A Novel Visualization of DNA Sequences, Reflecting GC-Content

Significant progresses of visualization technology of DNA sequences have been made by solving visual effect problems of degeneracy, loss of information, difficulty in multidimensional space and difficulty for long DNA sequences. Different from traditional models focusing on visualization effect problems, we propose a novel visualization tool — GC-Curve, which not only solves all the visual effect problems mentioned above, but also can show the GC-content of a DNA. GC-content is an important feature of DNA, which is related to the stability of DNA, the density of genes, natural selection, mutational bias, etc. So the visualization reflecting GC-content has great potential in many applications. The applications of GC-Curve on similarity analysis, GC-content analysis, stability analysis and melting temperature prediction are presented. A software of GC-Curve is available at https://www.box.com/s/g872v3pq4kuz86sj5coq.

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