STAT3, stem cells, cancer stem cells and p63

[1]  David J. Arenillas,et al.  JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework , 2017, Nucleic acids research.

[2]  V. Poli,et al.  STAT3 in cancer: A double edged sword. , 2017, Cytokine.

[3]  B. Westermark,et al.  Mast cells modulate proliferation, migration and stemness of glioma cells through downregulation of GSK3β expression and inhibition of STAT3 activation. , 2017, Cellular signalling.

[4]  R. Yazdanparast,et al.  Activation of STAT3/HIF-1α/Hes-1 axis promotes trastuzumab resistance in HER2-overexpressing breast cancer cells via down-regulation of PTEN. , 2017, Biochimica et biophysica acta. General subjects.

[5]  M. Myers,et al.  STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance. , 2017, Endocrine-related cancer.

[6]  Xunbin Wei,et al.  Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea , 2017, Stem cell reports.

[7]  B. Vojtesek,et al.  ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells , 2017, Breast Cancer Research and Treatment.

[8]  Y. Xi,et al.  STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis. , 2017, Biochemical and biophysical research communications.

[9]  M. Kadakia,et al.  ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition , 2016, Oncotarget.

[10]  Mingming Jia,et al.  COSMIC: somatic cancer genetics at high-resolution , 2016, Nucleic Acids Res..

[11]  F. Kittrell,et al.  TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway , 2016, Oncogene.

[12]  K. Meldrum,et al.  Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production. , 2017, American journal of physiology. Renal physiology.

[13]  A. Lánczky,et al.  miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients , 2016, Breast Cancer Research and Treatment.

[14]  Elena Butturini,et al.  Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function. , 2016, The Biochemical journal.

[15]  Tom H. Cheung,et al.  STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. , 2016, Cell reports.

[16]  Haluk Resat,et al.  Constitutive activation of STAT3 in breast cancer cells: A review , 2016, International journal of cancer.

[17]  N. Hockstein,et al.  CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation. , 2016, Immunity.

[18]  P. Coates,et al.  ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer , 2016, Tumor Biology.

[19]  Masoud Soleimani,et al.  STAT3 is Overactivated in Gastric Cancer Stem-Like Cells , 2016, Cell journal.

[20]  Christopher J. Lyon,et al.  Cancer Stem Cells : Basic Concepts and Therapeutic Implications , 2016 .

[21]  Jiayuh Lin,et al.  Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism. , 2016, Trends in pharmacological sciences.

[22]  Jie Yuan,et al.  Multiple regulation pathways and pivotal biological functions of STAT3 in cancer , 2015, Scientific Reports.

[23]  Shiaw-Min Hwang,et al.  Bcl3 Bridges LIF‐STAT3 to Oct4 Signaling in the Maintenance of Naïve Pluripotency , 2015, Stem cells.

[24]  X. Chen,et al.  The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation , 2015, Nature Immunology.

[25]  Xin-hua Liang,et al.  Links between cancer stem cells and epithelial–mesenchymal transition , 2015, OncoTargets and therapy.

[26]  J. Meléndez-Zajgla,et al.  NF-κB signaling in cancer stem cells: a promising therapeutic target? , 2015, Cellular Oncology.

[27]  S. Thorgeirsson,et al.  Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinoma , 2015, Hepatology.

[28]  Zhongnan Cao,et al.  Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway. , 2015, American journal of translational research.

[29]  Michael Weber,et al.  Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency , 2015, Nature Communications.

[30]  B. Vojtesek,et al.  The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site. , 2015, Histology and histopathology.

[31]  Xinbing Sui,et al.  The role of STAT3 in autophagy , 2015, Autophagy.

[32]  G. Tonon,et al.  p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling , 2015, Proceedings of the National Academy of Sciences.

[33]  G. Sethi,et al.  Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel , 2015, Oncotarget.

[34]  Chengyi Sun,et al.  MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. , 2015, Cancer letters.

[35]  Guang-Yuh Chiou,et al.  Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells , 2015, Oncotarget.

[36]  S. Sinha,et al.  Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes , 2014, BMC Genomics.

[37]  Leonid Peshkin,et al.  A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis , 2014, Cell.

[38]  Jing Wang,et al.  MiR‐7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway , 2014, Stem cells.

[39]  Hua Yu,et al.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions , 2014, Nature Reviews Cancer.

[40]  S. Hilsenbeck,et al.  STAT3 Signaling Is Activated Preferentially in Tumor‐Initiating Cells in Claudin‐Low Models of Human Breast Cancer , 2014, Stem cells.

[41]  G. Stark,et al.  Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3* , 2014, The Journal of Biological Chemistry.

[42]  C. Creighton,et al.  VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2 , 2014, Oncogene.

