Determination Methods of the Risk Factors in Food Based on Nanozymes: A Review

Food safety issues caused by foodborne pathogens, chemical pollutants, and heavy metals have aroused widespread concern because they are closely related to human health. Nanozyme-based biosensors have excellent characteristics such as high sensitivity, selectivity, and cost-effectiveness and have been used to detect the risk factors in foods. In this work, the common detection methods for pathogenic microorganisms, toxins, heavy metals, pesticide residues, veterinary drugs, and illegal additives are firstly reviewed. Then, the principles and applications of immunosensors based on various nanozymes are reviewed and explained. Applying nanozymes to the detection of pathogenic bacteria holds great potential for real-time evaluation and detection protocols for food risk factors.

[1]  Lingwen Zeng,et al.  "Three-in-one" Zr-MOF Multifunctional Carrier-mediated Fluorescent and Colorimetric Dual-signal Readout Biosensing Platform to Enhance Analytical Performance. , 2022, ACS applied materials & interfaces.

[2]  Xueli Luo,et al.  A versatile platform for colorimetric, fluorescence and photothermal multi-mode glyphosate sensing by carbon dots anchoring ferrocene metal-organic framework nanosheet. , 2022, Journal of hazardous materials.

[3]  Jianming Pan,et al.  Bifunctional Mn-Doped N-Rich Carbon Dots with Tunable Photoluminescence and Oxidase-Mimetic Activity Enabling Bimodal Ratiometric Colorimetric/Fluorometric Detection of Nitrite. , 2022, ACS applied materials & interfaces.

[4]  Ruofan Zhou,et al.  A Smartphone Colorimetric Sensor Based on Pt@Au Nanozyme for Visual and Quantitative Detection of Omethoate , 2022, Foods.

[5]  Liyuan Wu,et al.  Catalase-Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications. , 2022, Small.

[6]  Lin Li,et al.  Porphyrin NanoMOFs as a catalytic label in a nanozyme-linked immunosorbent assay for Aflatoxin B1 detection. , 2022, Analytical biochemistry.

[7]  Xiang Gao,et al.  Polydopamine-based nanozyme with dual-recognition strategy-driven fluorescence-colorimetric dual-mode platform for Listeria monocytogenes detection. , 2022, Journal of hazardous materials.

[8]  Ruijie Deng,et al.  A colorimetric smartphone-based platform for pesticides detection using Fe-N/C single-atom nanozyme as oxidase mimetics. , 2022, Journal of hazardous materials.

[9]  Daohong Zhang,et al.  Nature-inspired nanozymes as signal markers for in-situ signal amplification strategy: A portable dual-colorimetric immunochromatographic analysis based on smartphone. , 2022, Biosensors & bioelectronics.

[10]  R. Paolesse,et al.  Naked-Eye Detection of Morphine by Au@Ag Nanoparticles-Based Colorimetric Chemosensors , 2022, Sensors.

[11]  Yingju Liu,et al.  Zeolitic imidazolate frameworks-derived hollow Co/N-doped CNTs as oxidase-mimic for colorimetric-fluorescence immunoassay of ochratoxin A , 2022, Sensors and Actuators B: Chemical.

[12]  F. Mu,et al.  The preparation of Fe-based peroxidase mimetic nanozymes and for the electrochemical detection of histamine , 2022, Journal of Electroanalytical Chemistry.

[13]  Hong Wang,et al.  Prussian blue nanoparticles-enabled sensitive and accurate ratiometric fluorescence immunoassay for histamine. , 2021, Food chemistry.

[14]  L. Yu,et al.  A novel selective detection method for sulfide in food systems based on the GMP-Cu nanozyme with laccase activity. , 2021, Talanta.

[15]  Peng Liu,et al.  Coupling Diazotization with Oxidase-mimetic Catalysis to Realize Dual-mode Double-ratiometric Colorimetric and Electrochemical Sensing of Nitrite , 2021, Sensors and Actuators B: Chemical.

