Nitro-substituted aryl lithium compounds in microreactor synthesis: switch between kinetic and thermodynamic control.
暂无分享,去创建一个
[1] H. Löwe,et al. Chemistry in microstructured reactors. , 2004, Angewandte Chemie.
[2] Jun-ichi Yoshida,et al. Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor. , 2007, Journal of the American Chemical Society.
[3] Renato Dalpozzo,et al. The reaction of vinyl grignard reagents with 2-substituted nitroarenes: A new approach to the synthesis of 7-substituted indoles , 1989 .
[4] C. Bradsher,et al. Aromatic organolithium reagents bearing electrophilic groups. Preparation by halogen-lithium exchange , 1982 .
[5] P. Knochel,et al. Synthese hoch funktionalisierter Organomagnesiumreagentien durch Halogen-Metall-Austausch , 2003 .
[6] J. Bonjoch,et al. Total Synthesis of (-)-Strychnine via the Wieland-Gumlich Aldehyde. , 1999, Angewandte Chemie.
[7] P. Buck. Reaktionen aromatischer Nitroverbindungen mit Basen , 1969 .
[8] K. Mae,et al. Room-temperature Swern oxidations by using a microscale flow system. , 2005, Angewandte Chemie.
[9] T. Wirth,et al. Advanced organic synthesis using microreactor technology. , 2007, Organic & biomolecular chemistry.
[10] P. Knochel. Handbook of Functionalized Organometallics , 2005 .
[11] J. Yoshida. Flash chemistry using electrochemical method and microsystems. , 2005, Chemical communications.
[12] J. Gilmore,et al. Synthesis of 7-Formylindole Using the Bartoli Indole Methodology , 1992 .
[13] J. Kobayashi,et al. Multiphase organic synthesis in microchannel reactors. , 2006, Chemistry, an Asian journal.
[14] P. Knochel,et al. Highly functionalized organomagnesium reagents prepared through halogen-metal exchange. , 2003, Angewandte Chemie.
[15] Albert van den Berg,et al. On-microchip multiphase chemistry - a review of microreactor design principles and reagent contacting modes , 2005 .
[16] J. Yoshida,et al. Selective monolithiation of dibromobiaryls using microflow systems. , 2008, Organic letters.
[17] G. Köbrich,et al. Nachweis und Darstellung metallierter Nitroaromaten , 1970 .
[18] J. Yoshida,et al. Generation and Reactions of α-Silyloxiranyllithium in a Microreactor , 2009 .
[19] Jean M. J. Fréchet,et al. Photogeneration of organic bases from o-nitrobenzyl-derived carbamates , 1991 .
[20] Jeremy L. Steinbacher,et al. Greener approaches to organic synthesis using microreactor technology. , 2007, Chemical reviews.
[21] Aiichiro Nagaki,et al. Aryllithium compounds bearing alkoxycarbonyl groups: generation and reactions using a microflow system. , 2008, Angewandte Chemie.
[22] M. Schlosser. Der 2×3‐Werkzeugkasten der metallorganischen Methoden zur regiochemisch erschöpfenden Funktionalisierung , 2005 .
[23] Holger Löwe,et al. Chemie in Mikrostrukturreaktoren , 2004 .
[24] G. Bartoli,et al. Mechanistic studies on the reaction of nitro- and nitrosoarenes with vinyl Grignard reagents , 1991 .
[25] P. Knochel,et al. New Applications of Polyfunctional Organometallic Compounds in Organic Synthesis Frequently used abbreviations are defined at the end of the article. , 2000, Angewandte Chemie.
[26] A. deMello. Control and detection of chemical reactions in microfluidic systems , 2006, Nature.
[27] P. Baran,et al. Protecting-group-free synthesis as an opportunity for invention. , 2009, Nature chemistry.
[28] M. Cava,et al. Organotellurium chemistry. 3. (o-Nitrophenyl)tellurenyl bromide: a highly stabilized tellurenyl halide , 1979 .