[43]  Dino Amadori,et al.  ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling , 2014, Nature Cell Biology.

[44]  Yang Wang,et al.  IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells , 2014, Proceedings of the National Academy of Sciences.

[45]  R. Weinberg,et al.  Tackling the cancer stem cells — what challenges do they pose? , 2014, Nature Reviews Drug Discovery.

[46]  Guanyi Huang,et al.  STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates , 2014, Stem cells.

[47]  R. Carpenter,et al.  STAT3 Target Genes Relevant to Human Cancers , 2014, Cancers.

[48]  M. Pawlus,et al.  STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells , 2014, Oncogene.

[49]  Hua Yu,et al.  Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. , 2014, Cancer research.

[50]  Mozaffarul Islam,et al.  RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3 , 2014, PloS one.

[51]  H. Zou,et al.  An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. , 2014, Journal of proteomics.

[52]  G. Christofori,et al.  VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. , 2014, Cancer research.

[53]  J. Vadgama,et al.  STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits , 2013, International journal of oncology.

[54]  J. Vadgama,et al.  Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells , 2013, PloS one.

[55]  G. Stark,et al.  STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor , 2013, Proceedings of the National Academy of Sciences.

[56]  M. Geletu,et al.  Classical cadherins control survival through the gp130/Stat3 axis. , 2013, Biochimica et biophysica acta.

[57]  B. Vojtesek,et al.  Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry , 2013, Virchows Archiv.

[58]  D. Nam,et al.  Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. , 2013, Cancer cell.

[59]  Yan Geng,et al.  p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia , 2013, Proceedings of the National Academy of Sciences.

[60]  G. Parkinson,et al.  Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography , 2013, FEBS letters.

[61]  R. Mantovani,et al.  EGFR through STAT3 modulates ΔN63α expression to sustain tumor‐initiating cell proliferation in squamous cell carcinomas , 2013, Journal of cellular physiology.

[62]  Yun Lu,et al.  Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. , 2013, Cell stem cell.

[63]  Jihwan Song,et al.  PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. , 2013, International journal of oncology.

[64]  R. Xiang,et al.  Tumor‐Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox‐2 Signaling Pathway , 2013, Stem cells.

[65]  C. Watson,et al.  Stat3 Is Required to Maintain the Full Differentiation Potential of Mammary Stem Cells and the Proliferative Potential of Mammary Luminal Progenitors , 2012, PloS one.

[66]  M. Wicha,et al.  Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. , 2012, Molecular cell.

[67]  Yanjie Lu,et al.  microRNA‐124 Regulates Cardiomyocyte Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Via Targeting STAT3 Signaling , 2012, Stem cells.

[68]  T. Witzig,et al.  Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation. , 2012, Blood.

[69]  Z. Zhao,et al.  Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer , 2012, Breast Cancer Research.

[70]  Giuseppe Pelosi,et al.  p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma , 2012, Modern Pathology.

[71]  Valeriy R. Korostyshevskiy,et al.  Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA* , 2012, The Journal of Biological Chemistry.

[72]  Ying-chao Wang,et al.  Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer , 2012, Journal of Molecular Medicine.

[73]  F. Zouein,et al.  Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. , 2012, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[74]  S. Chiou,et al.  Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway. , 2012, Lung cancer.

[75]  F. Baran-Marszak,et al.  STAT 3 inhibitors for cancer therapy Have all roads been explored ? , 2012 .

[76]  S. Badve,et al.  Breast-cancer stem cells-beyond semantics. , 2012, The Lancet. Oncology.

[77]  Li Lin,et al.  STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells. , 2011, Biochemical and biophysical research communications.

[78]  Guido Gerken,et al.  Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. , 2011, Gastroenterology.

[79]  I. Amelio,et al.  The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. , 2011, Biochemical pharmacology.

[80]  Yi-Wen Chang,et al.  Direct reprogramming of stem cell properties in colon cancer cells by CD44 , 2011, The EMBO journal.

[81]  Hideaki Tahara,et al.  Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells , 2011, Proceedings of the National Academy of Sciences.

[82]  Mithat Gönen,et al.  The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. , 2011, The Journal of clinical investigation.

[83]  Chien-Chia Cheng,et al.  STAT3 regulates the proliferation and differentiation of rabbit limbal epithelial cells via a ΔNp63-dependent mechanism. , 2011, Investigative ophthalmology & visual science.

[84]  M. Wicha,et al.  Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots , 2011, Clinical Cancer Research.

[85]  N. Reich,et al.  Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-β1 , 2011, PloS one.

[86]  C. Van Waes,et al.  ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation. , 2011, Cancer research.

[87]  R. McLendon,et al.  Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. , 2011, Cancer cell.

[88]  B. Vojtesek,et al.  The role of P63 in cancer, stem cells and cancer stem cells , 2011, Cellular & Molecular Biology Letters.