[16]  Jiao Hu,et al.  Nanozyme sensor based-on platinum-decorated polymer nanosphere for rapid and sensitive detection of Salmonella typhimurium with the naked eye , 2021 .

[17]  Rajesh Ramanathan,et al.  Detection of pesticides using nanozymes: Trends, challenges and outlook , 2021, TrAC Trends in Analytical Chemistry.

[18]  A. Elmarakbi,et al.  Progress in sensory devices of pesticides, pathogens, coronavirus, and chemical additives and hazards in food assessment: Food safety concerns , 2021, Progress in Materials Science.

[19]  Long Wu,et al.  Nanozyme Applications: A Glimpse of Insight in Food Safety , 2021, Frontiers in Bioengineering and Biotechnology.

[20]  Lele Wang,et al.  A competitive colorimetric aptasensor transduced by hybridization chain reaction-facilitated catalysis of AuNPs nanozyme for highly sensitive detection of saxitoxin. , 2021, Analytica chimica acta.

[21]  Peng Liu,et al.  Ratiometric Colorimetric Detection of Nitrite Realized by Stringing Nanozyme Catalysis and Diazotization Together , 2021, Biosensors.

[22]  Haoming Jiang,et al.  An In Situ Generated Prussian Blue Nanoparticle-Mediated Multimode Nanozyme-Linked Immunosorbent Assay for the Detection of Aflatoxin B1. , 2021, ACS applied materials & interfaces.

[23]  L. Zeng,et al.  Detection of enrofloxacin by flow injection chemiluminescence immunoassay based on cobalt hydroxide nanozyme , 2021, Microchimica Acta.

[24]  Yuangen Wu,et al.  Porous Co3O4 nanodisks as robust peroxidase mimetics in an ultrasensitive colorimetric sensor for the rapid detection of multiple heavy metal residues in environmental water samples. , 2021, Journal of hazardous materials.

[25]  J. Moses,et al.  A Review on Recent Developments and Applications of Nanozymes in Food Safety and Quality Analysis , 2021, Food Analytical Methods.

[26]  Kiho Lee,et al.  Veterinary Drug Residues in Animal-Derived Foods: Sample Preparation and Analytical Methods , 2021, Foods.

[27]  Yingju Liu,et al.  Template-assisted Cu2O@Fe(OH)3 yolk-shell nanocages as biomimetic peroxidase: A multi-colorimetry and ratiometric fluorescence separated-type immunosensor for the detection of ochratoxin A. , 2021, Journal of hazardous materials.

[28]  Zhi Xu,et al.  Novel chloramphenicol sensor based on aggregation-induced electrochemiluminescence and nanozyme amplification. , 2021, Biosensors & bioelectronics.

[29]  Rui Wang,et al.  A sensitive biomimetic enzyme-linked immunoassay method based on Au@Pt@Au composite nanozyme label and molecularly imprinted biomimetic antibody for histamine detection , 2021, Food and Agricultural Immunology.

[30]  Yuen Wu,et al.  Single-atom nanozyme enabled fast and highly sensitive colorimetric detection of Cr(VI). , 2020, Journal of hazardous materials.

[31]  C. Tan,et al.  Interactions between Food Hazards and Intestinal Barrier: Impact on Foodborne Diseases. , 2020, Journal of agricultural and food chemistry.

[32]  Wei Liu,et al.  Norfloxacin detection based on the peroxidase-like activity enhancement of gold nanoclusters , 2020, Analytical and Bioanalytical Chemistry.

[33]  Long Wu,et al.  Nanozyme and aptamer- based immunosorbent assay for aflatoxin B1. , 2020, Journal of hazardous materials.

[34]  N. Daéid,et al.  Rapid and highly selective colorimetric detection of nitrite based on the catalytic-enhanced reaction of mimetic Au nanoparticle-CeO2 nanoparticle-graphene oxide hybrid nanozyme. , 2020, Talanta.

[35]  Yanbin Li,et al.  Biosensors for rapid detection of Salmonella in food: A review. , 2020, Comprehensive reviews in food science and food safety.

