Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype.

[1]  S. Marsch,et al.  Lethal Autoimmune Myocarditis in Interferon-&ggr; Receptor–Deficient Mice: Enhanced Disease Severity by Impaired Inducible Nitric Oxide Synthase Induction , 2001, Circulation.

[2]  J. Harty,et al.  Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. , 2000, Science.

[3]  S. Hill,et al.  Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice. , 2000, Journal of the American College of Cardiology.

[4]  A. Billiau,et al.  The protective effect of IFN‐γ in experimental autoimmune diseases: a central role of mycobacterial adjuvant‐induced myelopoiesis , 2000, Journal of leukocyte biology.

[5]  G. Peltz,et al.  Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma , 2000, Nature Immunology.

[6]  S. Wittmer,et al.  Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis , 2000, The Journal of experimental medicine.

[7]  S. Wittmer,et al.  Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells , 2000, The Journal of experimental medicine.

[8]  R. Hruban,et al.  Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. , 2000, The New England journal of medicine.

[9]  B. Strauer,et al.  Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis. , 2000, Journal of the American College of Cardiology.

[10]  V. Casolaro,et al.  Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells , 1999, The Journal of Immunology.

[11]  P. Barnes Therapeutic strategies for allergic diseases , 1999, Nature.

[12]  P. Kubes,et al.  Molecular Mechanisms Underlying IL-4-Induced Leukocyte Recruitment In Vivo: A Critical Role for the α4 Integrin , 1999, The Journal of Immunology.

[13]  A. Ohta,et al.  Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo , 1999, The Journal of experimental medicine.

[14]  P. Björck Development of dendritic cells and their use in tumor therapy. , 1999, Clinical immunology.

[15]  N. Sarvetnick,et al.  Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. , 1999, Journal of immunology.

[16]  G. McKenzie,et al.  Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses , 1999, The Journal of experimental medicine.

[17]  S. Hill,et al.  Characterization of murine autoimmune myocarditis induced by self and foreign cardiac myosin. , 1999, Autoimmunity.

[18]  V. Casolaro,et al.  Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells. , 1999, Journal of immunology.

[19]  W. Paul,et al.  The IL-4 receptor: signaling mechanisms and biologic functions. , 1999, Annual review of immunology.

[20]  W. Strober,et al.  Oxazolone Colitis: A Murine Model of  T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4 , 1998, The Journal of experimental medicine.

[21]  T. K. van den Berg,et al.  Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16). , 1998, Journal of immunology.

[22]  R. Caspi,et al.  IL-12 in autoimmunity. , 1998, Clinical immunology and immunopathology.

[23]  J. Stavnezer,et al.  Interaction of Stat6 and NF-κB: Direct Association and Synergistic Activation of Interleukin-4-Induced Transcription , 1998, Molecular and Cellular Biology.

[24]  M. Kodama,et al.  Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats. , 1998, Circulation research.

[25]  J. D. de Vries The role of IL-13 and its receptor in allergy and inflammatory responses. , 1998, The Journal of allergy and clinical immunology.

[26]  J. McQuillan,et al.  TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells. , 1997, Journal of immunology.

[27]  S. Tonegawa,et al.  Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease , 1997, The Journal of experimental medicine.

[28]  M. Kurrer,et al.  T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice , 1997, The Journal of experimental medicine.

[29]  A. Billiau,et al.  Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. , 1997, Journal of immunology.

[30]  E. Rakasz,et al.  Lack of Fc-e Receptors on Murine Eosinophils: Implications for the Functional Significance of Elevated IgE and Eosinophils in Parasitic Infections , 1997 .

[31]  G. Nolan,et al.  Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis , 1997, The Journal of experimental medicine.

[32]  G. Marone,et al.  Eosinophil granule proteins are selective activators of human heart mast cells. , 1997, International archives of allergy and immunology.

[33]  S. Huber Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[34]  B. Bloom,et al.  A T Helper Cell 2 (Th2) Immune Response against Non-self Antigens Modifies the Cytokine Profile of Autoimmune T Cells and Protects against Experimental Allergic Encephalomyelitis , 1997, The Journal of experimental medicine.

[35]  T. Mak,et al.  Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. , 1997, Circulation.

[36]  U. Boehm,et al.  Cellular responses to interferon-gamma. , 1997, Annual review of immunology.

[37]  E. Rakasz,et al.  Lack of Fc-epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infections. , 1997, Blood.

[38]  S. Bayrak,et al.  Protective major histocompatibility complex genes and the role of interleukin‐4 in collagen‐induced arthritis , 1996, European journal of immunology.

