Minimizing lipid signal bleed in brain 1H chemical shift imaging by post‐acquisition grid shifting

Low spatial resolution in conventional 1H brain chemical shifting imaging (CSI) studies causes partial volume error (PVE) or signal “bleed” that is especially deleterious to voxels near the scalp. The standard spatial apodization approach adversely affects spatial resolution. Here, a novel automated post‐processing strategy of partial volume correction employing grid shifting (“PANGS”) is presented, which minimizes residual PVE without compromising spatial resolution.

[1]  KLAUS-DIETMARMERFSOLDT Jensfrahm.  Localized Proton Spectroscopy Using Stimulated Echoes , 2004 .

[2]  P. Bottomley.  Spatial Localization in NMR Spectroscopy in Vivo , 1987, Annals of the New York Academy of Sciences.

[3]  Andreas Ebel,et al.  Comparison of inversion recovery preparation schemes for lipid suppression in 1H MRSI of human brain , 2003, Magnetic resonance in medicine.

[4]  C. Hardy,et al.  Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. , 1990, The New England journal of medicine.

[5]  V. L. Doyle,et al.  Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy , 2003, Magnetic resonance in medicine.

[6]  T. Mareci,et al.  Selective fourier transform localization , 1987, Magnetic resonance in medicine.

[7]  Joseph V. Hajnal,et al.  High Signal Regions in Normal White Matter Shown by Heavily T2‐Weighted CSF Nulled IR Sequences , 1992, Journal of computer assisted tomography.

[8]  X Hu,et al.  A new strategy for spectroscopic imaging. , 1994, Journal of magnetic resonance. Series B.

[9]  Ronald Ouwerkerk,et al.  Dual‐band water and lipid suppression for MR spectroscopic imaging at 3 Tesla , 2010, Magnetic resonance in medicine.

[10]  Wilson Fong.  Handbook of MRI Pulse Sequences , 2005 .

[11]  P. Carroll,et al.  Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging--clinicopathologic study. , 1999, Radiology.

[12]  G T Gullberg,et al.  Gibbs artifact removal in magnetic resonance imaging. , 1987, Medical physics.

[13]  N. Schuff,et al.  Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation , 1996, Magnetic resonance in medicine.

[14]  J. Kurhanewicz,et al.  Improved water and lipid suppression for 3D PRESS CSI using rf band selective inversion with gradient dephasing (basing) , 1997, Magnetic resonance in medicine.

[15]  Paul A Bottomley,et al.  Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. , 2013, Journal of magnetic resonance.

[16]  T. Foster,et al.  A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.

[17]  Xavier Golay,et al.  Simultaneous water and lipid suppression for in vivo brain spectroscopy in humans , 2005, Magnetic resonance in medicine.

[18]  Joseph V. Hajnal,et al.  Use of Fluid Attenuated Inversion Recovery (FLAIR) Pulse Sequences in MRI of the Brain , 1992, Journal of computer assisted tomography.

[19]  Michael Schär,et al.  Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. , 2012, Journal of magnetic resonance.

[20]  Michael Garwood,et al.  Solvent Suppression Using Selective Echo Dephasing , 1996 .

[21]  Paul A Bottomley,et al.  Quantifying in vivo MR spectra with circles. , 2006, Journal of magnetic resonance.

[22]  R. Lenkinski,et al.  Human breast lesions: characterization with proton MR spectroscopy. , 1998, Radiology.

[23]  Paul Strauss,et al.  Magnetic Resonance Imaging Physical Principles And Sequence Design , 2016 .

[24]  K. Miller.  On the Inverse of the Sum of Matrices , 1981 .

[25]  M. J. D. Powell,et al.  A fast algorithm for nonlinearly constrained optimization calculations , 1978 .

[26]  Jullie W Pan,et al.  RF shimming for spectroscopic localization in the human brain at 7 T , 2010, Magnetic resonance in medicine.

[27]  Paul A. Bottomley,et al.  NMR Spectroscopy of the Human Heart , 2009 .

[28]  B. Gagoski,et al.  Lipid suppression in CSI with spatial priors and highly undersampled peripheral k‐space , 2012, Magnetic resonance in medicine.

[29]  R. Gruetter,et al.  In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time , 1999, Magnetic resonance in medicine.

[30]  J. Mugler,et al.  Three‐dimensional magnetization‐prepared rapid gradient‐echo imaging (3D MP RAGE) , 1990, Magnetic resonance in medicine.

[31]  G M Bydder,et al.  MR Imaging: Clinical Use of the Inversion Recovery Sequence , 1985, Journal of computer assisted tomography.

[32]  Daniel M Spielman,et al.  B1 and T1 insensitive water and lipid suppression using optimized multiple frequency‐selective preparation pulses for whole‐brain 1H spectroscopic imaging at 3T , 2009, Magnetic resonance in medicine.

[33]  P. Roemer,et al.  The NMR phased array , 1990, Magnetic resonance in medicine.

[34]  P. Barker,et al.  In vivo proton MR spectroscopy of the human brain , 2006 .

[35]  J H Duyn,et al.  Multisection proton MR spectroscopic imaging of the brain. , 1993, Radiology.

[36]  John S. Leigh,et al.  Errors of fourier chemical-shift imaging and their corrections , 1991 .

[37]  K. Uğurbil,et al.  NMR chemical shift imaging in three dimensions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. J. D. Powell,et al.  THE CONVERGENCE OF VARIABLE METRIC METHODS FOR NONLINEARLY CONSTRAINED OPTIMIZATION CALCULATIONS , 1978 .

[39]  J. Kurhanewicz,et al.  Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer , 2000, Magnetic resonance in medicine.

[40]  L DelaBarre,et al.  BISTRO: An outer‐volume suppression method that tolerates RF field inhomogeneity , 2001, Magnetic resonance in medicine.

[41]  P. Boesiger,et al.  SENSE: Sensitivity encoding for fast MRI , 1999, Magnetic resonance in medicine.

[42]  Andrew A. Maudsley,et al.  Sensitivity in fourier imaging , 1986 .

[43]  S. Nelson.  Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors , 2001, Magnetic resonance in medicine.