The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor

The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease.

[1]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. Furchgott,et al.  Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins. , 1985, The Journal of pharmacology and experimental therapeutics.

[3]  M. Gladwin,et al.  Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation , 2010, Drug Metabolism and Disposition.

[4]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[5]  L. Ignarro,et al.  Endothelium‐Derived Relaxing Factor From Pulmonary Artery and Vein Possesses Pharmacologic and Chemical Properties Identical to Those of Nitric Oxide Radical , 1987, Circulation research.

[6]  H. Oda,et al.  Nitrosyl-hemoglobin formation in the blood of animals exposed to nitric oxide. , 1975, Archives of environmental health.

[7]  Mark T. Gladwin,et al.  The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics , 2008, Nature Reviews Drug Discovery.

[8]  J. Stamler,et al.  Biochemistry of nitric oxide and its redox-activated forms. , 1992, Science.

[9]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[10]  J. S. Haldane,et al.  THE PRESENCE POST MORTEM OF NITRICOXIDE-HAEMOGLOBIN , 1925 .

[11]  S. Holzmann.  Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips. , 1982, Journal of cyclic nucleotide research.

[12]  R. Furchgott,et al.  Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. , 1985, The Journal of pharmacology and experimental therapeutics.

[13]  J. Loscalzo,et al.  N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. , 1985, The Journal of clinical investigation.

[14]  A. Mirsky,et al.  On the combination of nitric oxide with hæmoglobin , 1925, The Journal of physiology.

[15]  J. Stamler,et al.  Endogenous S-nitrosothiols protect against myocardial injury , 2009, Proceedings of the National Academy of Sciences.

[16]  F. Murad,et al.  Agonist‐Induced Endothelium‐Dependent Relaxation in Rat Thoracic Aorta May Be Mediated through cGMP , 1983, Circulation research.

[17]  J. Stamler,et al.  Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Loscalzo,et al.  S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. , 2013, Antioxidants & redox signaling.