[39]  H. Kita,et al.  Eosinophil viability during immunoglobulin‐induced degranulation , 1996, Journal of leukocyte biology.

[40]  B. Bellon,et al.  Recombinant IL-4 aggravates experimental autoimmune uveoretinitis in rats. , 1996, Journal of Immunology.

[41]  G. Marone,et al.  Eosinophil granule proteins activate human heart mast cells. , 1996, Journal of immunology.

[42]  P. Gleeson,et al.  Interferon‐γ is required during the initiation of an organ‐specific autoimmune disease , 1996 .

[43]  W. Mckenna,et al.  Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives. , 1996, International journal of cardiology.

[44]  T. Mosmann,et al.  The expanding universe of T-cell subsets: Th1, Th2 and more. , 1996, Immunology today.

[45]  F. Brombacher,et al.  Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice , 1995, Immunological reviews.

[46]  J. Anderson,et al.  Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. , 1995, The American journal of pathology.

[47]  K. Beisel,et al.  Myocarditis-inducing epitope of myosin binds constitutively and stably to I-Ak on antigen-presenting cells in the heart , 1995, The Journal of experimental medicine.

[48]  J. O’Connell,et al.  Myocarditis and idiopathic dilated cardiomyopathy , 1995, The American Journal of Medicine.

[49]  B. McManus,et al.  A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. , 1995, The New England journal of medicine.

[50]  R. Coffman,et al.  Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. , 1995, Science.

[51]  C Benoist,et al.  T helper cell subsets in insulin-dependent diabetes. , 1995, Science.

[52]  L. Leinwand,et al.  Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity , 1995, The Journal of experimental medicine.

[53]  H. Mcdevitt,et al.  Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. , 1995, Immunology today.

[54]  D. Dean,et al.  Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells. , 1995, The Journal of clinical investigation.

[55]  W. B. van den Berg,et al.  Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis. , 1994, Immunology.

[56]  P. Morris,et al.  Isolation and characterization of dendritic cells from mouse heart and kidney. , 1994, Journal of immunology.

[57]  A. Billiau,et al.  Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. , 1994, Journal of immunology.

[58]  C. Czuprynski,et al.  Analysis of cytokine mRNA expression in Listeria-resistant C57BL/6 and Listeria-susceptible A/J mice during Listeria monocytogenes infection , 1993, Infection and immunity.

[59]  H. Nakajima,et al.  Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells , 1993, The Journal of experimental medicine.

[60]  P. Meroni,et al.  The effects of a monoclonal antibody to interferon‐γ on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT‐specific T cells , 1993, European journal of immunology.

[61]  R. Knobler,et al.  Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis. , 1993, Autoimmunity.

[62]  P. Leder,et al.  An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. , 1992, Science.

[63]  P. Allen,et al.  Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis. , 1992, Circulation research.

[64]  A. Herskowitz,et al.  Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice , 1992, The Journal of experimental medicine.

[65]  E. Fisman,et al.  Sudden unexpected death in persons <40 years of age , 1991 .

[66]  P. Allen,et al.  Myosin-induced acute myocarditis is a T cell-mediated disease. , 1991, Journal of immunology.

[67]  J. Albina,et al.  Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. , 1991, Journal of immunology.

[68]  E. Fisman,et al.  Sudden unexpected death in persons less than 40 years of age. , 1991, The American journal of cardiology.

[69]  C. Janeway,et al.  Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance , 1990, The Journal of experimental medicine.

[70]  N. Sarvetnick,et al.  Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ , 1990, Nature.

[71]  N. Sarvetnick,et al.  Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. , 1990, Nature.

[72]  R. Coffman,et al.  Lymphokine control of in vivo immunoglobulin isotype selection. , 1990, Annual review of immunology.

[73]  E. Sercarz,et al.  Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. , 1989, Cellular immunology.

[74]  R. Coffman,et al.  Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. , 1989, Science.

[75]  P. Leder,et al.  Murine interleukin-4 displays potent anti-tumor activity in vivo , 1989, Cell.

[76]  R. Graziano,et al.  Fc gamma R-mediated killing by eosinophils. , 1989, Journal of immunology.

[77]  T. Gajewski,et al.  Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. , 1988, Journal of immunology.

[78]  D. Rennick,et al.  Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells , 1988, The Journal of experimental medicine.

[79]  K. Beisel,et al.  Cardiac myosin induces myocarditis in genetically predisposed mice. , 1987, Journal of immunology.

[80]  W. Paul,et al.  Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1 , 1985, The Journal of experimental medicine.

[81]  N. Alpert,et al.  Purification of cardiac myosin. Application to hypertrophied myocardium. , 1975, Biochimica et biophysica acta.