10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells.
暂无分享,去创建一个
[1] Simon C Watkins,et al. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver , 2001, Hepatology.
[2] O. Kallioniemi,et al. Tissue microarray technology for high-throughput molecular profiling of cancer. , 2001, Human molecular genetics.
[3] C. Wagner. BIOCHEMICAL ROLE OF FOLATE IN CELLULAR METABOLISM* , 2001 .
[4] L. Kluijtmans,et al. The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene. , 2000, Gene.
[5] L. Bailey,et al. Folate metabolism and requirements. , 1999, The Journal of nutrition.
[6] M. Rhee,et al. Glutamyl hydrolase: properties and pharmacologic impact. , 1999, Seminars in oncology.
[7] H. Calvert. An overview of folate metabolism: features relevant to the action and toxicities of antifolate anticancer agents. , 1999, Seminars in oncology.
[8] Krista A. Zanetti,et al. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene. , 1998, Gene.
[9] P. Hollenberg,et al. Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine. , 1998, Carcinogenesis.
[10] R. Moran,et al. Transcription of the Human Folylpoly-γ-glutamate Synthetase Gene* , 1997, The Journal of Biological Chemistry.
[11] S. Krupenko,et al. Expression, Purification, and Properties of the Aldehyde Dehydrogenase Homologous Carboxyl-terminal Domain of Rat 10-Formyltetrahydrofolate Dehydrogenase* , 1997, The Journal of Biological Chemistry.
[12] G. Michalopoulos,et al. Liver Regeneration , 1997, Science.
[13] S. Krupenko,et al. Cysteine 707 Is Involved in the Dehydrogenase Active Site of Rat 10-Formyltetrahydrofolate Dehydrogenase (*) , 1995, The Journal of Biological Chemistry.
[14] K. Champion,et al. Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[15] J. Ross,et al. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications , 1994, Cancer.
[16] M. Hentze,et al. Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains? , 1994, Trends in biochemical sciences.
[17] M. Rhee,et al. Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells. , 1992, Molecular pharmacology.
[18] R. Mackenzie,et al. Transcriptional regulation of murine NADP+‐dependent methylenetetrahydrofolate dehydrogenase‐cyclohydrolase‐synthetase , 1991, FEBS letters.
[19] G. P. Beardsley,et al. (6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid effects on nucleotide metabolism in CCRF-CEM human T-lymphoblast leukemia cells. , 1991, Cancer research.
[20] A. Tse,et al. Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. , 1991, Biochemistry.
[21] R. Moran,et al. A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. , 1989, The Journal of biological chemistry.
[22] R. Mackenzie,et al. Formyltetrahydrofolate dehydrogenase-hydrolase from pig liver: simultaneous assay of the activities. , 1986, Biochimica et biophysica acta.
[23] S. Benkovic,et al. The transformylase enzymes of de novo purine biosynthesis , 1984 .
[24] G. Weber. Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. , 1983, Cancer research.
[25] A. Clifford,et al. Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo. , 1981, The Journal of nutrition.
[26] A. Clifford,et al. Metabolism of orally and intravenously administered purines in rats. , 1980, The Journal of nutrition.
[27] M. Scrutton,et al. Inhibitory effects of histidine and their reversal. The roles of pyruvate carboxylase and N10-formyltetrahydrofolate dehydrogenase. , 1979, The Biochemical journal.
[28] J. Blair,et al. Effect of an implanted Walker tumour on metabolism of folic acid in the rat. , 1978, British Journal of Cancer.
[29] H. Krebs,et al. The regulation of folate and methionine metabolism. , 1976, The Biochemical journal.
[30] R. Kisliuk. Folate Biochemistry in Relation to Antifolate Selectivity , 1999 .
[31] David B. Krizman,et al. The genetics of cancer—a 3D model , 1999, Nature Genetics.
[32] S. Kaye,et al. New antimetabolites in cancer chemotherapy and their clinical impact. , 1998, British Journal of Cancer.
[33] D. Wilkinson. In situ hybridization: a practical approach , 1998 .
[34] A. Kinsella,et al. Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage. , 1997, British Journal of Cancer.
[35] N. Bucher. Liver regeneration then and now , 1995 .
[36] J. Bertino,et al. Karnofsky memorial lecture. Ode to methotrexate. , 1993, Journal of Clinical Oncology.
[37] J. C. Schmitz,et al. Folate metabolites as modulators of antitumor drug activity. , 1993, Advances in experimental medicine and biology.
[38] T. Tephly,et al. The toxicity of methanol. , 1991, Life sciences.
[39] F. Rudolph,et al. Role of RNA as a dietary source of pyrimidines and purines in immune function. , 1990, Nutrition.
[40] E. Stokstad,et al. [199] 10-Formyl tetrahydrofolate: NADP oxidoreductase , 1971 .