The Path to Perdition Is Paved with Protons

Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation.

[1]  Wolfgang Wintermeyer,et al.  Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. , 2002, Molecular cell.

[2]  S. Nakano,et al.  General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme. , 2000, Science.

[3]  T. Steitz,et al.  The structural basis of ribosome activity in peptide bond synthesis. , 2000, Science.

[4]  M Yarus,et al.  An inhibitor of ribosomal peptidyl transferase using transition-state analogy. , 1995, Biochemistry.

[5]  T. Steitz,et al.  A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits , 2002, Nature Structural Biology.

[6]  Schmidt De,et al.  PK of the lysine amino group at the active site of acetoacetate decarboxylase. , 1971 .

[7]  S. Dorner,et al.  A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. Knowles,et al.  The intrinsic pKa-values of functional groups in enzymes: improper deductions from the pH-dependence of steady-state parameters. , 1976, CRC critical reviews in biochemistry.

[9]  S. Dorner,et al.  Mechanism of ribosomal peptide bond formation. , 2001, Science.

[10]  I. Tinoco,et al.  Solution structure of loop A from the hairpin ribozyme from tobacco ringspot virus satellite. , 1996, Biochemistry.

[11]  Thomas A Steitz,et al.  Structural insights into peptide bond formation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  T. Steitz,et al.  The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. , 2000, Science.

[13]  A. Zamir,et al.  The inactivation and reactivation of ribosomal-peptidyl transferase of E. coli. , 1968, Biochemical and biophysical research communications.

[14]  A. Rich,et al.  Ribosome-catalyzed ester formation. , 1970, Biochemistry.

[15]  S. Strobel,et al.  A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center. , 2000, Science.

[16]  B. Maden,et al.  Ribosome‐Catalyzed Peptidyl Transfer , 1968 .

[17]  K. Parnell,et al.  Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[18]  W. Jencks.  Catalysis in chemistry and enzymology , 1969 .

[19]  W. Jencks,et al.  The mechanism of the aminolysis of acetate esters. , 1974, Journal of the American Chemical Society.

[20]  H. Noller,et al.  Ribosomes and translation. , 1997, Annual review of biochemistry.