Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion.

[1]  J. Lissitzky,et al.  MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration. , 2009, Matrix biology : journal of the International Society for Matrix Biology.

[2]  M. Cominetti,et al.  The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: insights for a new classification of snake venom metalloprotease subgroups. , 2008, Toxicon : official journal of the International Society on Toxinology.

[3]  J. Fox,et al.  Activation of leukocyte rolling by the cysteine‐rich domain and the hyper‐variable region of HF3, a snake venom hemorrhagic metalloproteinase , 2008, FEBS letters.

[4]  J. Calvete,et al.  Evolution of snake venom disintegrins by positive Darwinian selection. , 2008, Molecular biology and evolution.

[5]  J. Fox,et al.  Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity , 2008, The FEBS journal.

[6]  A. Parker,et al.  Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. , 2007, Journal of molecular biology.

[7]  N. Wang,et al.  Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761. , 2007, Investigative ophthalmology & visual science.

[8]  J. Fox,et al.  Interaction of the cysteine‐rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site‐specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor‐mediated platelet aggregation , 2007, The FEBS journal.

[9]  J. Rosa,et al.  Molecular characterization and phylogenetic analysis of BjussuMP-I: a RGD-P-III class hemorrhagic metalloprotease from Bothrops jararacussu snake venom. , 2007, Journal of molecular graphics & modelling.

[10]  S. Takeda,et al.  Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins , 2007, FEBS letters.

[11]  José Luis,et al.  Lebectin and lebecetin, two C-type lectins from snake venom, inhibit α5β1 and αv-containing integrins ☆ , 2007 .

[12]  Deyu Wang,et al.  The Cysteine-rich Domain of Snake Venom Metalloproteinases Is a Ligand for von Willebrand Factor A Domains , 2006, Journal of Biological Chemistry.

[13]  C. Bon,et al.  Molecular diversity of disintegrin-like domains within metalloproteinase precursors of Bothrops jararaca. , 2006, Toxicon : official journal of the International Society on Toxinology.

[14]  S. Takeda,et al.  Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C‐shaped scaffold , 2006, The EMBO journal.

[15]  S. Wagstaff,et al.  Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom , 2006, PLoS medicine.

[16]  J. Calvete,et al.  Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system. , 2006, The Biochemical journal.

[17]  H. Selistre‐de‐Araujo,et al.  Snake venom metalloproteases--structure and function of catalytic and disintegrin domains. , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[18]  Silvio C. E. Tosatto,et al.  The Victor/FRST Function for Model Quality Estimation , 2005, J. Comput. Biol..

[19]  Sabatier Jean-Marc,et al.  Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis , 2005, Laboratory Investigation.

[20]  Deyu Wang,et al.  Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor. , 2005, The Biochemical journal.

[21]  J. Calvete,et al.  Snake venom disintegrins: evolution of structure and function. , 2005, Toxicon : official journal of the International Society on Toxinology.

[22]  Horst Kessler,et al.  Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD , 2005, PLoS medicine.

[23]  J. Calvete Structure-function correlations of snake venom disintegrins. , 2005, Current pharmaceutical design.

[24]  J. Calvete,et al.  Lebectin, a novel C-type lectin from Macrovipera lebetina venom, inhibits integrin-mediated adhesion, migration and invasion of human tumour cells , 2004, Laboratory Investigation.

[25]  Cristina H. B. Terruggi,et al.  Alternagin-C, a Disintegrin-like Protein, Induces Vascular Endothelial Cell Growth Factor (VEGF) Expression and Endothelial Cell Proliferation in Vitro* , 2004, Journal of Biological Chemistry.

[26]  J. Fox,et al.  BaG, a new dimeric metalloproteinase/disintegrin from the Bothrops alternatus snake venom that interacts with α5β1 integrin , 2003 .

[27]  J. Fox,et al.  Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability. , 2003, Archives of biochemistry and biophysics.

[28]  J. Fox,et al.  The Reprolysin Jararhagin, a Snake Venom Metalloproteinase, Functions as a Fibrillar Collagen Agonist Involved in Fibroblast Cell Adhesion and Signaling* , 2002, The Journal of Biological Chemistry.

[29]  Tomoko Takahashi,et al.  Molecular cloning of HR1a and HR1b, high molecular hemorrhagic factors, from Trimeresurus flavoviridis venom. , 2002, Toxicon : official journal of the International Society on Toxinology.

[30]  I. Campbell,et al.  Developmental Regulation of β1 Integrins during Angiogenesis in the Central Nervous System , 2002, Molecular and Cellular Neuroscience.

[31]  K. Pienta,et al.  The role of alpha(v)beta(3) in prostate cancer progression. , 2002, Neoplasia.

[32]  A. Montgomery,et al.  Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. , 2001, Molecular biology of the cell.

