Electrospun poly-l-lactide scaffold for the controlled and targeted delivery of a synthetically obtained Diclofenac prodrug to treat actinic keratosis.

[1]  Amith,et al.  A Comprehensive Review Summarizing the Effect of Electrospinning Parameters and Potential Applications of Nanofibers , 2019 .

[2]  Limin Zhu,et al.  Controlled release from thermo-sensitive PNVCL-co-MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug. , 2016, Materials science & engineering. C, Materials for biological applications.

[3]  Deng-Guang Yu,et al.  Electrospun pH-sensitive core-shell polymer nanocomposites fabricated using a tri-axial process. , 2016, Acta biomaterialia.

[4]  Deng-Guang Yu,et al.  Electrospun zein nanoribbons for treatment of lead-contained wastewater , 2016 .

[5]  A. Widgerow,et al.  Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures. , 2016, Journal of drugs in dermatology : JDD.

[6]  Rubén M. Maggio,et al.  Preparation and Physical Characterization of a Diclofenac-Ranitidine Co-precipitate for Improving the Dissolution of Diclofenac. , 2016, Journal of pharmaceutical sciences.

[7]  P. White,et al.  Advances in Fmoc solid‐phase peptide synthesis , 2016, Journal of peptide science : an official publication of the European Peptide Society.

[8]  S. Haider,et al.  A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology , 2015, Arabian Journal of Chemistry.

[9]  Birgit Glasmacher,et al.  Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system , 2015 .

[10]  Yuyin Xu,et al.  Study of the in vitro cytotoxicity testing of medical devices. , 2015, Biomedical reports.

[11]  R. Altman,et al.  Advances in NSAID Development: Evolution of Diclofenac Products Using Pharmaceutical Technology , 2015, Drugs.

[12]  Eva Brauchle,et al.  Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine , 2015, Advanced healthcare materials.

[13]  Praven Chetty,et al.  Primary Care Review of Actinic Keratosis and Its Therapeutic Options: A Global Perspective , 2015, Dermatology and Therapy.

[14]  S. Bushuven,et al.  Diclofenac up2date – Teil 2: Einsatz bei speziellen Patientengruppen , 2014, Anästhesiol Intensivmed Notfallmed Schmerzther.

[15]  S. Bushuven,et al.  Diclofenac up2date – Teil 1: Die Pharmakologie und der Vergleich mit anderen Medikamenten , 2014, Anästhesiol Intensivmed Notfallmed Schmerzther.

[16]  D. Paneva,et al.  Polylactide (PLA)-Based Electrospun Fibrous Materials Containing Ionic Drugs as Wound Dressing Materials: A Review , 2014 .

[17]  N. Farhan,et al.  Evaluation of diclofenac prodrugs for enhancing transdermal delivery , 2014, Drug development and industrial pharmacy.

[18]  Katja Schenke-Layland,et al.  Engineering of a bio-functionalized hybrid off-the-shelf heart valve. , 2014, Biomaterials.

[19]  G. Goldenberg.  Optimal treatment of actinic keratosis , 2013, Clinical interventions in aging.

[20]  K. Schenke-Layland,et al.  Design and analysis of a squamous cell carcinoma in vitro model system. , 2013, Biomaterials.

[21]  A. Boccaccini,et al.  Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine , 2013, Journal of The Royal Society Interface.

[22]  Talbot Clifford,et al.  High‐resolution multiphoton tomography and fluorescence lifetime imaging of UVB‐induced cellular damage on cultured fibroblasts producing fibres , 2013, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[23]  G. Hays,et al.  Identification of genetically and oceanographically distinct blooms of jellyfish , 2013, Journal of The Royal Society Interface.

[24]  V. Pillay,et al.  A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications , 2013 .

[25]  Elizabeth E. Uhlenhake.  Optimal treatment of actinic keratoses , 2013, Clinical interventions in aging.

[26]  Z. Werb,et al.  Extracellular matrix degradation and remodeling in development and disease. , 2011, Cold Spring Harbor perspectives in biology.