[36]  Jiansheng Cui,et al.  Ratiometric Dual Signal-Enhancing-Based Electrochemical Biosensor for Ultrasensitive Kanamycin Detection. , 2020, ACS applied materials & interfaces.

[37]  Yingju Liu,et al.  A colorimetric immunoassay based on cobalt hydroxide nanocages as oxidase mimics for detection of ochratoxin A. , 2020, Analytica chimica acta.

[38]  T. Rohani Bastami,et al.  AuNPs@PMo12 nanozyme: highly oxidase mimetic activity for sensitive and specific colorimetric detection of acetaminophen , 2020, RSC advances.

[39]  Yunhui Cheng,et al.  A nanozyme-linked immunosorbent assay based on metal-organic frameworks (MOFs) for sensitive detection of aflatoxin B1. , 2020, Food chemistry.

[40]  Renald Blundell,et al.  Heavy metal pollution in the environment and their toxicological effects on humans , 2020, Heliyon.

[41]  Lingdi Zhao,et al.  Highly sensitive detection of salbutamol by ALP-mediated plasmonic ELISA based on controlled growth of AgNPs , 2020 .

[42]  Jing Sun,et al.  Functional nanozyme mediated multi-readout and label-free lateral flow immunoassay for rapid detection of Escherichia coli O157:H7. , 2020, Food chemistry.

[43]  Lei Han,et al.  White Peroxidase‐Mimicking Nanozymes: Colorimetric Pesticide Assay without Interferences of O2 and Color , 2020, Advanced Functional Materials.

[44]  Lijun Han,et al.  Nanozyme sensor arrays based on heteroatom-doped graphene for detecting pesticides. , 2020, Analytical chemistry.

[45]  Yuangen Wu,et al.  A facile colorimetric sensor for ultrasensitive and selective detection of Lead(II) in environmental and biological samples based on intrinsic peroxidase-mimic activity of WS2 nanosheets. , 2020, Analytica chimica acta.

[46]  Zheng-Jun Xie,et al.  Colorimetric determination of Pb2+ ions based on surface leaching of Au@Pt nanoparticles as peroxidase mimic , 2020, Microchimica Acta.

[47]  Junhui He,et al.  Portable Hg2+ Nanosensor with ppt Level Sensitivity Using Nanozyme as the Recognition Unit, Enrichment Carrier, and Signal Amplifier. , 2020, ACS applied materials & interfaces.

[48]  V. Petrenko,et al.  Colorimetric Assay of Bacterial Pathogen Based on Co3O4 Magnetic Nanozyme Conjugated with Specific Fusion Phage Protein and Magnetophoretic Chromatography. , 2020, ACS applied materials & interfaces.

[49]  Fangying Wu,et al.  Using target-specific aptamers to enhance the peroxidase-like activity of gold nanoclusters for colorimetric detection of tetracycline antibiotics. , 2020, Talanta.

[50]  Bo Liang,et al.  Displaying of acetylcholinesterase mutants on surface of yeast for ultra-trace fluorescence detection of organophosphate pesticides with gold nanoclusters. , 2020, Biosensors & bioelectronics.

[51]  Maohua Wang,et al.  An optical biosensor for rapid detection of Salmonella Typhimurium based on porous gold@platinum nanocatalyst and 3D fluidic chip. , 2019, ACS sensors.

[52]  L. Tang,et al.  Ultrathin PtNi nanozyme based self-powered photoelectrochemical aptasensor for ultrasensitive chloramphenicol detection. , 2019, Biosensors & bioelectronics.

[53]  Zhixian Gao,et al.  A Colorimetric Strip for Rapid Detection and Real-time Monitoring of Histamine in Fish Based on Self-assembled PDA Vesicles. , 2019, Analytical chemistry.

[54]  Hongshun Yang,et al.  Synthesis of magnetic nanoparticles to detect Sudan dye adulteration in chilli powders. , 2019, Food chemistry.

