Immunogenicity of monococcum wheat in celiac patients 1 – 4

Background: Research is intense to find wheat of low or null toxicity for patients with celiac disease (CD). Among candidates, there are diploid wheat species. Objective: We compared the immunological properties of 2 lines of diploid monococcum wheat (Triticum monococcum ssp. monococcum), Monlis and ID331, with those of common wheat (Triticum

[1]  A. Camarca,et al.  Repertoire of gluten peptides active in celiac disease patients: perspectives for translational therapeutic applications. , 2012, Endocrine, metabolic & immune disorders drug targets.

[2]  F. Koning,et al.  Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules , 2012, Immunogenetics.

[3]  M. Barone,et al.  Immunogenicity of two oat varieties, in relation to their safety for celiac patients , 2011, Scandinavian journal of gastroenterology.

[4]  M. Barone,et al.  Gliadin-Mediated Proliferation and Innate Immune Activation in Celiac Disease Are Due to Alterations in Vesicular Trafficking , 2011, PloS one.

[5]  J. Drijfhout,et al.  A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease , 2010, PloS one.

[6]  L. Sollid,et al.  Tissue-mediated control of immunopathology in coeliac disease , 2009, Nature Reviews Immunology.

[7]  J. Sidney,et al.  Intestinal T Cell Responses to Gluten Peptides Are Largely Heterogeneous: Implications for a Peptide-Based Therapy in Celiac Disease1 , 2009, The Journal of Immunology.

[8]  A. Sette,et al.  Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis. , 2008, Gastroenterology.

[9]  L. Gazza,et al.  Environmental factors of celiac disease: Cytotoxicity of hulled wheat species Triticum monococcum, T. turgidum ssp. dicoccum and T. aestivum ssp. spelta , 2007, Journal of gastroenterology and hepatology.

[10]  Paolo Bergamo,et al.  Transamidation of wheat flour inhibits the response to gliadin of intestinal T cells in celiac disease. , 2007, Gastroenterology.

[11]  M. Barone,et al.  Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease , 2006, Gut.

[12]  A. Buda,et al.  Lack of intestinal mucosal toxicity of Triticum monococcum in celiac disease patients , 2006, Scandinavian journal of gastroenterology.

[13]  J. Drijfhout,et al.  Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. , 2005, Gastroenterology.

[14]  M. Ráki,et al.  Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. , 2005, Gastroenterology.

[15]  Seiamak Bahram,et al.  A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. , 2004, Immunity.

[16]  Govind Bhagat,et al.  Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. , 2004, Immunity.

[17]  V. Raia,et al.  Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease , 2003, The Lancet.

[18]  S Auricchio,et al.  An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients , 2003, Gut.

[19]  L. Sollid Coeliac disease: dissecting a complex inflammatory disorder , 2002, Nature Reviews Immunology.

[20]  G. Oberhuber,et al.  The histopathology of coeliac disease: time for a standardized report scheme for pathologists. , 1999, European journal of gastroenterology & hepatology.

[21]  K. Lundin,et al.  Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. , 1998, Gastroenterology.

[22]  L. Fugger,et al.  Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease , 1998, Nature Medicine.

[23]  R. Luchetti,et al.  In vitro toxicity testing of alcohol-soluble proteins from diploid wheat Triticum monococcum in celiac disease. , 1996, Journal of Biochemical Toxicology.

[24]  V. Silano,et al.  Toxicity of Wheat Flour Proteins and Protein-Derived Peptides for In Vitro Developing Intestine from Rat Fetus , 1979, Pediatric Research.