Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.

[1]  Brian M. Baker,et al.  The basis for limited specificity and MHC restriction in a T cell receptor interface , 2013, Nature Communications.

[2]  J. Boulter,et al.  Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode , 2013, Front. Immunol..

[3]  B. Baker,et al.  Structural and dynamic control of T‐cell receptor specificity, cross‐reactivity, and binding mechanism , 2012, Immunological reviews.

[4]  D. Kranz,et al.  Design of T cell receptor libraries with diverse binding properties to examine adoptive T cell responses , 2012, Gene Therapy.

[5]  S. Holland,et al.  The T-cell receptor is not hardwired to engage MHC ligands , 2012, Proceedings of the National Academy of Sciences.

[6]  R. Mariuzza,et al.  Structural insights into the editing of germ-line–encoded interactions between T-cell receptor and MHC class II by Vα CDR3 , 2012, Proceedings of the National Academy of Sciences.

[7]  Zhiping Weng,et al.  Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism , 2012, The Journal of Immunology.

[8]  B. Baker,et al.  Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism. , 2011, Journal of molecular biology.

[9]  B. Baker,et al.  TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms , 2011, The Journal of Immunology.

[10]  B. Baker,et al.  Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. , 2011, Protein engineering, design & selection : PEDS.

[11]  James McCluskey,et al.  Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability , 2010, Proceedings of the National Academy of Sciences.

[12]  B. Baker,et al.  Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity. , 2009, Molecular immunology.

[13]  D. Kranz,et al.  Recurrence of Intracranial Tumors following Adoptive T Cell Therapy Can Be Prevented by Direct and Indirect Killing Aided by High Levels of Tumor Antigen Cross-Presented on Stromal Cells1 , 2009, The Journal of Immunology.

[14]  G. Gao,et al.  Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor* , 2009, The Journal of Biological Chemistry.

[15]  P. Marrack,et al.  Germline-encoded amino acids in the αβ T cell receptor control thymic selection , 2009, Nature.

[16]  Zhiping Weng,et al.  Structure‐based design of a T‐cell receptor leads to nearly 100‐fold improvement in binding affinity for pepMHC , 2009, Proteins.

[17]  L. K. Ely,et al.  The molecular basis of TCR germline bias for MHC is surprisingly simple , 2009, Nature Immunology.

[18]  R. Phillips,et al.  Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor , 2008, Nature Medicine.

[19]  David M. Kranz,et al.  Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation1 , 2008, The Journal of Immunology.

[20]  Philippa Marrack,et al.  Evolutionarily conserved amino acids that control TCR-MHC interaction. , 2008, Annual review of immunology.

[21]  P. Marrack,et al.  Germline-encoded recognition of diverse glycolipids by natural killer T cells , 2007, Nature Immunology.

[22]  Jennifer Maynard,et al.  Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon' , 2007, Nature Immunology.

[23]  K. Garcia,et al.  How a Single T Cell Receptor Recognizes Both Self and Foreign MHC , 2007, Cell.

[24]  P. Marrack,et al.  Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide , 2006, Nature Immunology.

[25]  Brian M Baker,et al.  T cell receptor recognition via cooperative conformational plasticity. , 2006, Journal of molecular biology.

[26]  T. Schumacher,et al.  Generation of peptide–MHC class I complexes through UV-mediated ligand exchange , 2006, Nature Protocols.

[27]  Yi Li,et al.  Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide‐MHC without increasing apparent cross‐reactivity , 2006, Protein science : a publication of the Protein Society.

[28]  Robyn L Stanfield,et al.  How TCRs bind MHCs, peptides, and coreceptors. , 2006, Annual review of immunology.

[29]  T. Schumacher,et al.  Design and use of conditional MHC class I ligands , 2006, Nature Medicine.

[30]  P. Katsamba,et al.  Analyzing a kinetic titration series using affinity biosensors. , 2006, Analytical biochemistry.

[31]  David M Kranz,et al.  Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Yi Li,et al.  Directed evolution of human T-cell receptors with picomolar affinities by phage display , 2005, Nature Biotechnology.

[33]  Brian M Baker,et al.  Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand. , 2005, Journal of molecular biology.

[34]  Matthew R. Clutter,et al.  High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. , 2005, Journal of molecular biology.

[35]  L. K. Ely,et al.  The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition , 2005, Nature Immunology.

[36]  D. Busch,et al.  Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro1 , 2004, The Journal of Immunology.

[37]  H. Steven Wiley,et al.  Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library , 2003, Nature Biotechnology.

[38]  D. Speiser,et al.  Antigenicity and immunogenicity of Melan‐A/MART‐1 derived peptides as targets for tumor reactive CTL in human melanoma , 2002, Immunological reviews.

[39]  Mark M. Davis,et al.  Two-step binding mechanism for T-cell receptor recognition of peptide–MHC , 2002, Nature.

[40]  Raimund J. Ober,et al.  Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  K D Wittrup,et al.  Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Michele C. Kieke,et al.  Directed evolution of a stable scaffold for T-cell receptor engineering , 2000, Nature Biotechnology.

[43]  K D Wittrup,et al.  In vitro evolution of a T cell receptor with high affinity for peptide/MHC. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[44]  S. Jameson,et al.  Role of 2c T Cell Receptor Residues in the Binding of Self–And Allo–Major Histocompatibility Complexes , 2000, The Journal of experimental medicine.

[45]  P. Romero,et al.  Induction of Potent Antitumor CTL Responses by Recombinant Vaccinia Encoding a Melan-A Peptide Analogue , 2000, The Journal of Immunology.

[46]  D. Kranz,et al.  Binding energetics of T-cell receptors: correlation with immunological consequences. , 1999, Immunology today.

[47]  B M Baker,et al.  Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. , 1999, Immunity.

[48]  G. Parmiani,et al.  A superagonist variant of peptide MART1/Melan A27-35 elicits anti-melanoma CD8+ T cells with enhanced functional characteristics: implication for more effective immunotherapy. , 1999, Cancer research.

[49]  P. Romero,et al.  Diversity of the fine specificity displayed by HLA-A*0201-restricted CTL specific for the immunodominant Melan-A/MART-1 antigenic peptide. , 1998, Journal of immunology.

[50]  K. Garcia,et al.  Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition , 1998 .

[51]  P. Romero,et al.  Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues. , 1998, Journal of immunology.

[52]  Partho Ghosh,et al.  Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 , 1996, Nature.

[53]  Mark I. Greene,et al.  Control of MHC Restriction by TCR Vα CDR1 and CDR2 , 1996, Science.

[54]  R. J. Cohen,et al.  Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. , 1994, Immunity.

[55]  K. D. Hardman,et al.  Characterization of a single-chain T-cell receptor expressed in Escherichia coli. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[56]  S. Ho,et al.  Site-directed mutagenesis by overlap extension using the polymerase chain reaction. , 1989, Gene.

[57]  D. Kranz,et al.  Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. , 2009, Methods in molecular biology.

[58]  David M. Kranz,et al.  TCRs with high affinity for foreign pMHC show self-reactivity , 2003, Nature Immunology.