[55]  P. Hsu,et al.  DNA engineered copper oxide-based nanocomposites with multiple enzyme-like activities for specific detection of mercury species in environmental and biological samples. , 2019, Analytica chimica acta.

[56]  Dan Du,et al.  2D Graphene Oxide/Fe-MOF Nanozyme Nest with Superior Peroxidase-Like Activity and Its Application for Detection of Woodsmoke Exposure Biomarker. , 2019, Analytical chemistry.

[57]  Jichao Liu,et al.  Recent progress in the construction of nanozyme-based biosensors and their applications to food safety assay , 2019, TrAC Trends in Analytical Chemistry.

[58]  Da-Wen Sun,et al.  Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications. , 2019, Comprehensive reviews in food science and food safety.

[59]  Shaobin He,et al.  Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion , 2019, Chinese Chemical Letters.

[60]  Heshmatollah Ebrahimi-Najafabadi,et al.  Determination of toxic heavy metals in rice samples using ultrasound assisted emulsification microextraction combined with inductively coupled plasma optical emission spectroscopy. , 2019, Food chemistry.

[61]  Y. Kong,et al.  Fabrication of CuO nanoparticles-decorated 3D N-doped porous carbon as electrochemical sensing platform for the detection of Sudan I. , 2019, Food chemistry.

[62]  Peng Huang,et al.  Nanozyme: new horizons for responsive biomedical applications. , 2019, Chemical Society reviews.

[63]  H. Beitollahi,et al.  Highly sensitive electrochemical sensor based on La3+-doped Co3O4 nanocubes for determination of sudan I content in food samples. , 2019, Food chemistry.

[64]  Xiyun Yan,et al.  Nanozymes: From New Concepts, Mechanisms, and Standards to Applications. , 2019, Accounts of chemical research.

[65]  Jianding Qiu,et al.  Covalent Organic Framework Nanosheet-Based Ultrasensitive and Selective Colorimetric Sensor for Trace Hg2+ Detection , 2019, ACS Sustainable Chemistry & Engineering.

[66]  Yingju Liu,et al.  Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme. , 2019, Analytica chimica acta.

[67]  Peng Li,et al.  Nanozyme-assisted technique for dual mode detection of organophosphorus pesticide. , 2019, Ecotoxicology and environmental safety.

[68]  Jie Du,et al.  Enhanced His@AuNCs oxidase-like activity by reduced graphene oxide and its application for colorimetric and electrochemical detection of nitrite , 2019, Analytical and Bioanalytical Chemistry.

[69]  Yi Chen,et al.  Determination of multi-pesticide residues in green tea with a modified QuEChERS protocol coupled to HPLC-MS/MS. , 2019, Food chemistry.

[70]  Xiaogang Qu,et al.  Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications. , 2019, Chemical reviews.

[71]  A. Khataee,et al.  Sensitive biosensing of organophosphate pesticides using enzyme mimics of magnetic ZIF-8. , 2019, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[72]  V. Adam,et al.  Current Trends in Detection of Histamine in Food and Beverages. , 2019, Journal of agricultural and food chemistry.

[73]  Wenxin Zhu,et al.  Portable Colorimetric Detection of Mercury(II) Based on a Non-Noble Metal Nanozyme with Tunable Activity. , 2019, Inorganic chemistry.

[74]  Lin Xu,et al.  On-Site Ultrasensitive Detection Paper for Multiclass Chemical Contaminants via Universal Bridge-Antibody Labeling: Mycotoxin and Illegal Additives in Milk as an Example. , 2018, Analytical chemistry.

[75]  Wensen Liu,et al.  Hemin-incorporated nanoflowers as enzyme mimics for colorimetric detection of foodborne pathogenic bacteria. , 2018, Bioorganic & medicinal chemistry letters.

[76]  Jianping Li,et al.  A Cu(II)-anchored unzipped covalent triazine framework with peroxidase-mimicking properties for molecular imprinting–based electrochemiluminescent detection of sulfaquinoxaline , 2018, Microchimica Acta.

