Efficacy of venous reconstruction in patients with adenocarcinoma of the pancreatic head

Pancreaticoduodenectomy is often avoided in patients with portal or superior mesenteric venous involvement due to the perception that venous resection is complex, morbid, and carries a poor longterm survival. Our recent experience using state-of-the-art imaging and strict resection criteria show that venous reconstruction increases operative time, transfusion requirements, intensive care unit stay, and total hospital length of stay, but has no significant impact on operative morbidity rates, mortality rates, or the incidence of positive histologic margins. Kalpan-Meier life table analysis shows similar survival curves when compared to a contemporary cohort of patients who do not undergo venous reconstruction.

[1]  T. Colby,et al.  Long‐Term Survival After Resection for Ductal Adenocarcinoma of the Pancreas Is It Really Improving? , 1995, Annals of surgery.

[2]  C. Charnsangavej,et al.  Survival following pancreaticoduodenectomy with resection of the superior mesenteric–portal vein confluence for adenocarcinoma of the pancreatic head , 1998, The British journal of surgery.

[3]  Alicia Samuels,et al.  Cancer Statistics, 2003 , 2003, CA: a cancer journal for clinicians.

[4]  T. Nagakawa,et al.  Surgical strategy for carcinoma of the pancreas head area based on clinicopathologic analysis of nodal involvement and plexus invasion. , 1995, Surgery.

[5]  S. Nomoto,et al.  The role of extended radical operation for pancreatic cancer. , 2001, Hepato-gastroenterology.

[6]  K. Dhaene,et al.  Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. , 1998, Annals of surgery.

[7]  M. Schäfer,et al.  Evidence-Based Pancreatic Head Resection for Pancreatic Cancer and Chronic Pancreatitis , 2002, Annals of surgery.

[8]  I. Miyazaki,et al.  Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus , 1991, International journal of pancreatology : official journal of the International Association of Pancreatology.

[9]  T. Nagakawa,et al.  Extended radical pancreatectomy for carcinoma of the head of the pancreas. , 1998, Hepato-gastroenterology.

[10]  M. Brennan,et al.  Portal vein involvement in pancreatic cancer: a sign of unresectability? , 1997, Advances in surgery.

[11]  K. Boudjema,et al.  Is pancreaticoduodenectomy with mesentericoportal venous resection safe and worthwhile? , 2001, American journal of surgery.

[12]  Cameron Jl,et al.  The current status of the Whipple operation for periampullary carcinoma. , 1992 .

[13]  D. Gouma,et al.  Segmental resection and wedge excision of the portal or superior mesenteric vein during pancreatoduodenectomy. , 2001, Surgery.

[14]  J. Cameron,et al.  The current status of the Whipple operation for periampullary carcinoma. , 1992, Advances in Surgery.

[15]  Traverso Lw,et al.  Preservation of the pylorus in pancreaticoduodenectomy. , 1978 .

[16]  J. Fortner Regional Pancreatectomy for Cancer of the Pancreas, Ampulla, and Other Related Sites: Tumor Staging and Results , 1984, Annals of surgery.

[17]  W. Sindelar Clinical experience with regional pancreatectomy for adenocarcinoma of the pancreas. , 1989, Archives of surgery.

[18]  R. Pichlmayr,et al.  Surgery for exocrine pancreatic cancer--who are the 5- and 10-year survivors? , 1995, Oncology.

[19]  K. Lillemoe,et al.  Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. , 1999, Annals of surgery.

[20]  C. Kuroda,et al.  Preoperative Indications for Extended Pancreatectomy for Locally Advanced Pancreas Cancer Involving the Portal Vein , 1992, Annals of surgery.

[21]  W. Longmire,et al.  Preservation of the pylorus in pancreaticoduodenectomy. , 1978, Surgery, gynecology & obstetrics.