Dendrobium candidum polysaccharide reduce atopic dermatitis symptoms and modulate gut microbiota in DNFB-induced AD-like mice

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence worldwide. Increasing evidence suggests that the gut microbiota plays an important role in the pathogenesis of AD. In this study, we sought to verify the effect of Dendrobium candidum polysaccharides (DCP) on AD induced by 2,4-Dinitrofluorobenzene (DNFB) in Balb/c mice regarding its impact on the intestinal microbiome. We found that 2-week oral administration of DCP improved AD-like symptoms and histological damage of skin, reduced mast cell infiltration, down-regulated the level of serum total IgE and the expression of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-4 and IL-6, and increased the expression level of anti-inflammatory cytokine IL-10. The beneficial effect of DCP was attributed to the restoration of the intestinal microbiome composition and the unbalance of the intestinal homeostasis. Our results indicated that DCP might be used as a promising novel microbiota-modulating agent for the treatment of AD.

[1]  C. Nicco,et al.  Microbiota medicine: towards clinical revolution , 2022, Journal of translational medicine.

[2]  K. Rothman,et al.  Long-Term Risk of Skin Cancer and Lymphoma in Users of Topical Tacrolimus and Pimecrolimus: Final Results from the Extension of the Cohort Study Protopic Joint European Longitudinal Lymphoma and Skin Cancer Evaluation (JOELLE) , 2021, Clinical epidemiology.

[3]  So-Yeon Park,et al.  Efficacy of Dendrobium candidum polysaccharide extract as a moisturizer , 2021, Journal of cosmetic dermatology.

[4]  Snehal S. Patel,et al.  Sarsasapogenin and fluticasone combination improves DNFB induced atopic dermatitis lesions in BALB/c mice , 2021, Immunopharmacology and immunotoxicology.

[5]  Liang Zhou,et al.  Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients , 2021, Frontiers in Endocrinology.

[6]  Yue-Hu Wang.  Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review , 2021, Natural Products and Bioprospecting.

[7]  M. Trzeciak,et al.  Molecular Mechanisms of Atopic Dermatitis Pathogenesis , 2021, International journal of molecular sciences.

[8]  D. Hahm,et al.  Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis , 2021, International journal of molecular sciences.

[9]  Xiuqi Zhang,et al.  Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism. , 2021, International journal of biological macromolecules.

[10]  B. Paetzold,et al.  Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions , 2021, Microorganisms.

[11]  You-jin Jang,et al.  Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota , 2020, Gut microbes.

[12]  T. Grzybowski,et al.  The microbiome and its impact on food allergy and atopic dermatitis in children , 2020, Postepy dermatologii i alergologii.

[13]  Fenggen Yan,et al.  Diversity analysis of gut microbiota between healthy controls and those with atopic dermatitis in a Chinese population , 2020, The Journal of dermatology.

[14]  H. Dopazo,et al.  Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index , 2020, Scientific Reports.

[15]  Jiachao Zhang,et al.  Polyphenols in the Fermentation Liquid of Dendrobium candidum Relieve Intestinal Inflammation in Zebrafish Through the Intestinal Microbiome-Mediated Immune Response , 2020, Frontiers in Immunology.

[16]  M. Blaser,et al.  Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis , 2020, Frontiers in Cellular and Infection Microbiology.

[17]  Yingge Zhang,et al.  Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis , 2020, Evidence-based complementary and alternative medicine : eCAM.

[18]  Chunyan Hou,et al.  An insight into anti-inflammatory effects of natural polysaccharides. , 2020, International journal of biological macromolecules.

[19]  R. Sartor,et al.  Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases , 2020, Digestive Diseases and Sciences.

[20]  Ying-wu Wang,et al.  The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer , 2019, Aging.

[21]  T. Torres,et al.  Update on Atopic Dermatitis. , 2019, Acta medica portuguesa.

[22]  X-M Shao,et al.  Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt/β-catenin signaling pathway. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[23]  M. Czarnecka,et al.  Epidemiology of atopic dermatitis in Europe , 2019, Journal of drug assessment.

[24]  Lin Dong,et al.  Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells. , 2018, Gene.

[25]  S. Ng,et al.  The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease , 2018, Front. Microbiol..

[26]  S. Won,et al.  Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type , 2018, The Journal of allergy and clinical immunology.

[27]  Yoon Mee Park,et al.  Microbiome in the Gut-Skin Axis in Atopic Dermatitis , 2018, Allergy, asthma & immunology research.

[28]  S. Kersten,et al.  Potential mediators linking gut bacteria to metabolic health: a critical view , 2016, The Journal of physiology.

[29]  Eric A. Franzosa,et al.  Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity , 2016, Cell.

[30]  J. C. Jaworski,et al.  Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis , 2016, BMC Pediatrics.

[31]  K. Honda,et al.  Development and maintenance of intestinal regulatory T cells , 2016, Nature Reviews Immunology.

[32]  Stephan Weidinger,et al.  Atopic dermatitis , 2016, The Lancet.

[33]  S. C. Sze,et al.  Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology in Dendrobium Plants , 2015, Evidence-based complementary and alternative medicine : eCAM.

[34]  H. Dan,et al.  Interferon-γ and interleukin-4 detected in serum and saliva from patients with oral lichen planus , 2013, International Journal of Oral Science.

[35]  Xiaoyong Wei,et al.  [Experimental study on Dendrobium candidum polysaccharides on promotion of hair growth]. , 2014, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[36]  M. Curini,et al.  Antigenotoxic effect, composition and antioxidant activity of Dendrobium speciosum. , 2013, Food chemistry.

[37]  Gun-Dong Kim,et al.  The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC/Nga mice. , 2013, Life sciences.

[38]  W. Laleman,et al.  Desulfovibrio desulfuricans Bacteremia in an Immunocompromised Host with a Liver Graft and Ulcerative Colitis , 2011, Journal of Clinical Microbiology.

[39]  Fu-Tong Liu,et al.  IgE, Mast Cells, and Eosinophils in Atopic Dermatitis , 2011, Clinical reviews in allergy & immunology.

[40]  T. Kawakami,et al.  Mast cells in atopic dermatitis. , 2009, Current opinion in immunology.

[41]  D. Pariser.  Topical corticosteroids and topical calcineurin inhibitors in the treatment of atopic dermatitis: focus on percutaneous absorption. , 2009, American journal of therapeutics.

[42]  Jeong-Chae Lee,et al.  Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl. , 2007, Journal of biochemistry and molecular biology.

[43]  S. Tedelind,et al.  Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. , 2007, World journal of gastroenterology.

[44]  F. Shanahan,et al.  The gut flora as a forgotten organ , 2006, EMBO reports.