[27]  E. Stockfleth,et al.  Modes of action of diclofenac 3%/hyaluronic acid 2.5% in the treatment of actinic keratosis , 2011, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[28]  Longqin Hu,et al.  Enzyme-mediated hydrolytic activation of prodrugs , 2011 .

[29]  Hirenkumar K. Makadia,et al.  Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. , 2011, Polymers.

[30]  Hannu Raunio,et al.  Prodrugs—from Serendipity to Rational Design , 2011, Pharmacological Reviews.

[31]  Katja Schenke-Layland,et al.  Raman spectroscopy: a noninvasive analysis tool for the discrimination of human skin cells. , 2011, Tissue engineering. Part C, Methods.

[32]  C. Nelson.  Diclofenac gel in the treatment of actinic keratoses , 2011, Therapeutics and clinical risk management.

[33]  B. Pourdeyhimi,et al.  Scaffolds for drug delivery, part I: electrospun porous poly(lactic acid) and poly(lactic acid)/poly(ethylene oxide) hybrid scaffolds , 2011 .

[34]  Katja Schenke-Layland,et al.  Skin tissue engineering--in vivo and in vitro applications. , 2011, Advanced drug delivery reviews.

[35]  P. Neuenschwander,et al.  Tuning electrospinning parameters for production of 3D-fiber-fleeces with increased porosity for soft tissue engineering applications. , 2011, European cells & materials.

[36]  A. Khademhosseini,et al.  Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density. , 2011, Journal of biomedical materials research. Part A.

[37]  Lei Jiang,et al.  Recent developments in bio-inspired special wettability. , 2010, Chemical Society reviews.

[38]  K. Hemminki,et al.  Incidence trends of squamous cell and rare skin cancers in the Swedish national cancer registry point to calendar year and age-dependent increases. , 2010, The Journal of investigative dermatology.

[39]  Prasanta Chowdhury,et al.  Kinetic modeling on drug release from controlled drug delivery systems. , 2010, Acta poloniae pharmaceutica.

[40]  Seyed Hassan Jafari,et al.  A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages , 2010 .

[41]  M. Sherratt,et al.  Tissue elasticity and the ageing elastic fibre , 2009, AGE.

[42]  G. Stavropoulos,et al.  2-Chlorotrityl chloride resin. Studies on anchoring of Fmoc-amino acids and peptide cleavage. , 2009, International journal of peptide and protein research.

[43]  Katja Schenke-Layland,et al.  Non‐invasive multiphoton imaging of extracellular matrix structures , 2008, Journal of biophotonics.

[44]  C. Laurencin,et al.  Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. , 2008, Biomaterials.

[45]  D. Rigel,et al.  Diclofenac sodium 3% gel in the treatment of actinic keratoses postcryosurgery. , 2008, Journal of drugs in dermatology : JDD.

[46]  Horst A von Recum,et al.  Electrospinning: applications in drug delivery and tissue engineering. , 2008, Biomaterials.

[47]  E. Huskisson,et al.  Topical diclofenac and its role in pain and inflammation: an evidence-based review , 2008, Current medical research and opinion.

[48]  C. Dong,et al.  Imaging tissue engineering scaffolds using multiphoton microscopy , 2008, Microscopy research and technique.

[49]  B. Hsiao,et al.  Functional electrospun nanofibrous scaffolds for biomedical applications. , 2007, Advanced drug delivery reviews.

[50]  J. Eberle,et al.  The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti‐inflammatory drugs (NSAIDs) , 2007, The British journal of dermatology.

[51]  H. Merk.  Topical diclofenac in the treatment of actinic keratoses , 2007, International journal of dermatology.

[52]  C. Lim,et al.  Mechanical properties of single electrospun drug-encapsulated nanofibres , 2006, Nanotechnology.

[53]  Abraham Marmur,et al.  Super-hydrophobicity fundamentals: implications to biofouling prevention , 2006, Biofouling.

[54]  Martin Brunner,et al.  Favourable dermal penetration of diclofenac after administration to the skin using a novel spray gel formulation. , 2005, British journal of clinical pharmacology.

[55]  S. Ramakrishna,et al.  Applications of polymer nanofibers in biomedicine and biotechnology , 2005, Applied biochemistry and biotechnology.

