Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex

Multiple tubers in patients with tuberous sclerosis complex (TSC) often are responsible for drug‐resistant epilepsy. The complexity of the epileptic network formed by multiple tubers complicates localization of the epileptogenic zone that is needed to design a surgical treatment strategy. High frequency oscillations (HFOs) on intracranial video‐electroencephalography (IVEEG) may be a valuable surrogate marker for the localization of the epileptogenic zone. The purpose of this study was to test the hypothesis that high occurrence rate (OR) of interictal HFOs can guide the localization of the epileptogenic zone.

[1]  Fabrice Wendling,et al.  Mechanisms of physiological and epileptic HFO generation , 2012, Progress in Neurobiology.

[2]  O. Devinsky,et al.  Bilateral invasive electroencephalography in patients with tuberous sclerosis complex: a path to surgery? , 2011, Journal of neurosurgery. Pediatrics.

[3]  G. Ojemann,et al.  Surgical management and seizure outcome in patients with tuberous sclerosis. , 1997, Journal of neurosurgery.

[4]  M. Wong.  Mechanisms of Epileptogenesis in Tuberous Sclerosis Complex and Related Malformations of Cortical Development with Abnormal Glioneuronal Proliferation , 2008, Epilepsia.

[5]  Jean Gotman,et al.  Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG‐fMRI , 2008, Epilepsia.

[6]  Guglielmo Foffani,et al.  Emergent Dynamics of Fast Ripples in the Epileptic Hippocampus , 2010, The Journal of Neuroscience.

[7]  G. Holmes,et al.  Tuberous Sclerosis Complex and Epilepsy: Recent Developments and Future Challenges , 2007, Epilepsia.

[8]  Ayako Ochi,et al.  Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy , 2011, Epilepsia.

[9]  S. Spencer.  Neural Networks in Human Epilepsy: Evidence of and Implications for Treatment , 2002, Epilepsia.

[10]  E. Oka,et al.  Analysis of Ictal EEGs of Epilepsy Associated with Tuberous Sclerosis , 1998, Epilepsia.

[11]  Charles L. Wilson,et al.  Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. , 2002, Journal of neurophysiology.

[12]  D. Kwiatkowski,et al.  Tuberous sclerosis. , 1994, Archives of dermatology.

[13]  Andreas Schulze-Bonhage,et al.  Differentiation of specific ripple patterns helps to identify epileptogenic areas for surgical procedures , 2014, Clinical Neurophysiology.

[14]  A. V. van Huffelen,et al.  Epilepsy Surgery in Tuberous Sclerosis: A Systematic Review , 2007, Epilepsia.

[15]  P. Bolton,et al.  The Tuberous Sclerosis 2000 Study: presentation, initial assessments and implications for diagnosis and management , 2011, Archives of Disease in Childhood.

[16]  H. Lüders,et al.  Presurgical evaluation of epilepsy. , 2001, Brain : a journal of neurology.

[17]  E. Oka,et al.  Long‐Term Follow‐Up of Childhood Epilepsy Associated with Tuberous Sclerosis , 1998, Epilepsia.

[18]  M. Steriade,et al.  The role of chloride-dependent inhibition and the activity of fast-spiking neurons during cortical spike–wave electrographic seizures , 2002, Neuroscience.

[19]  H. Otsubo,et al.  Characterizing Magnetoencephalographic Spike Sources in Children with Tuberous Sclerosis Complex , 2005, Epilepsia.

[20]  Patient with Postcentral Gyrectomy Demonstrates Reliable Localization of Hand Motor Area Using Magnetoencephalography , 2009, Pediatric Neurosurgery.

[21]  H. Weiner,et al.  Tuberous Sclerosis and Multiple Tubers: Localizing the Epileptogenic Zone , 2004, Epilepsia.

[22]  T. Rasmussen,et al.  Surgical treatment of epilepsy in tuberous sclerosis , 1998, Neurology.

[23]  J. Drake,et al.  Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex. Clinical article. , 2009, Journal of neurosurgery. Pediatrics.

[24]  Ayako Ochi,et al.  Dynamic Changes of Ictal High‐Frequency Oscillations in Neocortical Epilepsy: Using Multiple Band Frequency Analysis , 2007, Epilepsia.

[25]  J. Klimo.  Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex , 2010 .

[26]  S. Nagarajan,et al.  Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex , 2010, Neurology.

[27]  Josef Kittler,et al.  Minimum error thresholding , 1986, Pattern Recognit..

[28]  J. Gotman,et al.  High‐frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery , 2010, Annals of neurology.

[29]  G. Guyatt,et al.  Predictors of Seizure Outcomes in Children with Tuberous Sclerosis Complex and Intractable Epilepsy Undergoing Resective Epilepsy Surgery: An Individual Participant Data Meta-Analysis , 2013, PloS one.

[30]  J. Gotman,et al.  Effect of sleep stage on interictal high‐frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy , 2009, Epilepsia.

[31]  O. Devinsky,et al.  Epilepsy Surgery in Young Children With Tuberous Sclerosis: Results of a Novel Approach , 2006, Pediatrics.

[32]  Ayako Ochi,et al.  High-frequency oscillations of ictal muscle activity and epileptogenic discharges on intracranial EEG in a temporal lobe epilepsy patient , 2008, Clinical Neurophysiology.

[33]  D. Roberts,et al.  Epilepsy surgery in tuberous sclerosis: a review. , 2012, Neurosurgical focus.

[34]  Ayako Ochi,et al.  Localization of epileptic foci in children with intractable epilepsy secondary to multiple cortical tubers by using synthetic aperture magnetometry kurtosis. , 2009, Journal of neurosurgery. Pediatrics.

[35]  J. Stockman.  The Tuberous Sclerosis 2000 Study: presentation initial assessments and implications for diagnosis and management , 2013 .

[36]  M. Duchowny,et al.  Epilepsy Surgery in Children with Tuberous Sclerosis Complex: Presurgical Evaluation and Outcome , 2000, Epilepsia.

[37]  Mirela V. Simon,et al.  Are cortical tubers epileptogenic? Evidence from electrocorticography , 2009, Epilepsia.

[38]  Charles L. Wilson,et al.  High‐frequency oscillations in human brain , 1999, Hippocampus.