Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms

[1]  R. Moots,et al.  Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial , 2022, Nature Medicine.

[2]  Jingwen Wang,et al.  Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway. , 2022, International immunopharmacology.

[3]  Xuan-jun Wang,et al.  Roburic Acid Targets TNF to Inhibit the NF-κB Signaling Pathway and Suppress Human Colorectal Cancer Cell Growth , 2022, Frontiers in Immunology.

[4]  Xiaoli Wang,et al.  Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis , 2022, Critical Care.

[5]  G. Wang,et al.  Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL‐induced intracellular signaling pathways , 2021, Journal of cellular physiology.

[6]  H. Khan,et al.  Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer , 2021, BioFactors.

[7]  F. Oesch,et al.  The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases , 2021, Medicinal research reviews.

[8]  Jan Dudek,et al.  Pharmacological Inhibition of GLUT1 As a New Immunotherapeutic Approach After Myocardial Infarction. , 2021, Biochemical pharmacology.

[9]  Lihong Hu,et al.  Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation. , 2021, Pharmacological research.

[10]  Xun Sun,et al.  Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis , 2021, Nature Communications.

[11]  Q. Lv,et al.  Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway , 2021, Frontiers in Immunology.

[12]  Z. Cai,et al.  Metabolic reprogramming in macrophage responses , 2021, Biomarker research.

[13]  C. Weyand,et al.  The immunology of rheumatoid arthritis , 2020, Nature Immunology.

[14]  C. Taylor,et al.  Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology , 2020, The Journal of physiology.

[15]  Peng Liu,et al.  Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization. , 2020, Biomaterials.

[16]  J. Karlsson,et al.  Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities , 2020, Expert opinion on drug delivery.

[17]  F. Fenaille,et al.  Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages , 2020, Annals of the Rheumatic Diseases.

[18]  T. Otto,et al.  Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis , 2020, Nature Medicine.

[19]  W. Rathmell,et al.  Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma. , 2020, Cancer letters.

[20]  P. Canoll,et al.  HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models. , 2020, The Journal of clinical investigation.

[21]  A. Lane,et al.  Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase , 2020, Nature Communications.

[22]  Junsong Wang,et al.  4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects , 2019, Nature Communications.

[23]  G. Nagy,et al.  Failure of anti-TNF treatment in patients with rheumatoid arthritis: The pros and cons of the early use of alternative biological agents. , 2019, Autoimmunity reviews.

[24]  R. Giacomelli,et al.  Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases. , 2019, Autoimmunity reviews.

[25]  J. Moon,et al.  Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome, and immune responses in colitis. , 2019, Nature Materials.

[26]  K. Ley,et al.  Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages , 2019, Front. Immunol..

[27]  L. Mao,et al.  The ERK Pathway: Molecular Mechanisms and Treatment of Depression , 2019, Molecular Neurobiology.

[28]  Deli Wang,et al.  Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats , 2019, Molecules.

[29]  S. Papa,et al.  The ERK and JNK pathways in the regulation of metabolic reprogramming , 2018, Oncogene.

[30]  A. Lammertsma,et al.  The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis , 2018, Drug Delivery and Translational Research.

[31]  Kenli Li,et al.  iProX: an integrated proteome resource , 2018, Nucleic Acids Res..

[32]  Ajit S. Divakaruni,et al.  Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. , 2018, Cell metabolism.

[33]  Zengjun Guo,et al.  Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae-A traditional medicine: A review. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[34]  S. Loesgen,et al.  Measurement of Oxygen Consumption Rate (OCR) and Extracellular Acidification Rate (ECAR) in Culture Cells for Assessment of the Energy Metabolism. , 2018, Bio-protocol.

[35]  M. Buch.  Defining refractory rheumatoid arthritis , 2018, Annals of the rheumatic diseases.

[36]  Zhirong Zhong,et al.  Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy , 2018, Drug delivery.

[37]  G. Burmester,et al.  Novel treatment strategies in rheumatoid arthritis , 2017, The Lancet.

[38]  L. O’Neill,et al.  Mitochondria are the powerhouses of immunity , 2017, Nature Immunology.

[39]  Mei Chen,et al.  Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells , 2017, Journal of Inflammation.

[40]  Man Li,et al.  pH‐sensitive polymeric micelles for targeted delivery to inflamed joints , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[41]  A. Wen,et al.  Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats. , 2016, Journal of ethnopharmacology.

[42]  D. Veale,et al.  Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis , 2016, Nature Reviews Rheumatology.

[43]  Yukio Fujiwara,et al.  Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy. , 2016, Advanced drug delivery reviews.

[44]  Joël Eyer,et al.  The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle , 2016, Journal of neuroscience research.

[45]  M. Amiji,et al.  Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis. , 2015, Biomaterials.

[46]  Wei Li,et al.  HIF-1α pathway: role, regulation and intervention for cancer therapy , 2015, Acta pharmaceutica Sinica. B.

[47]  R. Xavier,et al.  mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity , 2014, Science.

[48]  L. O’Neill,et al.  Metabolic Reprograming in Macrophage Polarization , 2014, Front. Immunol..

[49]  Daniela Schuster,et al.  Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1 , 2014, Journal of natural products.

[50]  A. Prince,et al.  Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity , 2014, Nature.

[51]  P. Taylor,et al.  Tissue-resident macrophages , 2013, Nature Immunology.

[52]  A. Wen,et al.  Comparison of the anti-inflammatory and analgesic effects of Gentiana macrophylla Pall. and Gentiana straminea Maxim., and identification of their active constituents. , 2012, Journal of ethnopharmacology.

[53]  Li Juan Zhang,et al.  Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. , 2012, Biomaterials.

[54]  Alberto Mantovani,et al.  Orchestration of metabolism by macrophages. , 2012, Cell metabolism.

[55]  P. Low,et al.  A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. , 2009, Blood.

[56]  N. Denko,et al.  Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.

[57]  J. Kremer,et al.  IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial , 2008, Annals of the rheumatic diseases.

[58]  M. Ohori.  ERK inhibitors as a potential new therapy for rheumatoid arthritis. , 2008, Drug news & perspectives.

[59]  Stanley B. Cohen,et al.  Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. , 2006, Arthritis and rheumatism.

[60]  M. Dougados,et al.  Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. , 2005, The New England journal of medicine.

[61]  N. Sang,et al.  MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300* , 2003, The Journal of Biological Chemistry.

[62]  G. Semenza.  Signal transduction to hypoxia-inducible factor 1. , 2002, Biochemical pharmacology.

[63]  Jingwen Wang,et al.  Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway. , 2022, International immunopharmacology.

[64]  OUP accepted manuscript , 2021, Nucleic Acids Research.