Objective To evaluate the effectiveness of different comprehensive treatment strategies on patients with nonarteritic anterior ischemic optic neuropathy (NAION) at edema stage.Methods 352 cases (361 eyes) corresponded to the diagnosis criteria for NAION at acute stage and within 2 weeks，and judged by color photograph and FFA examination with optic disc edema，and detected by OCT were enrolled.Except D group (oral prednisone hormone therapy) 33 outpatient cases 33 eyes，and group E (internal medicine treatment) 31 outpatient cases of 32 eyes，patients were randomly divided into group A (methylprednisone vein impact joint vasodilators) 93 inpatient cases of 97 eyes，group B (methylprednisone impact joint dehydration reagent) 114 inpatient cases 116 eyes，C (methylprednisone impact joint mavericks blood to protein extracts) 81 inpatient cases of 83 eyes.All groups were analyzed by visual faction，photographic tomography and OCT after treatment within 1416 days.Results After different comprehensive treatments on NAION in each group，the recovery in group C is better than group A，group B or group D from visual faction，photographic tomography and OCT changes observation，groups A and B compared with group D were no obvious difference；A，B，C，D groups compared with group E were statistically significant.Conclusions Methyl prednisone venous blood joint impact mavericks blood to protein extracts treatment on NAION at edema period is positive to improve visual function and revolving the optic disc edema，and is a safe，effective，comprehensive method to cure NAION.