Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

[1]  K. Takeshita,et al.  A morphometric CT study of Down's syndrome showing small posterior fossa and calcification of basal ganglia , 2004, Neuroradiology.

[2]  H. Joost,et al.  Unusual function of the activation loop in the protein kinase DYRK1A. , 2003, Biochemical and biophysical research communications.

[3]  P. Cohen,et al.  The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. , 2001, The Biochemical journal.

[4]  T. Blundell,et al.  Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A. , 2001, The Biochemical journal.

[5]  Y. A. Minamishima,et al.  A possible role for centrosome overduplication in radiation-induced cell death , 2000, Oncogene.

[6]  N. Sato,et al.  Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells. , 2000, Experimental cell research.

[7]  R. van Driel,et al.  Cell cycle regulation of PML modification and ND10 composition. , 1999, Journal of cell science.

[8]  N. Shimizu,et al.  High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development. , 1999, Genomics.

[9]  W. Lingle,et al.  Altered centrosome structure is associated with abnormal mitoses in human breast tumors. , 1999, The American journal of pathology.

[10]  Y. Hiraoka,et al.  Multiple-color fluorescence imaging of chromosomes and microtubules in living cells. , 1999, Cell structure and function.

[11]  K. Guan,et al.  Negative Regulation of the Forkhead Transcription Factor FKHR by Akt* , 1999, The Journal of Biological Chemistry.

[12]  P. Cohen,et al.  Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence* , 1999, The Journal of Biological Chemistry.

[13]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[14]  X. Estivill,et al.  Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. , 1999, Biochemical and biophysical research communications.

[15]  B. L. Shapiro.  The Down syndrome critical region. , 1999, Journal of neural transmission. Supplementum.

[16]  H. Joost,et al.  Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases* , 1998, The Journal of Biological Chemistry.

[17]  N. Shimizu,et al.  Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts. , 1998, Biochemical and biophysical research communications.

[18]  H Knecht,et al.  Centrosome defects and genetic instability in malignant tumors. , 1998, Cancer research.

[19]  B. Nelms,et al.  hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks , 1997, Molecular and cellular biology.

[20]  Edward M. Rubin,et al.  Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice. , 1997, Human molecular genetics.

[21]  Ralph Scully,et al.  Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage , 1997, Cell.

[22]  T. Sternsdorf,et al.  Cellular Localization, Expression, and Structure of the Nuclear Dot Protein 52 , 1997, The Journal of cell biology.

[23]  Y. Hiraoka,et al.  Dynamics of chromosomes and microtubules visualized by multiple‐wavelength fluorescence imaging in living mammalian cells: effects of mitotic inhibitors on cell cycle progression , 1997, Genes to cells : devoted to molecular & cellular mechanisms.

[24]  Jan-Fang Cheng,et al.  Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome , 1997, Nature Genetics.

[25]  N. Shimizu,et al.  Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. , 1996, Biochemical and biophysical research communications.

[26]  A. Schürmann,et al.  Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII (*) , 1996, The Journal of Biological Chemistry.

[27]  R. Zinkowski,et al.  Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells , 1995, The Journal of cell biology.

[28]  M Heisenberg,et al.  minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila , 1995, Neuron.

[29]  C. Disteche,et al.  Down syndrome phenotypes: the consequences of chromosomal imbalance. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[30]  B. Alberts,et al.  The centrosome and cellular organization. , 1994, Annual review of biochemistry.

[31]  S. Biggins,et al.  Unravelling the tangled web at the microtubule-organizing center. , 1993, Current opinion in cell biology.

[32]  J. Delabar,et al.  Molecular Mapping of Twenty-Four Features of Down Syndrome on Chromosome 21 , 1993, European journal of human genetics : EJHG.

[33]  T. Maniatis,et al.  Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus , 1990, Nature.

[34]  A. Aurias,et al.  Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[35]  E. Hook.  The consequences of chromosome imbalance: Principles, mechanisms, and models , 1987 .

[36]  C. Epstein.  The Consequences of Chromosome Imbalance: The Consequences of Chromosome Imbalance , 1986 .