Toxins in Drug Discovery and Pharmacology

Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as a new emerging source of peptide-based therapeutics.

[1]  A. V. Lobanov,et al.  Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant , 2018, Toxins.

[2]  J. Tytgat,et al.  The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels , 2018, Toxins.

[3]  Hyo-Jin An,et al.  Bee Venom Suppresses the Differentiation of Preadipocytes and High Fat Diet-Induced Obesity by Inhibiting Adipogenesis , 2017, Toxins.

[4]  Bingmiao Gao,et al.  Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery , 2017, Toxins.

[5]  R. Araya-Maturana,et al.  Targeting Metastasis with Snake Toxins: Molecular Mechanisms , 2017, Toxins.

[6]  N. Matoba,et al.  Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa , 2017, Toxins.

[7]  Shunyi Zhu,et al.  Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs , 2017, Toxins.

[8]  F. Quan,et al.  Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α2-Adrenergic Receptor , 2017, Toxins.

[9]  Michal Linial,et al.  Overlooked Short Toxin-Like Proteins: A Shortcut to Drug Design , 2017, Toxins.

[10]  Kwan-Kyu Park,et al.  The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts , 2017, Toxins.

[11]  T. Nguyễn,et al.  Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom , 2017, Toxins.

[12]  K. Kuča,et al.  Can Inhibitors of Snake Venom Phospholipases A2 Lead to New Insights into Anti-Inflammatory Therapy in Humans? A Theoretical Study , 2017, Toxins.

[13]  W. Bang,et al.  Anti-Salmonella Activity Modulation of Mastoparan V1—A Wasp Venom Toxin—Using Protease Inhibitors, and Its Efficient Production via an Escherichia coli Secretion System , 2017, Toxins.

[14]  A. Priel,et al.  Animal Toxins Providing Insights into TRPV1 Activation Mechanism , 2017, Toxins.

[15]  M. Majewski,et al.  The Influence of Resiniferatoxin (RTX) and Tetrodotoxin (TTX) on the Distribution, Relative Frequency, and Chemical Coding of Noradrenergic and Cholinergic Nerve Fibers Supplying the Porcine Urinary Bladder Wall , 2017, Toxins.

[16]  E. L. Ryzhkovskaya,et al.  Cobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom , 2017, Toxins.

[17]  Jung-Hyun Choi,et al.  Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I) , 2017, Toxins.

[18]  Yunhai Yi,et al.  High Throughput Identification of Antimicrobial Peptides from Fish Gastrointestinal Microbiota , 2017, Toxins.

[19]  Junghyun Park,et al.  Botulinum Toxin for the Treatment of Neuropathic Pain , 2017, Toxins.

[20]  D. Craik,et al.  Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins , 2017, Toxins.

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[22]  A. Harvey,et al.  Toxins and drug discovery. , 2014, Toxicon : official journal of the International Society on Toxinology.

[23]  S. Serrano,et al.  Bradykinin-potentiating peptides: beyond captopril. , 2012, Toxicon : official journal of the International Society on Toxinology.

[24]  J. Egan,et al.  Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness , 1997, Molecular and Cellular Endocrinology.

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[26]  J. Raufman,et al.  Exendin-4, a new peptide from Heloderma suspectum venom, potentiates cholecystokinin-induced amylase release from rat pancreatic acini , 1992, Regulatory Peptides.