论文信息 - Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.

Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."

[1] Keiko Tanaka,et al. HLA A24 in paraneoplastic cerebellar degeneration with anti-Yo antibody , 1996, Neurology.

[2] A Sette,et al. Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs. , 1996, Immunology today.

[3] P. Parham,et al. Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes , 1995, Current Biology.

[4] J. Henson,et al. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal , 1991, Cell.

[5] E. Campo,et al. Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis , 1990, Neurology.