Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus.

[1]  Zhi‐qiang Wang,et al.  Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor. , 2016, General and comparative endocrinology.

[2]  Y. Tao,et al.  Pharmacologic analyses of four chicken melanocortin-4 receptor mutations. , 2016, Domestic animal endocrinology.

[3]  Clifford J. Tabin,et al.  Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions , 2015, Proceedings of the National Academy of Sciences.

[4]  S. Deng,et al.  Effects of temperature and fish oil supplementation on ovarian development and foxl2 mRNA expression in spotted scat Scatophagus argus. , 2015, Journal of fish biology.

[5]  Y. Tao Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists. , 2014, Advances in pharmacology.

[6]  J. Holst,et al.  The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. , 2014, Cell metabolism.

[7]  Y. Tao,et al.  A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants , 2014, International journal of biological sciences.

[8]  J. Prokop,et al.  MOLECULAR EVOLUTION OF GPCRS Melanocortin/melanocortin receptors , 2014 .

[9]  Hongwei Wu,et al.  Cloning, distribution and effects of fasting status of melanocortin 4 receptor (MC4R) in Schizothorax prenanti. , 2013, Gene.

[10]  R. Cone,et al.  Development of an assay for high-throughput energy expenditure monitoring in the zebrafish. , 2013, Zebrafish.

[11]  R. Cone,et al.  Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish , 2013, Science.

[12]  M. Ridderstråle,et al.  Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity , 2013, Science.

[13]  A. Hinney,et al.  Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis. , 2013, Progress in molecular biology and translational science.

[14]  Y. Tao,et al.  Functions of Transmembrane Domain 6 in Human Melanocortin‐4 Receptor , 2009, Journal of molecular endocrinology.

[15]  G. Yoshizaki,et al.  Characterization of melanocortin 4 receptor in Snakeskin Gourami and its expression in relation to daily feed intake and short-term fasting. , 2011, General and comparative endocrinology.

[16]  M. Ryan,et al.  Determination of Onset of Sexual Maturation and Mating Behavior by Melanocortin Receptor 4 Polymorphisms , 2010, Current Biology.

[17]  Y. Tao The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. , 2010, Endocrine reviews.

[18]  G. Flik,et al.  Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[19]  Gregory J Morton,et al.  Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[20]  Y. Tao Mutations in melanocortin-4 receptor and human obesity. , 2009, Progress in molecular biology and translational science.

[21]  O. Ilnytska,et al.  The Role of the Agouti-Related Protein in Energy Balance Regulation , 2008, Cellular and Molecular Life Sciences.

[22]  H. Schiöth,et al.  Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri. , 2008, General and comparative endocrinology.

[23]  Y. Tao Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects. , 2007, Biochimica et biophysica acta.

[24]  H. Schiöth,et al.  Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes , 2007, BMC Evolutionary Biology.

[25]  R. Cone Studies on the physiological functions of the melanocortin system. , 2006, Endocrine reviews.

[26]  Helgi B. Schiöth,et al.  Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes , 2005, Peptides.

[27]  Y. Tao Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity , 2005, Molecular and Cellular Endocrinology.

[28]  R. Dores,et al.  Trends in the evolution of the proopiomelanocortin gene. , 2005, General and comparative endocrinology.

[29]  M. Ferin,et al.  Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. , 2005, Endocrinology.

[30]  B. Conklin,et al.  Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. , 2004, The Journal of clinical investigation.

[31]  Robert Fredriksson,et al.  Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes. , 2004, The Biochemical journal.

[32]  Kanji A. Takahashi,et al.  Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system , 2004, Nature Neuroscience.

[33]  Robert Fredriksson,et al.  The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. , 2004, Molecular biology and evolution.

[34]  T. Schöneberg,et al.  Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity* , 2003, Journal of Biological Chemistry.

[35]  J. Wild,et al.  Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. , 2003, Endocrinology.

[36]  D. Segaloff,et al.  Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. , 2003, Endocrinology.

[37]  H. Schiöth,et al.  The central melanocortin system regulates food intake in goldfish , 2003, Regulatory Peptides.

[38]  Martin S. Taylor,et al.  Sequence Characterization of Teleost Fish Melanocortin Receptors , 2003, Annals of the New York Academy of Sciences.

[39]  H. Schiöth,et al.  Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake. , 2003, Endocrinology.

[40]  Tim Cheetham,et al.  Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. , 2003, The New England journal of medicine.

[41]  I. Gantz,et al.  The melanocortin system. , 2003, American journal of physiology. Endocrinology and metabolism.

[42]  D. Larhammar,et al.  Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system. , 2003, European journal of biochemistry.

[43]  D. Johnston,et al.  Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. , 2002, Journal of medicinal chemistry.

[44]  Christopher P Austin,et al.  A role for the melanocortin 4 receptor in sexual function , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Robert Fredriksson,et al.  One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology , 2002, Journal of neurochemistry.

[46]  R. Cone,et al.  Expression of Functional Melanocortin-4 Receptor in the Hypothalamic GT1-1 Cell Line , 2001, Neuroendocrinology.

[47]  R. Cone,et al.  A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse. , 2000, Endocrinology.

[48]  Yue Feng,et al.  Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass , 2000, Nature Genetics.

[49]  R. Cone,et al.  A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. , 2000, Endocrinology.

[50]  J. Hebebrand,et al.  Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. , 1999, The Journal of clinical endocrinology and metabolism.

[51]  S. Takeuchi,et al.  Melanocortin receptor genes in the chicken--tissue distributions. , 1998, General and comparative endocrinology.

[52]  K. Clément,et al.  A frameshift mutation in human MC4R is associated with a dominant form of obesity , 1998, Nature Genetics.

[53]  S. O’Rahilly,et al.  A frameshift mutation in MC4R associated with dominantly inherited human obesity , 1998, Nature Genetics.

[54]  J. Shutter,et al.  Overexpression of Agrt leads to obesity in transgenic mice , 1997, Nature Genetics.

[55]  G. Barsh,et al.  Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. , 1997, Science.

[56]  M. Tota,et al.  ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. , 1997, Biochemical and biophysical research communications.

[57]  R. Cone,et al.  Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.

[58]  Victor J. Hruby,et al.  Role of melanocortinergic neurons in feeding and the agouti obesity syndrome , 1997, Nature.

[59]  J. Geisler,et al.  Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Joshua R. Smith,et al.  Design and pharmacology of peptide mimetics. , 1995, Advances in pharmacology.

[61]  M. Mortrud,et al.  Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. , 1994, Molecular endocrinology.

[62]  S. Watson,et al.  Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. , 1993, The Journal of biological chemistry.

[63]  J. Funder,et al.  Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. , 1988, Endocrine reviews.

[64]  H. Okayama,et al.  High-efficiency transformation of mammalian cells by plasmid DNA. , 1987, Molecular and cellular biology.

[65]  V. Hruby,et al.  4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[66]  R. Schwyzer,et al.  ACTH: A SHORT INTRODUCTORY REVIEW * , 1977, Annals of the New York Academy of Sciences.

[67]  D. Kipnis,et al.  Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[68]  V. Hruby,et al.  4-Norleucine , 7D-phenylalanine-a-melanocyte-stimulating hormone : A highly potent a-melanotropin with ultralong biological activity ( amino acid racemization / peptide degradation / adenylate cyclase / tyrosinase / melanoma ) , 2022 .