[33]  P. Speight,et al.  αvβ6integrin promotes invasion of squamous carcinoma cells through up‐regulation of matrix metalloproteinase‐9 , 2001 .

[34]  A. Moura-da-Silva,et al.  Selective Recognition of α2β1 Integrin by Jararhagin, a Metalloproteinase/Disintegrin from Bothrops jararaca Venom , 2001 .

[35]  K. Titani,et al.  Complete amino acid sequence of kaouthiagin, a novel cobra venom metalloproteinase with two disintegrin-like sequences. , 2001, Biochemistry.

[36]  R. Zingali,et al.  The Disintegrin-like Domain of the Snake Venom Metalloprotease Alternagin Inhibits α2β1 Integrin-Mediated Cell Adhesion , 2000 .

[37]  Xiaodong Feng,et al.  Angiogenesis in wound healing. , 2000, The journal of investigative dermatology. Symposium proceedings.

[38]  X. Wu,et al.  Purification, characterization, and cDNA sequence of halysetin, a disintegrin-like/cysteine-rich protein from the venom of Agkistrodon halys Pallas. , 2000, Biochemical and biophysical research communications.

[39]  J. Kreidberg,et al.  Integrins in kidney development, function, and disease. , 2000, American journal of physiology. Renal physiology.

[40]  S. Vijay-Kumar,et al.  Viper Venom Disintegrins and Related Molecules , 1998, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[41]  C. Ownby,et al.  Analysis of a cDNA sequence encoding a novel member of the snake venom metalloproteinase, disintegrin-like, cysteine-rich (MDC) protein family from Agkistrodon contortrix laticinctus. , 1997, Biochimica et biophysica acta.

[42]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[43]  J. Fox,et al.  Sequence and biological activity of catrocollastatin-C: a disintegrin-like/cysteine-rich two-domain protein from Crotalus atrox venom. , 1997, Archives of biochemistry and biophysics.

[44]  J. Fox,et al.  Function of Disintegrin-like/Cysteine-rich Domains of Atrolysin A , 1997, The Journal of Biological Chemistry.

[45]  G J Kleywegt,et al.  Phi/psi-chology: Ramachandran revisited. , 1996, Structure.

[46]  Chandra L. Theesfeld,et al.  Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[47]  David A. Cheresh,et al.  Definition of Two Angiogenic Pathways by Distinct αv Integrins , 1995, Science.

[48]  K. Aldape,et al.  Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. , 1995, Journal of cell science.

[49]  Q. Zhou,et al.  Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (western diamondback rattlesnake) which inhibits platelet adhesion to collagen. , 1995, The Biochemical journal.

[50]  M. Paine,et al.  Cloning of Metalloprotease Genes in the Carpet Viper (Echis pyramidurm leakeyi) , 1994 .

[51]  K. Titani,et al.  A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation. , 1994, Biochemical and biophysical research communications.

[52]  D. Cheresh,et al.  Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.

[53]  V. Quaranta,et al.  A Monoclonal Antibody Inhibits Adhesion to Fibronectin and Vitronectin of a Colon Carcinoma Cell Line and Recognizes the Integrins αvβ3, αvβ5, and αvβ6 , 1994 .

[54]  M Karplus,et al.  Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan binding regions and protease-specific antigenic epitopes. , 1993, The Journal of biological chemistry.

[55]  S. Iwanaga,et al.  Primary structures of platelet aggregation inhibitors (disintegrins) autoproteolytically released from snake venom hemorrhagic metalloproteinases and new fluorogenic peptide substrates for these enzymes. , 1993, Journal of biochemistry.

[56]  M. Schwartz,et al.  Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms , 1993, The Journal of cell biology.

[57]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[58]  R. Kini,et al.  Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor. , 1992, Toxicon : official journal of the International Society on Toxinology.

[59]  M. Hayashi,et al.  Novel purification of vitronectin from human plasma by heparin affinity chromatography. , 1988, Cell structure and function.

[60]  G. Thomas,et al.  Alphavbeta6 integrin in wound healing and cancer of the oral cavity. , 2006, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[61]  B. Felding-Habermann,et al.  Integrin adhesion receptors in tumor metastasis , 2004, Clinical & Experimental Metastasis.

[62]  K. Pienta,et al.  The Role of αvβ3 in Prostate Cancer Progression , 2002 .

[63]  M. Raida,et al.  The disulfide bond pattern of catrocollastatin C, a disintegrin‐like/cysteine‐rich protein isolated from Crotalus atrox venom , 2000, Protein science : a publication of the Protein Society.

[64]  Bert Broeckaert Jean-Marc Ela , 1999 .

[65]  J. Fox,et al.  cDNA sequences for four snake venom metalloproteinases: structure, classification, and their relationship to mammalian reproductive proteins. , 1994, Archives of biochemistry and biophysics.