Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants.

Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for > or = 1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement.

[1]  Trai-Ming Yeh,et al.  Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. , 2006, The American journal of tropical medicine and hygiene.

[2]  J. Farrar,et al.  Assessment of the factors associated with flavivirus seroprevalence in a population in Southern Vietnam , 2002, Epidemiology and Infection.

[3]  S. Halstead,et al.  Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. , 1984, American journal of epidemiology.

[4]  Duane J. Gubler,et al.  Dengue and Dengue Hemorrhagic Fever , 1998, Clinical Microbiology Reviews.

[5]  N. J. Ehrenkranz,et al.  Placental passage of antibodies to Dengue virus in persons living in a region of hyperendemic Dengue virus infection. , 1975, The Journal of infectious diseases.

[6]  J. Farrar,et al.  Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. , 2007, The Journal of infectious diseases.

[7]  Cameron P. Simmons,et al.  Diagnostic Accuracy of NS1 ELISA and Lateral Flow Rapid Tests for Dengue Sensitivity, Specificity and Relationship to Viraemia and Antibody Responses , 2009, PLoS neglected tropical diseases.

[8]  J. Farrar,et al.  Dengue in Vietnamese infants--results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity. , 2008, The Journal of infectious diseases.

[9]  M. Aye,et al.  Risk factors in dengue shock syndrome. , 1997, The American journal of tropical medicine and hygiene.

[10]  A. Nisalak,et al.  Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study , 2007, The Lancet.

[11]  S. Halstead,et al.  Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. , 2009, The American journal of tropical medicine and hygiene.

[12]  S. Halstead,et al.  Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored , 2002, Emerging infectious diseases.

[13]  C. Siegrist,et al.  B-cell responses to vaccination at the extremes of age , 2009, Nature Reviews Immunology.

[14]  J. Lang,et al.  Dengue virus infections in the first 2 years of life and the kinetics of transplacentally transferred dengue neutralizing antibodies in thai children. , 2006, The Journal of infectious diseases.

[15]  A. Nisalak,et al.  Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. , 1988, The American journal of tropical medicine and hygiene.

[16]  S. Halstead,et al.  A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995-1996. , 1999, The American journal of tropical medicine and hygiene.

[17]  A. Nisalak,et al.  Transplacentally transferred maternal-infant antibodies to dengue virus. , 2003, The American journal of tropical medicine and hygiene.

[18]  A. Nisalak,et al.  A prospective study of dengue infections in Bangkok. , 1988, The American journal of tropical medicine and hygiene.

[19]  J. Groen,et al.  Seroprevalence of dengue antibodies, annual incidence and risk factors among children in southern Vietnam , 2005, Tropical medicine & international health : TM & IH.