[77]  Zhongbin Luo,et al.  Platinum Nanozyme-Catalyzed Gas Generation for Pressure-Based Bioassay Using Polyaniline Nanowires-Functionalized Graphene Oxide Framework. , 2018, Analytical chemistry.

[78]  Kallol K. Ghosh,et al.  Gold nanoprobe for inhibition and reactivation of acetylcholinesterase: An application to detection of organophosphorus pesticides , 2018, Sensors and Actuators B: Chemical.

[79]  Wei Li,et al.  In Situ Synthesis of Gold Nanoparticles/Metal-Organic Gels Hybrids with Excellent Peroxidase-Like Activity for Sensitive Chemiluminescence Detection of Organophosphorus Pesticides. , 2018, ACS applied materials & interfaces.

[80]  Xiaogang Qu,et al.  Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications. , 2018, Angewandte Chemie.

[81]  Kun Xu,et al.  Colorimetric immunoassay for Listeria monocytogenes by using core gold nanoparticles, silver nanoclusters as oxidase mimetics, and aptamer-conjugated magnetic nanoparticles , 2018, Microchimica Acta.

[82]  P. Skládal,et al.  Prussian Blue Nanoparticles as a Catalytic Label in a Sandwich Nanozyme-Linked Immunosorbent Assay. , 2018, Analytical chemistry.

[83]  Yang Song,et al.  MnO2 Nanosheet-Carbon Dots Sensing Platform for Sensitive Detection of Organophosphorus Pesticides. , 2017, Analytical chemistry.

[84]  Jinghong Li,et al.  Colorimetric aptasensor for the detection of Salmonella enterica serovar typhimurium using ZnFe2O4-reduced graphene oxide nanostructures as an effective peroxidase mimetics. , 2017, International journal of food microbiology.

[85]  Yang Song,et al.  Nanozyme-Mediated Dual Immunoassay Integrated with Smartphone for Use in Simultaneous Detection of Pathogens. , 2017, ACS applied materials & interfaces.

[86]  Xin Lu,et al.  Nontargeted screening of chemical contaminants and illegal additives in food based on liquid chromatography–high resolution mass spectrometry , 2017 .

[87]  Hui Xu,et al.  A Simple Assay for Ultrasensitive Colorimetric Detection of Ag+ at Picomolar Levels Using Platinum Nanoparticles , 2017, Sensors.

[88]  Yang Song,et al.  Carbon quantum dots as fluorescence resonance energy transfer sensors for organophosphate pesticides determination. , 2017, Biosensors & bioelectronics.

[89]  Subhas Mukhopadhyay,et al.  Detection Methodologies for Pathogen and Toxins: A Review , 2017, Sensors.

[90]  S. G. Harroun,et al.  Metal-deposited bismuth oxyiodide nanonetworks with tunable enzyme-like activity: sensing of mercury and lead ions , 2017 .

[91]  R. Darnell,et al.  An initial characterization of aflatoxin B1 contamination of maize sold in the principal retail markets of Kigali, Rwanda , 2017 .

[92]  H. J. van der Fels-Klerx,et al.  Overview of Food Safety Hazards in the European Dairy Supply Chain. , 2017, Comprehensive reviews in food science and food safety.

[93]  Q. Hu,et al.  Simultaneous determination of arsenic and mercury species in rice by ion-pairing reversed phase chromatography with inductively coupled plasma mass spectrometry. , 2016, Food chemistry.

[94]  Dan Du,et al.  Recent progress on nanomaterial-based biosensors for veterinary drug residues in animal-derived food , 2016 .

[95]  K. Feller,et al.  Fast and sensitive detection of ochratoxin A in red wine by nanoparticle-enhanced SPR. , 2016, Analytica chimica acta.

[96]  Uroš Andjelković,et al.  Foodborne pathogens and their toxins. , 2016, Journal of proteomics.

[97]  F. Verpoort,et al.  Metal organic frameworks mimicking natural enzymes: a structural and functional analogy. , 2016, Chemical Society reviews.

