There have been few studies on the cosmetic efficacy of Coprinus comatus, Cordyceps militaris, and Pleurotus geesteranus. This article aims to compare the cosmetic effects of the mycelium, fermentation broth, and mycelium and fermentation broth mixture of liquid-fermented C. comatus, C. militaris, and P. geesteranus. Our results verified that these three edible mushrooms all showed excellent antioxidant, moisturizing, and whitening effects. Comparatively, we found that the cosmetic effects of C. comatus were superior to C. militaris and P. geesteranus. Therefore, we speculate that among the three edible mushrooms, C. comatus will be the most suitable to be used as a basis for cosmeceutical formulations to tackle skin aging and hyperpigmentation. This research aims to provide a basis for the study of the cosmetic effects of edible mushrooms.