Mimicking Posttranslational Modifications of Proteins

Strategies for the synthesis of pure posttranslationally modified proteins or their mimics (for example, glycosylation or prenylation) have been recently developed. In his Perspective, [Davis][1] discusses how these strategies are allowing the creation of useful biomolecular probes and how they may offer a potential route to new protein pharmaceuticals. [1]: http://www.sciencemag.org/cgi/content/full/303/5657/480

[1]  Peter G Schultz,et al.  A method for the generation of glycoprotein mimetics. , 2003, Journal of the American Chemical Society.

[2]  J. Marth,et al.  A genetic approach to Mammalian glycan function. , 2003, Annual review of biochemistry.

[3]  J. B. Jones,et al.  Controlled site-selective protein glycosylation for precise glycan structure-catalytic activity relationships. , 2000, Bioorganic & medicinal chemistry.

[4]  Peter D. Kwong,et al.  HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites , 2002, Nature.

[5]  D. Lane,et al.  Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner (*) , 1995, Journal of Biological Chemistry.

[6]  R. Lefkowitz,et al.  G protein-coupled receptor kinases. , 1998, Annual review of biochemistry.

[7]  J. Adamson,et al.  Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein , 2003, Science.

[8]  Herbert Waldmann,et al.  Bioorganic synthesis of lipid-modified proteins for the study of signal transduction , 2000, Nature.

[9]  A. Haselbeck.  Epoetins: differences and their relevance to immunogenicity , 2003, Current medical research and opinion.

[10]  Byung-Kwon Choi,et al.  Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Carolyn R Bertozzi,et al.  A chemical approach for identifying O-GlcNAc-modified proteins in cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Bertozzi,et al.  Cell surface engineering by a modified Staudinger reaction. , 2000, Science.

[13]  P G Schultz,et al.  Expanding the Genetic Code of Escherichia coli , 2001, Science.