Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community‐Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial

To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community‐dwelling elderly sarcopenic women.

[1]  R. Wolfe,et al.  Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. , 2005, The American journal of clinical nutrition.

[2]  S B Roberts,et al.  Exercise training and nutritional supplementation for physical frailty in very elderly people. , 1994, The New England journal of medicine.

[3]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[4]  Jacob Cohen,et al.  A power primer. , 1992, Psychological bulletin.

[5]  M. Sheffield-Moore,et al.  Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. , 2008, Journal of applied physiology.

[6]  J. Baeyens,et al.  Sarcopenia: European consensus on definition and diagnosis , 2010, Age and ageing.

[7]  S B Heymsfield,et al.  Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. , 1998, Journal of applied physiology.

[8]  R. Ross,et al.  Estimation of skeletal muscle mass by bioelectrical impedance analysis. , 2000, Journal of applied physiology.

[9]  S. B. Wilkinson,et al.  Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. , 2007, The American journal of clinical nutrition.

[10]  Hideyo Yoshida,et al.  Randomized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japanese women , 2004, Journal of Bone and Mineral Metabolism.

[11]  A. Yashin,et al.  Body Mass Index and Nine‐Year Mortality in Disabled and Nondisabled Older U.S. Individuals , 2008, Journal of the American Geriatrics Society.

[12]  Y. Wu,et al.  Prevalence of Sarcopenia Estimated Using a Bioelectrical Impedance Analysis Prediction Equation in Community‐Dwelling Elderly People in Taiwan , 2008, Journal of the American Geriatrics Society.

[13]  Gerry Purdy,et al.  Summary comments , 1981, SIGB.

[14]  R. Baumgartner,et al.  Predictors of skeletal muscle mass in elderly men and women , 1999, Mechanisms of Ageing and Development.

[15]  R. Wolfe,et al.  A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. , 2006, American journal of physiology. Endocrinology and metabolism.

[16]  A. Kenny,et al.  Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[17]  R. Wolfe,et al.  Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein , 2006, Experimental Gerontology.

[18]  W. Evans.  What is sarcopenia? , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[20]  S. Heymsfield,et al.  Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods. , 1996, Journal of applied physiology.

[21]  S. Borst.  Interventions for sarcopenia and muscle weakness in older people. , 2004, Age and ageing.

[22]  D. Chinkes,et al.  Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. , 2009, The Journal of clinical endocrinology and metabolism.

[23]  Y. Yoshida,et al.  Effectiveness of Multidimensional Exercises for the Treatment of Stress Urinary Incontinence in Elderly Community‐Dwelling Japanese Women: A Randomized, Controlled, Crossover Trial , 2007, Journal of the American Geriatrics Society.

[24]  J. Fleg,et al.  Muscle Size Responses to Strength Training in Young and Older Men and Women , 2001, Journal of the American Geriatrics Society.

[25]  R. Ross,et al.  Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. , 2004, American journal of epidemiology.

[26]  Ananda Sen,et al.  Resistance exercise for muscular strength in older adults: A meta-analysis , 2010, Ageing Research Reviews.

[27]  G. Borg.  Psychophysical bases of perceived exertion. , 1982, Medicine and science in sports and exercise.

[28]  R. Baumgartner.  Body Composition in Healthy Aging , 2000, Annals of the New York Academy of Sciences.

[29]  L. Ellegård,et al.  Body composition in the elderly: reference values and bioelectrical impedance spectroscopy to predict total body skeletal muscle mass. , 2009, Clinical nutrition.

[30]  Amir Herman,et al.  Intention-to-treat analysis and accounting for missing data in orthopaedic randomized clinical trials. , 2009, Journal of Bone and Joint Surgery. American volume.

[31]  Nancy K Latham,et al.  Progressive resistance strength training for improving physical function in older adults. , 2009, The Cochrane database of systematic reviews.

[32]  W. Bortz.  Disuse and aging. , 1982, JAMA.

[33]  R. Wolfe,et al.  Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. , 2003, The American journal of clinical nutrition.

[34]  I. H. Rosenberg,et al.  Summary comments : Epidemiological and methodological problem in determining nutritional status of older persons , 1989 .

[35]  Tamara B Harris,et al.  Knee Extension Strength Cutpoints for Maintaining Mobility , 2007, Journal of the American Geriatrics Society.

[36]  R. Wolfe,et al.  Milk ingestion stimulates net muscle protein synthesis following resistance exercise. , 2006, Medicine and science in sports and exercise.