Venous thromboembolism during pregnancy and postpartum: study in a tertiary hospital

Objective To examine whether implementing an evidence based guideline reduces the risk of symptomatic Venous Thrombo Embolism VTE during pregnancy and up to months postpartum Methods This was a hospital based retrospective cohort study of deliveries over a year period at Nara Medical University Hospital Japan We compared the incidence of symptomatic VTE before and after the introduction of the Japanese thrombo prophylaxis guideline and analyzed the medical records of pregnant women admitted to this hospital Result The overall incidence of symptomatic VTE among the study subjects was deliveries representing an incidence of Deep Venous Thrombosis DVT and Pulmonary Thrombo Embolism PTE of and respectively During the pregnancy and postpartum periods and VTE cases respectively were observed The risk of DVT was possibly the highest in the first trimester All the objectively confirmed PTEs typically presented postpartum or within days of delivery Further of VTE cases had one or more large anamnestic risk factor s The effect was small but the incidence of VTE vs decreased by during the post implementation period Conclusion VTE cases may at least be partially prevented using the clinical practice guideline

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