[89]  D. Banerjee,et al.  Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu. , 2010, Experimental cell research.

[90]  G. Stark,et al.  Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes , 2010, Proceedings of the National Academy of Sciences.

[91]  Hua Yu,et al.  Stat3-induced S1PR1 expression is critical for persistent Stat3 activation in tumors , 2010, Nature Medicine.

[92]  Austin G Smith,et al.  Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency , 2010, Cell stem cell.

[93]  J. Settleman,et al.  EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer , 2010, Oncogene.

[94]  M. Tremblay,et al.  Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation , 2010, PLoS ONE.

[95]  Xiaomin Chen,et al.  STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. , 2010, Blood.

[96]  Ying Wang,et al.  Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. , 2010, The Journal of clinical investigation.

[97]  Z. Szallasi,et al.  An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients , 2010, Breast Cancer Research and Treatment.

[98]  H. Khatib,et al.  Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle. , 2009, Journal of dairy science.

[99]  Hua Yu,et al.  STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.

[100]  Jeong-Ho Kim,et al.  Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation* , 2009, The Journal of Biological Chemistry.

[101]  R. Weinberg,et al.  Cancer stem cells: mirage or reality? , 2009, Nature Medicine.

[102]  D. Levy,et al.  Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation , 2009, Science.

[103]  Jeffrey M. Rosen,et al.  The Increasing Complexity of the Cancer Stem Cell Paradigm , 2009, Science.

[104]  Jeou-Yuan Chen,et al.  Acetylation and activation of STAT3 mediated by nuclear translocation of CD44 , 2009, The Journal of cell biology.

[105]  David García-Dorado,et al.  TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. , 2009, Cancer cell.

[106]  Hua Yu,et al.  Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. , 2009, Cancer research.

[107]  P. Fawcett,et al.  Function of Mitochondrial Stat3 in Cellular Respiration , 2009, Science.

[108]  Debra L Winkeljohn.  Triple-negative breast cancer. , 2008, Clinical journal of oncology nursing.

[109]  R. Jove,et al.  Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas , 2008, Molecular Cancer Therapeutics.

[110]  E. Hurt,et al.  Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation. , 2008, Cancer research.

[111]  A. Puisieux,et al.  Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition , 2008, PloS one.

[112]  C. Van Waes,et al.  The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth. , 2008, Cancer research.

[113]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[114]  J. Karras,et al.  STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. , 2008, Journal of Clinical Investigation.

[115]  Jan-Kan Chen,et al.  Transcriptional Activity of the ΔNp63 Promoter Is Regulated by STAT3* , 2008, Journal of Biological Chemistry.

[116]  C. Deng,et al.  Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling , 2008, Proceedings of the National Academy of Sciences.

[117]  Fiona M. Watt,et al.  Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFκB and cooperating with Stat3 , 2008, Nature Cell Biology.

[118]  J. Margolick,et al.  Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance , 2007, Proceedings of the National Academy of Sciences.

[119]  G. Cohen,et al.  Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis , 2007, Proceedings of the National Academy of Sciences.

[120]  G. Stark,et al.  Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. , 2007, Genes & development.

[121]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[122]  Daniel J. Hoeppner,et al.  Notch signalling regulates stem cell numbers in vitro and in vivo , 2006, Nature.

[123]  C. Eaves,et al.  Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration. , 2006, Blood.

[124]  S. Flamant,et al.  BCR–ABL activates STAT3 via JAK and MEK pathways in human cells , 2006, British journal of haematology.

[125]  S. Akira,et al.  Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex , 2006, Development.

[126]  Jan-Kan Chen,et al.  Dual regulation of the DeltaNp63 transcriptional activity by DeltaNp63 in human nasopharyngeal carcinoma cell. , 2006, Biochemical and biophysical research communications.

[127]  L. D. White,et al.  Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. , 2006, Cancer research.

[128]  S. Pelech,et al.  Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest. , 2006, Biochemistry.

[129]  S. Sebti,et al.  Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. , 2005, Cancer research.

[130]  Y. Hanakawa,et al.  Suppression of Stat3 promotes neurogenesis in cultured neural stem cells , 2005, Journal of neuroscience research.

[131]  Kevin M. McBride,et al.  STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[132]  Jianyuan Luo,et al.  Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation* , 2005, Journal of Biological Chemistry.

[133]  S. Dalton,et al.  LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism , 2005, Development.

[134]  D. Levy,et al.  Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. , 2005, Cancer research.

[135]  Y. E. Chin,et al.  Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue , 2005, Science.

[136]  J. Rush,et al.  Immunoaffinity profiling of tyrosine phosphorylation in cancer cells , 2005, Nature Biotechnology.

[137]  Holm Zaehres,et al.  LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells , 2004, Stem cells.

