Leukocyte-Related Disorders: A Review for the Pediatrician.

Leukocytes, or white blood cells, are part of the innate immune system that defends against infectious and foreign agents. In pediatrics, it is important to use age-specific laboratory values when interpreting results. Infections are the most common cause of leukocytosis or leukopenia in children. Symptoms suggestive of more serious etiologies include persistent fevers, weight loss, bruising, fatigue, and adenopathy. Neutropenia is of special importance in pediatrics due to associations of severe neutropenia with genetic syndromes and overlapping presentations with primary immunodeficiencies. Although the discovery of novel genetic mutations has aided the hematologist/oncologist and the immunologist in managing these conditions, the relationship between clinical phenotype and mutation is still not well known. [Pediatr Ann. 2020;49(1):e17-e26.].

[1]  T. George,et al.  Leukocytosis , 2014, International journal of laboratory hematology.

[2]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps Kill Bacteria , 2004, Science.

[3]  O. Eden,et al.  Autoimmune neutropenia of infancy. , 1992, Journal of clinical pathology.

[4]  Philip S Rosenberg,et al.  The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. , 2005, Blood.

[5]  A. Nagler,et al.  Granulocyte colony-stimulating factor generates epigenetic and genetic alterations in lymphocytes of normal volunteer donors of stem cells. , 2004, Experimental hematology.

[6]  J. Halterman,et al.  Neutropenia in pediatric practice. , 2008, Pediatrics in review.

[7]  C. Bellanné-Chantelot,et al.  Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history , 2017, British journal of haematology.

[8]  Philip S Rosenberg,et al.  Stable long‐term risk of leukaemia in patients with severe congenital neutropenia maintained on G‐CSF therapy , 2010, British journal of haematology.

[9]  G. Rodgers,et al.  Natural history of benign ethnic neutropenia in individuals of African ancestry. , 2019, Blood cells, molecules & diseases.

[10]  Jedda Rupert,et al.  Evaluation of Patients with Leukocytosis. , 2015, American family physician.

[11]  Christopher A. Miller,et al.  Somatic mutations and clonal hematopoiesis in congenital neutropenia. , 2018, Blood.

[12]  F. Newell.  Standard Values in Blood , 1952 .

[13]  R. Schleimer,et al.  The effects of glucocorticoids on human eosinophils. , 1994, The Journal of allergy and clinical immunology.

[14]  M. Rothenberg,et al.  The eosinophil. , 2006, Annual review of immunology.

[15]  K. Walkovich,et al.  Congenital Neutropenia and Rare Functional Phagocyte Disorders in Children. , 2019, Hematology/oncology clinics of North America.

[16]  P. Newburger,et al.  A molecular classification of congenital neutropenia syndromes , 2007, Pediatric blood & cancer.

[17]  L. Boxer.  Neutrophil abnormalities. , 2003, Pediatrics in review.

[18]  L. Boxer,et al.  How to approach neutropenia in childhood. , 2013, Pediatrics in review.

[19]  D. Dale.  How I manage children with neutropenia , 2017, British journal of haematology.

[20]  Richard B. Johnston,et al.  Chronic Granulomatous Disease: Report on a National Registry of 368 Patients , 2000, Medicine.