Mechanical Circulatory Support Device Database of the International Society for Heart and Lung Transplantation

Over the last 2 decades, mechanical circulatory support devices have been developed at a rapid pace with the goal of supporting patients with advanced heart failure as a bridge to cardiac transplantation, a bridge to recovery, and an alternative to transplantation, also called chronic or destination therapy. The current generation of devices provides a differentiated spectrum of circulatory support. The major limitations are infection, coagulopathies, and device dysfunction. The Scientific Council on Mechanical Circulatory Support of the International Society for Heart and Lung Transplantation has established an international database (http://www.ishlt.org/regist_mcsd_main.htm) to generate critical data to advance knowledge about effectiveness of mechanical circulatory support device therapy for one of the most difficult and costly contemporary medical problems, the malignant syndrome of advanced heart failure.

[1]  O. Frazier Mechanical circulatory support: new advances, new pumps, new ideas. , 2002, Seminars in thoracic and cardiovascular surgery.

[2]  M. Oz,et al.  Comparison of exercise performance in patients with chronic severe heart failure versus left ventricular assist devices. , 1998, Circulation.

[3]  B. Griffith,et al.  Mechanical cardiac support 2000: current applications and future trial design. June 15-16, 2000 Bethesda, Maryland. , 2001, Journal of the American College of Cardiology.

[4]  Robert L. Kormos,et al.  Mechanical Circulatory Support device database of the International Society for Heart and Lung Transplantation: first annual report--2003. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[5]  R Hetzer,et al.  Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. , 1997, Circulation.

[6]  Silviu Itescu,et al.  Activation-induced T-cell death and immune dysfunction after implantation of left-ventricular assist de vice , 1999, The Lancet.

[7]  Daniel Levy,et al.  Long-term trends in the incidence of and survival with heart failure. , 2002, The New England journal of medicine.

[8]  A. Nicholson,et al.  Adjunctive use of inhaled nitric oxide during implantation of a left ventricular assist device. , 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[9]  P M Portner,et al.  Improved outcomes with an implantable left ventricular assist system: a multicenter study. , 2001, The Annals of thoracic surgery.

[10]  J. Kirklin,et al.  Cardiac transplant outcome of patients supported on left ventricular assist device vs. intravenous inotropic therapy. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[11]  M. Redfield,et al.  Heart failure--an epidemic of uncertain proportions. , 2002, The New England journal of medicine.

[12]  W. Pae,et al.  Combined registry for the clinical use of mechanical ventricular assist pumps and the total artificial heart. , 1986, The Journal of heart transplantation.

[13]  S. Hunt A fair way of donating hearts for transplantation , 2000, BMJ : British Medical Journal.

[14]  H. Scheld,et al.  Effect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity , 2000, BMJ : British Medical Journal.

[15]  M C Oz,et al.  Long-term use of a left ventricular assist device for end-stage heart failure. , 2001, The New England journal of medicine.

[16]  W. Pae,et al.  Database: relevant or not. , 2001, The Annals of thoracic surgery.

[17]  L. Stevenson,et al.  Mechanical Cardiac Support 2000: Current applications and future trial design. , 2001, The Journal of thoracic and cardiovascular surgery.

[18]  R. Benza,et al.  Treatment of end-stage heart disease with outpatient ventricular assist devices. , 2002, The Annals of thoracic surgery.

[19]  James B. Young,et al.  Proposition: the benefit of cardiac transplantation in stable outpatients with heart failure should be tested in a randomized trial. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[20]  E. Trulock,et al.  The registry of the international society for heart and lung transplantation: nineteenth official report-2002. , 2002, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[21]  P M Portner,et al.  Mechanical Circulatory Support for Advanced Heart Failure: Effect of Patient Selection on Outcome , 2001, Circulation.