[56]  K. König,et al.  Multiphoton autofluorescence imaging of intratissue elastic fibers. , 2005, Biomaterials.

[57]  J. Jorizzo,et al.  Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. , 2004, Archives of dermatology.

[58]  J F Orr,et al.  Degradation of poly-L-lactide. Part 1: in vitro and in vivo physiological temperature degradation , 2004, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[59]  H. Korting,et al.  Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma , 2004, Skin Pharmacology and Physiology.

[60]  U. Boelsterli,et al.  Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. , 2003, Toxicology and applied pharmacology.

[61]  S. Caglar,et al.  Topical therapy for actinic keratoses, I: 5-Fluorouracil and imiquimod. , 2003, Cutis.

[62]  S. Caglar,et al.  Topical therapy for actinic keratoses, II: Diclofenac, colchicine, and retinoids. , 2003, Cutis.

[63]  J. Kelly,et al.  Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. , 2002, Journal of medicinal chemistry.

[64]  W. Hoekstra,et al.  The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox. , 2001, Current medicinal chemistry.

[65]  P. Gruber,et al.  Polylactic Acid Technology , 2000 .

[66]  Y. Kalia,et al.  Transdermal drug delivery: overcoming the skin's barrier function. , 2000, Pharmaceutical science & technology today.

[67]  R. Foster,et al.  Diclofenac/Hyaluronic Acid , 1999, Drugs & aging.

[68]  W. Baeyens,et al.  Diclofenac and naproxen analysis by microbore liquid chromatography (LC) with native fluorescence detection , 1995, Journal of Fluorescence.

[69]  J. G. Cory,et al.  Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. , 1991, Cancer communications.

[70]  N. Peppas,et al.  A simple equation for the description of solute release. III. Coupling of diffusion and relaxation , 1989 .

[71]  D. States,et al.  A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants☆ , 1982 .

[72]  J. Eisinger,et al.  Synthetic spectroscopic models related to coenzymes and base pairs. VII. Stacking interactions in tRNA; the "bend" at dimethylguanosine. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[73]  T. G. Scott,et al.  Synthetic spectroscopic models related to coenzymes and base pairs. V. Emission properties of NADH. Studies of fluorescence lifetimes and quantum efficiencies of NADH, AcPyADH, [reduced acetylpyridineadenine dinucleotide] and simplified synthetic models , 1970 .

[74]  L. Sidney,et al.  Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model. , 2015, Tissue engineering. Part A.

[75]  Masoud Latifi,et al.  Drug release profile in core-shell nanofibrous structures: A study on Peppas equation and artificial neural network modeling , 2014, Comput. Methods Programs Biomed..

[76]  S. Bushuven,et al.  [Diclofenac up2date - Part 1: Pharmacology and comparison with other drugs]. , 2014, Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.

[77]  Tarun Garg,et al.  Scaffold: a novel carrier for cell and drug delivery. , 2012, Critical reviews in therapeutic drug carrier systems.

[78]  A. Gupta,et al.  Synthesis and Evalution of Amide Prodrugs of Diclofenac , 2010 .

[79]  Tamotsu,et al.  Degradation of Poly(L-lactide) , 2010 .

[80]  G. Russo,et al.  Encapsulation of diclofenac molecules into poly (ε caprolactone) electrospun fibers for delivery protection , 2009 .

[81]  O. Corrigan,et al.  Release kinetics of benzoic acid and its sodium salt from a series of poly(N-isopropylacrylamide) matrices with various percentage crosslinking. , 2008, Journal of pharmaceutical sciences.

[82]  Albulescu Radu,et al.  In vitro biocompatibility testing of implantable biomaterials , 2008 .

[83]  M. Gómez-Lechón,et al.  Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. , 1999, The Journal of pharmacology and experimental therapeutics.

[84]  E. Grell,et al.  A new reagent for the cleavage of fully protected peptides synthesised on 2-chlorotrityl chloride resin , 1994 .

[85]  A. Ridolfo,et al.  Nonsteroidal anti-inflammatory agents. , 1979, Annual review of pharmacology and toxicology.