Global stability in a delayed partial differential equation describing cellular replication

Here we consider the dynamics of a population of cells that are capable of simultaneous proliferation and maturation. The equations describing the cellular population numbers are first order partial differential equations (transport equations) in which there is an explicit temporal retardation as well as a nonlocal dependence in the maturation variable due to cell replication. The behavior of this system may be considered along the characteristics, and a global stability condition is proved.

[1]  O. Diekmann,et al.  The Dynamics of Physiologically Structured Populations , 1986 .

[2]  A. Lasota Stable and chaotic solutions of a first order partial differential equation , 1981 .

[3]  P. Brunovský Notes on chaos in the cell population partial differential equation , 1983 .

[4]  A. Lasota,et al.  Globally asymptotic properties of proliferating cell populations , 1984, Journal of mathematical biology.

[5]  I. Tannock,et al.  ON THE EXISTENCE OF A Go‐PHASE IN THE CELL CYCLE , 1970 .

[6]  Michael C. Mackey,et al.  Feedback, delays and the origin of blood cell dynamics , 1990 .

[7]  M. C. Mackey,et al.  Continuous maturation of proliferating erythroid precursors , 1982, Cell and tissue kinetics.

[8]  Michael C. Mackey,et al.  Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis , 1978 .

[9]  Mats Gyllenberg,et al.  An abstract delay-differential equation modelling size dependent cell growth and division , 1987 .

[10]  Odo Diekmann,et al.  On the stability of the cell size distribution , 1986 .

[11]  M C Mackey,et al.  Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis. , 1978, Blood.

[12]  Krzysztof Łoskot Turbulent solutions of a first order partial differential equation , 1985 .

[13]  Jozef Komorník,et al.  ASYMPTOTIC PERIODICITY OF THE ITERATES OF WEAKLY CONSTRICTIVE MARKOY OPERATORS , 1986 .

[14]  Michael C. Mackey,et al.  Dynamic Haematological Disorders of Stem Cell Origin , 1979 .

[15]  J. Smith,et al.  Do cells cycle? , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[16]  H. Walther An invariant manifold of slowly oscillating solutions for , 1991 .

[17]  Ergodicity and exactness of the shift on C[0, ∞) and the semiflow of a first-order partial differential equation , 1984 .

[18]  Michael C. Mackey,et al.  Solution multistability in first-order nonlinear differential delay equations. , 1993, Chaos.

[19]  Asymptotic periodicity of the iterates of Markov operators , 1984 .

[20]  J. Hale Theory of Functional Differential Equations , 1977 .

[21]  M. C. Mackey,et al.  Stability properties of proliferatively coupled cell replication models , 1991, Acta biotheoretica.

[22]  Michael C. Mackey,et al.  Bifurcations and traveling waves in a delayed partial differential equation. , 1992, Chaos.