Real-time segmentation and tracking of brain metabolic state in ICU EEG recordings of burst suppression

We provide a method for estimating brain metabolic state based on a reduced-order model of EEG burst suppression. The model, derived from previously suggested biophysical mechanisms of burst suppression, describes important electrophysiological features and provides a direct link to cerebral metabolic rate. We design and fit the estimation method from EEG recordings of burst suppression from a neurological intensive care unit and test it on real and synthetic data.

[1]  Emery N Brown,et al.  A neurophysiological–metabolic model for burst suppression , 2012, Proceedings of the National Academy of Sciences.

[2]  N Löfgren,et al.  Classification of burst and suppression in the neonatal electroencephalogram , 2008, Journal of neural engineering.

[3]  P M Patel,et al.  A comparison of the electrophysiologic characteristics of EEG burst-suppression as produced by isoflurane, thiopental, etomidate, and propofol. , 1996, Journal of neurosurgical anesthesiology.

[4]  G. B. Young,et al.  The EEG in Coma , 2000, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[5]  Tapio Seppänen,et al.  Automatic Analysis and Monitoring of Burst Suppression in Anesthesia , 2002, Journal of Clinical Monitoring and Computing.

[6]  R Hall,et al.  Brain protection: physiological and pharmacological considerations. Part II: the pharmacology of brain protection , 1990, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[7]  S J Weiss,et al.  Deep hypothermic circulatory arrest: II. Changes in electroencephalogram and evoked potentials during rewarming. , 2001, The Annals of thoracic surgery.

[8]  Emery N. Brown,et al.  Real-time segmentation of burst suppression patterns in critical care EEG monitoring , 2013, Journal of Neuroscience Methods.

[9]  B. Rosner,et al.  Neurophysiologic Effects of General Anesthetics: I. The Electroencephalogram and Sensory Evoked Responses in Man , 1973, Anesthesiology.

[10]  Emery N. Brown,et al.  A state-space model of the burst suppression ratio , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[11]  Florin Amzica,et al.  Hypersensitivity of the Anesthesia-Induced Comatose Brain , 2007, The Journal of Neuroscience.

[12]  D. Contreras,et al.  Cortical and thalamic cellular correlates of electroencephalographic burst-suppression. , 1994, Electroencephalography and clinical neurophysiology.

[13]  Florin Amzica,et al.  Basic physiology of burst‐suppression , 2009, Epilepsia.