Granular Cell Astrocytoma: Report of a Case

We report here a rare case of granular cell astrocytoma. A 75-year-old man was admitted to Inha University Hospital with a three-month history of language deterioration. In a magnetic resonance imaging, a 6.5 cm-sized heterogeneous enhancing mass was seen in both the frontal lobes and the anterior genu of the corpus callosum. A stereotactic biopsy was performed. The tumor was composed of large and small round cells with abundant intracytoplasmic granules. The nuclei were bland, round to oval, and often eccentrically located. The cytoplasm of the tumor cells was positive for glial fibrillary acidic protein and S-100 protein.

[1]  P. Gattuso,et al.  Cytologic features of granular cell astrocytoma in crush preparations , 2011, Diagnostic cytopathology.

[2]  D. Nam,et al.  Cerebral granular cell tumor , 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

[3]  Sung-Hye Park,et al.  Granular cell astrocytoma. , 2007, Pathology, research and practice.

[4]  D. Brat,et al.  Infiltrative Astrocytomas With Granular Cell Features (Granular Cell Astrocytomas): A Study of Histopathologic Features, Grading, and Outcome , 2002, The American journal of surgical pathology.

[5]  C. Rickert,et al.  Morphological and immunohistochemical characterization of granular cells in non‐hypophyseal tumours of the central nervous system , 1997, Histopathology.

[6]  W. Markesbery,et al.  GRANULAR CELL TUMORS OF THE CENTRAL NERVOUS SYSTEM , 1973, Journal of neuropathology and experimental neurology.

[7]  M. Thom,et al.  Granular cell change in astrocytic tumors. , 1996, The American journal of surgical pathology.