[29] P. Knochel,et al. Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange. , 2005, The Journal of organic chemistry.
[30] Paul Watts,et al. Self-supported and clean one-step cathodic coupling of activated olefins with benzyl bromide derivatives in a micro flow reactor. , 2006, Angewandte Chemie.
[31] Shin-ichi Tanaka,et al. Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step. , 2007, Organic letters.
[32] P. Knochel,et al. General preparation of functionalized o-nitroarylmagnesium halides through an iodine-magnesium exchange. , 2002, Angewandte Chemie.
[33] Bosch,et al. Enantioselective total synthesis of Wieland-Gumlich aldehyde and (-)-strychnine , 2000, Chemistry.
[34] Paul Watts,et al. The application of micro reactors for organic synthesis. , 2005, Chemical Society reviews.
[35] P. Buck. Reactions of Aromatic Nitro Compounds with Bases , 1969 .
[36] P. Knochel,et al. Preparation of highly functionalized magnesium, zinc, and copper aryl and alkenyl organometallics via the corresponding organolithiums , 1992 .
[37] R. Gleiter,et al. Zur Thermolyse von o-Nitro-phenyllithium , 1970 .
[38] Helen Song,et al. Reaktionen in Mikrofluidiktröpfchen , 2006 .
[39] Peter H Seeberger,et al. Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? , 2006, Chemistry.
[40] P. Knochel,et al. Neue Anwendungen für polyfunktionalisierte Organometallverbindungen in der organischen Synthese , 2000 .
[41] Yoichi M. A. Yamada,et al. Instantaneous Carbon−Carbon Bond Formation Using a Microchannel Reactor with a Catalytic Membrane , 2006 .
[42] M. Schlosser. The 2 x 3 toolbox of organometallic methods for regiochemically exhaustive functionalization. , 2005, Angewandte Chemie.
[43] Jun-ichi Yoshida,et al. Flash chemistry: fast chemical synthesis by using microreactors. , 2008, Chemistry.
[44] K. Jensen,et al. Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. , 2007, Angewandte Chemie.
[45] J. Yoshida,et al. Oxiranyl anion methodology using microflow systems. , 2009, Journal of the American Chemical Society.
[46] Daniel Solé,et al. Totalsynthese von (−)‐Strychnin über den Wieland‐Gumlich‐Aldehyd , 1999 .
[47] Jun-ichi Yoshida,et al. Integrated micro flow synthesis based on sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes. , 2007, Chemistry, an Asian journal.
[48] M. Pirrung,et al. 7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction , 2002 .
[49] Helen Song,et al. Reactions in droplets in microfluidic channels. , 2006, Angewandte Chemie.
[50] G. C. Micalizio,et al. Total synthesis of macbecin I. , 2008, Angewandte Chemie.
[51] Christian H. Hornung,et al. A Microcapillary Flow Disc Reactor for Organic Synthesis , 2007 .
[52] J. Gilmore,et al. The Synthesis of 7-Alkoxyindoles , 1991 .
[53] J. Bonjoch,et al. A General Synthetic Entry to Strychnos Alkaloids of the Curan Type via a Common 3a-(2-Nitrophenyl)hexahydroindol-4-one Intermediate. Total Syntheses of (±)- and (−)-Tubifolidine, (±)-Akuammicine, (±)-19,20-Dihydroakuammicine, (±)-Norfluorocurarine, (±)-Echitamidine, and (±)-20-Epilochneridine1 , 1997 .
[54] K. Mae,et al. Control of extremely fast competitive consecutive reactions using micromixing. Selective Friedel-Crafts aminoalkylation. , 2005, Journal of the American Chemical Society.
[55] Takahide Fukuyama,et al. Spurring radical reactions of organic halides with tin hydride and TTMSS using microreactors. , 2008, Organic letters.
[56] J. Yoshida,et al. Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems , 2009, Beilstein journal of organic chemistry.