Criteria for evaluating multiunit spike separation techniques

Multi-unit neural recordings often occur in neurophysiological studies, and a wide variety of techniques have been proposed to separate the multi-unit activity. In this paper we propose a method for evaluating the power of various multi-unit sorting techniques. The analysis can also be applied to a data set to determine whether a given multi-unit isolation technique can isolate a given set of wavelets to a specified statistical standard. The apparent separation matrix described in the paper is then used to evaluate the ability of four multi-unit isolation techniques to resolve a population of 8 units simultaneously recorded in the medial articular nerve of the cat.

[1]  M. J. R. Healy,et al.  Statistics with Applications to the Biological and Health Sciences , 1971 .

[2]  G. E. Loeb,et al.  Analysis and microelectronic design of tubular electrode arrays intended for chronic, multiple singleunit recording from captured nerve fibres , 1977, Medical and Biological Engineering and Computing.

[3]  B Conrad,et al.  A neuroelectric signal recognition system. , 1972, Electroencephalography and clinical neurophysiology.

[4]  Daniel K. Hartline,et al.  Separation of multi-unit nerve impulse trains by a multi-channel linear filter algorithm , 1975, Brain Research.

[5]  E M Schmidt,et al.  An instrument for separation of multiple-unit neuroelectric signals. , 1971, IEEE transactions on bio-medical engineering.

[6]  D J Mishelevich,et al.  On-line real-time digital computer separation of extracellular neuroelectric signals. , 1970, IEEE transactions on bio-medical engineering.

[7]  K I Naka,et al.  An attempt to analyze multi-unit recordings. , 1970, Electroencephalography and clinical neurophysiology.

[8]  W. Heetderks,et al.  Partition of gross peripheral nerve activity into single unit responses by correlation techniques. , 1975, Science.

[9]  W. N. Ross,et al.  Changes in absorption, fluorescence, dichroism, and birefringence in stained giant axons: Optical measurement of membrane potential , 1977, The Journal of Membrane Biology.

[10]  I. M. Jacobs,et al.  Principles of Communication Engineering , 1965 .

[11]  M. Abeles,et al.  Multispike train analysis , 1977, Proceedings of the IEEE.

[12]  Jess Marcum,et al.  A statistical theory of target detection by pulsed radar , 1948, IRE Trans. Inf. Theory.

[13]  E. Glaser Separation of Neuronal Activity by Waveform Analysis , 1971 .

[14]  R. Pickard,et al.  Printed circuit microelectrodes and their application to honeybee brain. , 1976, The Journal of experimental biology.