Design of a light stimulator for fetal and neonatal magnetoencephalography

The design, safety analysis and performance of a fetal visual stimulation system suitable for fetal and neonatal magnetoencephalography studies are presented. The issue of fetal, neonatal and maternal safety is considered and the maximum permissible exposure is computed for the maternal skin and the adult eye. The risk for neonatal eye exposure is examined. It is demonstrated that the fetus, neonate and mother are not at risk.

[1]  I Lavery,et al.  Safe use of lasers. , 1978, Occupational health; a journal for occupational health nurses.

[2]  E. Saling,et al.  First magnetoencephalographic recordings of the brain activity of a human fetus , 1985, British journal of obstetrics and gynaecology.

[3]  H. Preissl,et al.  Fetal magnetoencephalography: viewing the developing brain in utero. , 2005, International review of neurobiology.

[4]  J. Weiter,et al.  Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. , 1986, Investigative ophthalmology & visual science.

[5]  H Eswaran,et al.  Validation of the flash-evoked response from fetal MEG , 2007, Physics in medicine and biology.

[6]  Hubert Preissl,et al.  Fetal magnetoencephalography--a multimodal approach. , 2005, Brain research. Developmental brain research.

[7]  Naoki Nagata,et al.  The relationship between the response to external light stimulation and behavioral states in the human fetus: how it differs from vibroacoustic stimulation. , 2000, Early human development.

[8]  John Mellerio,et al.  WHAT IS THE MEANING OF THRESHOLD IN LASER INJURY EXPERIMENTS? IMPLICATIONS FOR HUMAN EXPOSURE LIMITS , 2002, Health physics.

[9]  Fred P. Seeber,et al.  OP-TEC national center for optics and photonics education and ANSI Z136.5 American National Standard for the safe use of lasers in educational institutions – How they will work together to improve laser safety in educational institutions , 2009 .

[10]  F. Harlen,et al.  Biological bases of maximum permissible exposure levels of laser standards. II. Comparison of threshold injury data with maximum permissible exposure levels , 1984 .

[11]  S. Hecht,et al.  ENERGY, QUANTA, AND VISION , 1942, The Journal of general physiology.

[12]  Stephen E. Robinson,et al.  SQUID sensor array configurations for magnetoencephalography applications , 2002 .

[13]  A. Fielder,et al.  Environmental light and the preterm infant. , 2000, Seminars in perinatology.

[14]  M. Belkin,et al.  Laser eye injuries. , 2000, Survey of ophthalmology.

[15]  A. Fielder,et al.  The immature visual system and premature birth. , 1988, British medical bulletin.

[16]  D. Norren,et al.  Optical density of the aging human ocular media in the visible and the UV , 2007 .

[17]  A R Fielder,et al.  Pupillary diameter and reaction to light in preterm neonates. , 1990, Archives of disease in childhood.

[18]  H. Preissl,et al.  Magnetoencephalographic recordings of visual evoked brain activity in the human fetus , 2002, The Lancet.

[19]  P. Hardy,et al.  Control of cerebral and ocular blood flow autoregulation in neonates. , 1997, Pediatric clinics of North America.

[20]  Vladimir P. Zharov,et al.  Deep penetration of light into biotissue , 2001, SPIE BiOS.

[21]  D. H. Sliney.  Risk assessment and laser safety , 1995 .

[22]  R. Hamilton,et al.  Ocular biometry in preterm infants: implications for estimation of retinal illuminance. , 2008, Investigative ophthalmology & visual science.

[23]  W. Polishuk,et al.  [Fetal reaction to external light]. , 1975, Harefuah.

[24]  William T. Ham,et al.  An equilibrium thermal model for retinal injury from optical sources. , 1969, Applied optics.

[25]  D. Sliney,et al.  Safety with Lasers and Other Optical Sources , 1980, Springer US.

[26]  A. N. Takata,et al.  Thermal Model of Laser-Induced Eye Damage , 1974 .

[27]  D. Peleg,et al.  Fetal heart rate acceleration in response to light stimulation as a clinical measure of fetal well-being. A preliminary report. , 1980, Journal of perinatal medicine.

[28]  D. Baylor,et al.  Responses of retinal rods to single photons. , 1979, The Journal of physiology.

[29]  J D Wilson,et al.  Challenges of recording human fetal auditory-evoked response using magnetoencephalography. , 2000, The Journal of maternal-fetal medicine.

[30]  A. Welch,et al.  The thermal response of laser irradiated tissue , 1984, IEEE Journal of Quantum Electronics.

[31]  Hubert Preissl,et al.  Functional development of the visual system in human fetus using magnetoencephalography , 2004, Experimental Neurology.