The two-stage mechanism controlling cellular senescence and immortalization

[1]  J. Shay,et al.  Telomere positional effects and the regulation of cellular senescence. , 1992, Trends in genetics : TIG.

[2]  J. Shay,et al.  A role for both RB and p53 in the regulation of human cellular senescence. , 1991, Experimental cell research.

[3]  E. Hara,et al.  Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. , 1991, Biochemical and biophysical research communications.

[4]  J. Shay,et al.  Defining the molecular mechanisms of human cell immortalization. , 1991, Biochimica et biophysica acta.

[5]  Barbara L. Billington,et al.  Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription , 1990, Cell.

[6]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[7]  J. Shay,et al.  Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. , 1989, Experimental cell research.

[8]  J. Shay,et al.  Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts , 1989, Molecular and cellular biology.

[9]  J. R. Smith,et al.  Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential , 1987, Molecular and cellular biology.

[10]  G. Stein.  SV40‐transformed human fibroblasts: Evidence for cellular aging in precrisis cells , 1985, Journal of cellular physiology.

[11]  T. Ide,et al.  Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40. , 1984, Experimental cell research.

[12]  J. R. Smith,et al.  Evidence for the recessive nature of cellular immortality. , 1983, Science.

[13]  J. R. Smith,et al.  Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. , 1980, Science.

[14]  A M Olovnikov,et al.  A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. , 1973, Journal of theoretical biology.

[15]  J. Weber,et al.  Transformation of human cells by temperature-sensitive mutants of simian virus-40. , 1978, Intervirology.