Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate

Abstract In vitro, the transport of hydrocortisone acetate across a model synthetic membrane has been investigated. Subsaturated, saturated and supersaturated solutions of hydrocortisone acetate, formed by mixing appropriate propylene glycol/water cosolvent systems, were studied. Transport was linearly proportional to the degree of saturation over the wide range studied. Supersaturated systems have potential application in topical drug delivery especially when release from saturated solutions is limiting.

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