Cartilage thickness in the hip joint measured by MRI and stereology--a methodological study.

OBJECTIVE The purpose of this study was to develop a precise and efficient method for estimating the thickness of the articular cartilage in the hip joint and hence three different stereologic methods were tested based on Magnetic Resonance Imaging. DESIGN Twenty two females and four males with hip dysplasia underwent MRI. The thickness of the femoral and acetabular cartilage was estimated. RESULTS The results for all three methods showed that the observed total variance on cartilage thickness is small. The mean thickness of the acetabular cartilage measured by the three different methods ranged between 1.15 mm and 1.46 mm. The mean thickness for the femoral cartilage measured by the three different methods ranged between 1.18 mm and 1.78 mm. The measurements took 15-20 min per hip to carry out. CONCLUSION Methods 1 and 3 are as precise but we favour method 3 because the measurements are done on images obtained through the center of the femoral head which means that the cartilage surface is intersected perpendicular and partial volume effect avoided. We suggest that this method can be advantageous for assessing the progression of osteoarthritis in dysplastic hips after periacetabular osteotomy.

[1]  C. McGibbon,et al.  Subchondral bone and cartilage thickness from MRI: effects of chemical-shift artifact , 2003, Magnetic Resonance Materials in Physics, Biology and Medicine.

[2]  N. Sugano,et al.  Articular Cartilage Abnormalities in Dysplastic Hips Without Joint Space Narrowing , 2001, Clinical orthopaedics and related research.

[3]  F Eckstein,et al.  Magnetic resonance chondro‐crassometry (MR CCM): A method for accurate determination of articular cartilace thickness? , 1996, Magnetic resonance in medicine.

[4]  G. Wiberg,et al.  Studies on dysplastic acetabula and congenital subluxation of the hip joint : with special reference to the complication of osteoarthritis , 1939 .

[5]  T. Kubo,et al.  Radial MRI of the hip with moderate osteoarthritis. , 2000, The Journal of bone and joint surgery. British volume.

[6]  T. Nishii,et al.  MR evaluation of the articular cartilage of the femoral head during traction. Correlation with resected femoral head. , 1999, Acta radiologica.

[7]  R. Østerby,et al.  Distribution of Membrane Thickness Determined By Lineal Analysis , 1978, Journal of microscopy.

[8]  S. Coleman,et al.  Congenital dysplasia and dislocation of the hip. , 1973, JAMA.

[9]  Kjeld Søballe,et al.  Changes in load-bearing area after Ganz periacetabular osteotomy evaluated by multislice CT scanning and stereology , 2004, Acta orthopaedica Scandinavica.

[10]  E. B. Jensen,et al.  Determination of membrane thickness distribution from orthogonal intercepts , 1979, Journal of microscopy.

[11]  H. Gundersen,et al.  The efficiency of systematic sampling in stereology — reconsidered , 1999, Journal of microscopy.

[12]  T Nishii,et al.  Articular cartilage evaluation in osteoarthritis of the hip with MR imaging under continuous leg traction. , 1998, Magnetic resonance imaging.

[13]  Masahiro Yoshida,et al.  Subchondral Cysts Arise in the Anterior Acetabulum in Dysplastic Osteoarthritic Hips , 2002, Clinical orthopaedics and related research.

[14]  Hironobu Nakamura,et al.  MR Evaluation of the Articular Cartilage of the Femoral Head during Traction , 1999 .

[15]  H. Iwata,et al.  Magnetic resonance imaging in osteoarthrosis of the dysplastic hip , 2004, Archives of Orthopaedic and Trauma Surgery.

[16]  Hideki Yoshikawa,et al.  Three-dimensional distribution of acetabular cartilage thickness in patients with hip dysplasia: a fully automated computational analysis of MR imaging. , 2004, Osteoarthritis and cartilage.

[17]  J. Mast,et al.  The periacetabular osteotomy. Minimum 2 year followup in more than 100 hips. , 1999, Clinical orthopaedics and related research.

[18]  D Resnick,et al.  Width of the articular cartilage of the hip: quantification by using fat-suppression spin-echo MR imaging in cadavers. , 1992, AJR. American journal of roentgenology.

[19]  A. Iglič,et al.  Mathematical estimation of stress distribution in normal and dysplastic human hips , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[20]  J R Nyengaard,et al.  Stereologic methods and their application in kidney research. , 1999, Journal of the American Society of Nephrology : JASN.

[21]  K. Søballe Guest editorial - Pelvic osteotomy for acetabular dysplasia , 2003, Acta orthopaedica Scandinavica.

[22]  K. Søballe,et al.  The relationship of hip joint space to self reported hip pain. A survey of 4.151 subjects of the Copenhagen City Heart Study: the Osteoarthritis Substudy. , 2004, Osteoarthritis and cartilage.

[23]  Y. Iwamoto,et al.  Cartilage and labrum degeneration in the dysplastic hip generally originates in the anterosuperior weight-bearing area: an arthroscopic observation. , 1999, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[24]  C A McGibbon,et al.  A general computing method for spatial cartilage thickness from co-planar MRI. , 1998, Medical engineering & physics.

[25]  Miroslav Sochor,et al.  Gradient of contact stress in normal and dysplastic human hips. , 2003, Medical engineering & physics.

[26]  Michael D Maloney,et al.  Articular Cartilage Biology , 2003, The Journal of the American Academy of Orthopaedic Surgeons.