论文信息 - Estimating the Number of Deaths with Rotavirus as a Cause in England and Wales

Estimating the Number of Deaths with Rotavirus as a Cause in England and Wales

The precise number of deaths due to rotavirus infection in England and Wales is difficult to determine because mortality is usually low and reported simply as death due to gastrointestinal disease. We have used two independent methods to estimate this figure. Firstly, we obtained records from the Office for National Statistics of deaths in children with any mention of gastroenteritis. For deaths with uncertain aetiology, we estimated the proportion attributable to rotavirus using a linear model with monthly laboratory reports of gastrointestinal micro-organisms as predictors. Secondly, we calculated the case-fatality ratio of records in Hospital Episode Statistics with rotavirus indicated, and applied this ratio to an estimate of the actual number of rotavirus hospital admissions. The two methods gave estimates of 3.8 and 3.2 rotavirus deaths a year respectively.

M. Jit | J. Edmunds | R. Pebody | N. Andrews | Mark Chen

[1] T. Vesikari,et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. , 2006, The New England journal of medicine.

[2] J. Heyse,et al. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. , 2006, The New England journal of medicine.

[3] Timo Vesikari,et al. Burden of Rotavirus Disease in European Union Countries , 2006, The Pediatric infectious disease journal.

[4] Mark A. Miller,et al. Global Illness and Deaths Caused by Rotavirus Disease in Children , 2003, Emerging infectious diseases.

[5] C. Farrington,et al. Hospital admissions attributable to rotavirus infection in England and Wales. , 1996, The Journal of infectious diseases.

[6] A. D. Grant,et al. Application of information technology to the laboratory reporting of communicable disease in England and Wales. , 1993, Communicable disease report. CDR review.