[98]  Fatimah Ibrahim,et al.  A microfluidic lab-on-a-disc integrated loop mediated isothermal amplification for foodborne pathogen detection , 2016 .

[99]  Giuseppe Maruccio,et al.  A multipurpose biochip for food pathogen detection , 2016 .

[100]  J. Żmudzki,et al.  Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry. , 2016, Food chemistry.

[101]  Lizeng Gao,et al.  Nanozymes: an emerging field bridging nanotechnology and biology , 2016, Science China Life Sciences.

[102]  B Stephen Inbaraj,et al.  Nanomaterial-based sensors for detection of foodborne bacterial pathogens and toxins as well as pork adulteration in meat products , 2015, Journal of food and drug analysis.

[103]  I. Kang,et al.  Colorimetric detection of pathogenic bacteria using platinum-coated magnetic nanoparticle clusters and magnetophoretic chromatography. , 2015, Analytica chimica acta.

[104]  H. G. Ramya,et al.  Pesticide: An Appraisal on Human Health Implications , 2015, Proceedings of the National Academy of Sciences, India Section B: Biological Sciences.

[105]  Jian Ji,et al.  Electrochemical Genosensor To Detect Pathogenic Bacteria (Escherichia coli O157:H7) As Applied in Real Food Samples (Fresh Beef) To Improve Food Safety and Quality Control. , 2015, Journal of agricultural and food chemistry.

[106]  Tarun Kumar Sharma,et al.  Aptamer-mediated 'turn-off/turn-on' nanozyme activity of gold nanoparticles for kanamycin detection. , 2014, Chemical communications.

[107]  Tarun Kumar Sharma,et al.  Aptamer-controlled reversible inhibition of gold nanozyme activity for pesticide sensing. , 2014, Analytical chemistry.

[108]  Hengwei Lin,et al.  Paper-based colorimetric array test strip for selective and semiquantitative multi-ion analysis: simultaneous detection of Hg²⁺, Ag⁺, and Cu²⁺. , 2014, Analytical chemistry.

[109]  I. Ferreira,et al.  Adding Molecules to Food, Pros and Cons: A Review on Synthetic and Natural Food Additives. , 2014, Comprehensive reviews in food science and food safety.

[110]  Yikai Zhou,et al.  A novel nitrite biosensor based on single-layer graphene nanoplatelet-protein composite film. , 2011, Biosensors & bioelectronics.

[111]  B. Singh,et al.  Organophosphorus-degrading bacteria: ecology and industrial applications , 2009, Nature Reviews Microbiology.

[112]  Yu Zhang,et al.  Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. , 2007, Nature nanotechnology.

[113]  J. A. Camargo,et al.  Nitrate toxicity to aquatic animals: a review with new data for freshwater invertebrates. , 2005, Chemosphere.

[114]  P. Scrimin,et al.  Nanozymes: gold-nanoparticle-based transphosphorylation catalysts. , 2004, Angewandte Chemie.

[115]  J Olley,et al.  Histamine fish poisoning revisited. , 2000, International journal of food microbiology.

[116]  Y. Yang,et al.  Oxidation activity modulation of single atom Ce-N-C nanozyme enable time-resolved sensor to detect Fe3+ and Cr6+ , 2022, Journal of Materials Chemistry C.

[117]  Chengzhou Zhu,et al.  Nanozyme Enhanced Colorimetric Immunoassay for Naked-Eye Detection of Salmonella Enteritidis , 2018, Journal of Analysis and Testing.

[118]  Aruna Jyothi Kora,et al.  Peroxidase activity of biogenic platinum nanoparticles: A colorimetric probe towards selective detection of mercuric ions in water samples , 2018 .

[119]  E. Prabakaran,et al.  Amperometric detection of Sudan I in red chili powder samples using Ag nanoparticles decorated graphene oxide modified glassy carbon electrode. , 2015, Food chemistry.

[120]  A. Mantovani,et al.  Identification and management of toxicological hazards of street foods in developing countries. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.