LIPID LOWERING ACTIVITY OF THE FRUIT JUICE OF HIPPOPHAE RHAMNOIDES L . ( SEABUCKTHORN ) IN HYPERLIPIDEMIC MODELS OF WISTAR ALBINO RATS

Lipid lowering effect of fruit juice of Hippohae rhamnoides L. was evaluated in triton and diet induced hyperlipidaemic models of wistar albino rats. The juice at 0.3 and 0.5ml/kg body weight inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The fruit juice at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidaemic rats. The standard dose atrovastatin in the former and gemfibrozil in the later studies showed slightly better effects.