Nanostructured microsphere coated with living cells and tethered with low-stiffness wire: A possible solution to brain tissue reactions

The long term stability of the interface between neural tissue and implanted microelectrodes is very important both for research and clinical purposes. To address this challenge we developed a probe composed by an ultrathin and ultra-flexible wire as tether and a low- impedance gold sphere microelectrode as recording/stimulation site. We further improved the microsphere performance using PEDOT-CNT composite coating and we mimic the biological composition of the host tissue by coating the probe with fibroblast cells.

[1]  David C. Martin,et al.  Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes. , 2008, Biomaterials.

[2]  Nicholas G Hatsopoulos,et al.  The science of neural interface systems. , 2009, Annual review of neuroscience.

[3]  Matthias Dümpelmann,et al.  3D source localization derived from subdural strip and grid electrodes: A simulation study , 2009, Clinical Neurophysiology.

[4]  P. Tresco,et al.  Response of brain tissue to chronically implanted neural electrodes , 2005, Journal of Neuroscience Methods.

[5]  Luciano Fadiga,et al.  Smaller, softer, lower-impedance electrodes for human neuroprosthesis: a pragmatic approach , 2014, Front. Neuroeng..

[6]  P. Kennedy,et al.  Restoration of neural output from a paralyzed patient by a direct brain connection , 1998, Neuroreport.

[7]  Ravi V. Bellamkonda,et al.  Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes , 2007, Brain Research.

[8]  André Mercanzini,et al.  Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[9]  C. Marin,et al.  Biocompatibility of Intracortical Microelectrodes: Current Status and Future Prospects , 2010, Front. Neuroeng..

[10]  C. Wilkinson,et al.  Nanomaterials for neural interfaces: emerging new function and potential applications , 2009 .

[11]  Gordon G. Wallace,et al.  Controlled delivery for neuro-bionic devices. , 2013, Advanced drug delivery reviews.

[12]  Luciano Fadiga,et al.  Chemical vapour deposited carbon nanotube coated microelectrodes for intracortical neural recording , 2010 .

[13]  J. Schouenborg,et al.  Gelatine-embedded electrodes—a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes , 2010, Journal of neural engineering.

[14]  Ravi V. Bellamkonda,et al.  Controlled release of anti-inflammatory agent alpha-MSH from neural implants. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[15]  L. Fadiga,et al.  PEDOT-CNT-Coated Low-Impedance, Ultra-Flexible, and Brain-Conformable Micro-ECoG Arrays , 2015, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[16]  Luciano Fadiga,et al.  Bio-inspired hybrid microelectrodes: a hybrid solution to improve long-term performance of chronic intracortical implants , 2014, Front. Neuroeng..

[17]  R L Alterman,et al.  Surgical options in Parkinson's disease. , 1999, The Medical clinics of North America.

[18]  J. Milton,et al.  Identification of the sensory/motor area and pathologic regions using ECoG coherence. , 1998, Electroencephalography and clinical neurophysiology.

[19]  Luciano Fadiga,et al.  Biologically compatible neural interface to safely couple nanocoated electrodes to the surface of the brain. , 2013, ACS nano.

[20]  J. Hetke,et al.  Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. , 2001, Journal of biomedical materials research.