[138]  H. Kutsuna,et al.  Proteolytic Conversion of STAT3α to STAT3γ in Human Neutrophils , 2004, Journal of Biological Chemistry.

[139]  Ana D. Lopez,et al.  Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent , 2004, Stem cells.

[140]  M. Nakafuku,et al.  Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling , 2004, Nature Cell Biology.

[141]  M. Hino,et al.  Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-alpha production. , 2004, American journal of physiology. Cell physiology.

[142]  S. Dewilde,et al.  The STAT3 isoforms alpha and beta have unique and specific functions. , 2004, Nature immunology.

[143]  H. Kutsuna,et al.  Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. , 2004, The Journal of biological chemistry.

[144]  Cathy H. Wu,et al.  UniProt: the Universal Protein knowledgebase , 2004, Nucleic Acids Res..

[145]  J. Karras,et al.  macrophage survival Serine phosphorylation of STAT 3 is essential for Mcl-1 expression and , 2003 .

[146]  J. S. Gutkind,et al.  Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. , 2003, Cancer research.

[147]  D. Burstein,et al.  p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung. , 2003, American journal of clinical pathology.

[148]  R. Nenutil,et al.  Differential expression of p63 isoforms in normal tissues and neoplastic cells , 2002, The Journal of pathology.

[149]  T. Smithgall,et al.  Activation of STAT3 by the Src Family Kinase Hck Requires a Functional SH3 Domain* , 2002, The Journal of Biological Chemistry.

[150]  J. Pow-Sang,et al.  Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. , 2002, Cancer research.

[151]  J. Darnell,et al.  Signalling: STATs: transcriptional control and biological impact , 2002, Nature Reviews Molecular Cell Biology.

[152]  M. Masuda,et al.  Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. , 2002, Cancer research.

[153]  Y. Matsumura,et al.  TAp63γ (p51A) and dNp63α (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression , 2002, Oncogene.

[154]  R. Jove,et al.  Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[155]  E. Papoutsakis,et al.  Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. , 2002, Blood.

[156]  Yusuke Nakamura,et al.  The p53 Family Member Genes Are Involved in the Notch Signal Pathway* , 2002, The Journal of Biological Chemistry.

[157]  Y. Matsumura,et al.  TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression. , 2002, Oncogene.

[158]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[159]  D. Ponzin,et al.  p63 identifies keratinocyte stem cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[160]  J. G. Zhang,et al.  Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[161]  S. Wiegand,et al.  Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia , 2000, The Journal of Neuroscience.

[162]  D. Levy,et al.  Mechanism of STAT3 Activation by Insulin-like Growth Factor I Receptor* , 2000, The Journal of Biological Chemistry.

[163]  J. Turkson,et al.  Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein , 1999, Molecular and Cellular Biology.

[164]  Xinmin Cao,et al.  Serine Phosphorylation and Negative Regulation of Stat3 by JNK* , 1999, The Journal of Biological Chemistry.

[165]  T. Decker,et al.  Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins , 1999, Cellular and Molecular Life Sciences CMLS.

[166]  Tong Zhang,et al.  Protein Kinase C δ Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner* , 1999, The Journal of Biological Chemistry.

[167]  M. Katsuki,et al.  STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells , 1999, The EMBO journal.

[168]  K. Nakashima,et al.  STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M , 1999, Neuroscience Letters.

[169]  Christopher P. Crum,et al.  p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development , 1999, Nature.

[170]  H. Vogel,et al.  p63 is a p53 homologue required for limb and epidermal morphogenesis , 1999, Nature.

[171]  P. D’Eustachio,et al.  Essential role of STAT3 for embryonic stem cell pluripotency. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[172]  A. Yang,et al.  p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. , 1998, Molecular cell.

[173]  J. Ritz,et al.  B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. , 1997, The Journal of clinical investigation.

[174]  P Jay,et al.  Specific inhibition of Stat3 signal transduction by PIAS3. , 1997, Science.

[175]  J. Blenis,et al.  STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation , 1997, Molecular and cellular biology.

[176]  T. Decker,et al.  GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. , 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[177]  Y. Fujio,et al.  Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. , 1996, Circulation.

[178]  J. Lammers,et al.  STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription* , 1996, The Journal of Biological Chemistry.

[179]  M. Vignais,et al.  Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins , 1996, Molecular and cellular biology.

[180]  L. Sanders,et al.  Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[181]  J. Darnell,et al.  Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation , 1995, Cell.

[182]  J. Blenis,et al.  Requirement of serine phosphorylation for formation of STAT-promoter complexes. , 1995, Science.

[183]  J. Darnell,et al.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.

[184]  J. Darnell,et al.  Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. , 1994, Science.

[185]  G. Yancopoulos,et al.  LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. , 1993, Science.