Vagus nerve modulation using focused pulsed ultrasound: Potential applications and preliminary observations in a rat

The use of focused ultrasonic waves to modulate neural structures has gained recent interest due to its potential in treating neurological disorders noninvasively. While several articles have focused on the use of ultrasound neuromodulation on peripheral nerves, none of these studies have been performed on the vagus nerve. We present preliminary observations on the effects of focused pulsed ultrasound (FPUS) on the conduction of the left cervical vagus nerve of a Long Evans rat. Ultrasound energy was applied at a frequency of 1.1 MHz, and at spatial‐peak, temporal average intensities that ranged from 13.6 to 93.4 W/cm2. Vagus nerve inhibition was observed in most cases. Results of this preliminary study suggested that there is a proportional relationship between acoustic intensity and the level of nerve inhibition.

[1]  W. Newsome,et al.  Effective parameters for ultrasound-induced in vivo neurostimulation. , 2013, Ultrasound in medicine & biology.

[2]  Thomas R. Henry,et al.  Therapeutic mechanisms of vagus nerve stimulation , 2002, Neurology.

[3]  Byoung-Kyong Min,et al.  Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity , 2011, BMC Neuroscience.

[4]  Byoung-Kyong Min,et al.  Focused ultrasound modulates the level of cortical neurotransmitters: Potential as a new functional brain mapping technique , 2011, Int. J. Imaging Syst. Technol..

[5]  L. R. Gavrilov,et al.  Focused ultrasound as a tool to input sensory information to humans (Review) , 2012 .

[6]  Govert Hoogland,et al.  Animal models for vagus nerve stimulation in epilepsy , 2011, Experimental Neurology.

[7]  K. Hynynen,et al.  Focused ultrasound effects on nerve action potential in vitro. , 2009, Ultrasound in medicine & biology.

[8]  Amit P. Mulgaonkar,et al.  A review of low-intensity focused ultrasound pulsation , 2011, Brain Stimulation.

[9]  S. Tillery,et al.  Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits , 2010, Neuron.

[10]  A. Milby,et al.  Vagus nerve stimulation for epilepsy and depression , 2011, Neurotherapeutics.

[11]  Vesna Zderic,et al.  Mechanical bioeffects of pulsed high intensity focused ultrasound on a simple neural model. , 2012, Medical physics.

[12]  E Stålberg,et al.  Changes in motor and sensory nerve conduction parameters with temperature in normal and diseased nerve. , 1992, Electroencephalography and clinical neurophysiology.

[13]  Yusuf Tufail,et al.  Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound , 2008, PloS one.

[14]  P. Tsui,et al.  In vitro effects of ultrasound with different energies on the conduction properties of neural tissue. , 2005, Ultrasonics.

[15]  S. Yoo,et al.  Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound. , 2012, Ultrasound in medicine & biology.