Structure‐Activity Relationships of Pyrazine‐Based CK2 Inhibitors: Synthesis and Evaluation of 2,6‐Disubstituted Pyrazines and 4,6‐Disubstituted Pyrimidines

Structually related to the known CK2 inhibitors, 2,6‐disubstituted pyrazine and 4,6‐disubstituted pyrimidine derivatives were synthesized and their inhibitory activities toward CK2α and CK2α′ were evaluated. Structure‐activity relationship study has revealed that several pyrazine derivatives bearing a (pyrrol‐3‐yl)acetic acid and a monosubstituted aniline possess potent inhibitory activities.

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