 1989 .

[12]  A. Rodrigues,et al.  Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns. , 2003, Journal of chromatography. A.

[13]  A. Rodrigues,et al.  Outlet Stream Swing Simulated Moving Bed: Separation and Regeneration Regions Analysis , 2010 .

[14]  A. Rodrigues,et al.  Outlet Streams Swing (OSS) and MultiFeed Operation of Simulated Moving Beds , 2007 .

[15]  D. E. Rearick,et al.  Simulated Moving-Bed Technology in the Sweetener Industry , 1997 .

[16]  M. Morbidelli,et al.  Performance of a Six-Port Simulated Moving-Bed Pilot Plant for Vapor-Phase Adsorption Separations , 1992 .

[17]  Vera G. Mata,et al.  Separation of ternary mixtures by pseudo-simulated moving bed chromatography. , 2001, Journal of chromatography. A.

[18]  D. B. Broughton,et al.  Industrial Applications of Preparative Chromatography , 1981 .

[19]  José P B Mota,et al.  Experimental assessment of simulated moving bed and varicol processes using a single-column setup. , 2007, Journal of chromatography. A.

[20]  D. Devault.  The Theory of Chromatography , 1943 .

[21]  Michael Mccoy.  SMB EMERGES AS CHIRAL TECHNIQUE: Pharmaceutical chemical makers see method as new route to enantiomers , 2000 .

[22]  S. Engell,et al.  Optimal Operation of Continuous Chromatographic Processes: Mathematical Optimization of the VARICOL Process , 2002 .

[23]  S. Engell,et al.  Optimization of simulated moving bed and Varicol processes. , 2003, Journal of chromatography. A.

[24]  Kus Hidajat,et al.  Experimental study of a simulated counter-current adsorption system. III: Sorbex operation , 1985 .

[25]  Marco Mazzotti,et al.  Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. , 2010, Journal of chromatography. A.

[26]  Olivier Ludemann-Hombourger,et al.  The “VARICOL” Process: A New Multicolumn Continuous Chromatographic Process , 2000 .

[27]  Alírio E. Rodrigues,et al.  Simulated moving bed technology: old and new , 2006 .

[28]  D. B. Broughton.  Production-Scale Adsorptive Separations of Liquid Mixtures by Simulated Moving-Bed Technology , 1984 .

[29]  Massimo Morbidelli,et al.  Vapor-Phase SMB Adsorptive Separation of Linear/Nonlinear Paraffins , 1996 .

[31]  G. Brunner,et al.  Separation of stereoisomers in a simulated moving bed-supercritical fluid chromatography plant. , 1999, Journal of chromatography. A.

[32]  J. Calvin Giddings,et al.  Unified Separation Science , 1991 .

[33]  Massimo Morbidelli,et al.  Continuous enantiomer separation of the volatile inhalation anesthetic enflurane with a gas chromatographic simulated moving bed unit , 1998 .

[34]  Georges Guiochon,et al.  Analytical solution for the linear ideal model of simulated moving bed chromatography , 1996 .

[35]  George E. Keller,et al.  Separation Process Technology , 1997 .

[36]  Luís S. Pais,et al.  Modeling strategies for enantiomers separation by SMB chromatography , 1998 .

[37]  Alírio E. Rodrigues,et al.  Design of a gas phase simulated moving bed for propane/propylene separation , 2009 .

[38]  ADSORPTION SEPARATES XYLENES , 1973 .

[39]  Andreas Seidel-Morgenstern,et al.  Application of gradients in the simulated moving bed process , 2001 .

[40]  A. K. Ray,et al.  Multiobjective optimization of SMB and varicol process for chiral separation , 2002 .

[41]  Achim Kienle,et al.  Improving Simulated Moving Bed Processes by Cyclic Modulation of the Feed Concentration , 2002 .

[42]  G. Keller.  Adsorption : building upon a solid foundation , 1995 .

[43]  M. Bailly,et al.  The M3C Process: A New Multicolumn Chromatographic Process Integrating a Concentration Step. I—The Equilibrium Model , 2006 .

[44]  Douglas M. Ruthven,et al.  Principles of Adsorption and Adsorption Processes , 1984 .

[45]  J. Purnell.  Dynamics of chromatography, part I, principles and theory By J. Calvin Giddings. Pp. xii + 323, Edward Arnold, London. 1965. 90s , 1966 .

[46]  Kyung-Min Kim,et al.  Backfill-simulated moving bed operation for improving the separation performance of simulated moving bed chromatography. , 2013, Journal of chromatography. A.

[47]  Phillip C. Wankat,et al.  SMB Operation Strategy−Partial Feed , 2002 .

[48]  Massimo Morbidelli,et al.  PowerFeed operation of simulated moving bed units: changing flow-rates during the switching interval. , 2003, Journal of chromatography. A.

[49]  Phillip C. Wankat,et al.  Three-zone simulated moving bed with partial feed and selective withdrawal , 2002 .